Association between Chronic Kidney Disease and Carotid Intima-Media Thickening in Individuals with Hypertension and Impaired Glucose Metabolism

Ishizaka, Nobukazu; Ishizaka, Yuko; Toda, Etsuko; Koike, Kazuhiko; Seki, George; Nagai, Ryozo; Yamakado, Minoru

doi:10.1291/hypres.30.1035

Cited by 35 publications

(23 citation statements)

References 24 publications

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“…Our data also demonstrated that circulating omentin levels correlated inversely with creatinine levels, and positively with eGFR. Because glucose intolerance and renal dysfunction are shown to strongly associate with increased IMT, 15,16 it is reasonable that these disease conditions could affect circulating omentin levels. However, the present study suggests that omentin levels are predictive of carotid IMT, independent of glucose levels and renal function.…”

Section: Discussionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

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Section: Discussionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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“…Thus, micro-albuminuria and renal insufficiency have been demonstrated to be associated with an increased risk for myocardial infarction or stroke 6,7) . A comparable independent relation to carotid intima media thickness was described 8) ; however, the relation of the variability of renal function…”

mentioning

confidence: 59%

“…In that study, the significant correlation between IMT and MDRD was also explained by the interaction with age 18) . In contrast, Ishizaka et al found an association between more severe CKD (individuals with either a low eGFR or albuminuria or both) and IMT 8) . In this group, MDRD was independently associated with IMT after adjustment for age, showing that this relation appears to exist in more severe cases of renal dysfunction.…”

Section: Resultsmentioning

confidence: 86%

Relation between Physiological Variation of Renal Function and Carotid Intima Media Thickness in Non-Diabetic Individuals

Bobbert

Mai

Fischer-Rosinský

et al. 2010

JAT

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Aim: Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, the association between renal function and intima media thickness (IMT) in non-diabetic individuals is less clear. We therefore investigated the relation between renal function, established cardiovascular risk factors and carotid intima media thickness in non-diabetic individuals.

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“…Polymorphisms examined in the present study (Table I) were selected from genome-wide association studies of ischemic stroke (14) and myocardial infarction. Given that atherosclerosis is an important risk factor for CKD (15), genetic variants related to atherosclerotic disease such as ischemic stroke and myocardial infarction might also contribute to the development of CKD. We have not examined the relation of these polymorphisms in the previous studies (7,8,(16)(17)(18)(19).…”

Section: Selection Of Polymorphismsmentioning

confidence: 99%

Association of gene polymorphisms with chronic kidney disease in Japanese individuals

Yamada¹

2009

Int J Mol Med

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Abstract. Chronic kidney disease (CKD) is recognized as a risk factor not only for end-stage renal disease but also for cardiovascular disease. Early detection and treatment of CKD is a likely key factor for prevention of its complications. Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to CKD, the genes that underlie genetic susceptibility to this condition have remained largely unknown. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals. The study population comprised 4,829 Japanese individuals (2,697 men, 2,132 women), including 757 subjects with CKD [464 men, 293 women; estimated glomerular filtration rate (eGFR) <50 ml min 1.73 m -2 ] and 4,072 controls (2,233 men, 1,839 women; eGFR ≥60 ml min 1.73 m -2 ). The genotypes for 40 polymorphisms of 39 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of CKD. Among these polymorphisms, the C→T polymorphism of F10 (rs5962) was most significantly associated with this condition. Determination of genotypes for the C→T polymorphism of F10 may prove informative for assessment of genetic risk for CKD in Japanese individuals.

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Association between Chronic Kidney Disease and Carotid Intima-Media Thickening in Individuals with Hypertension and Impaired Glucose Metabolism

Abstract: We investigated whether chronic kidney disease (CKD) was associated with carotid intima-media thickening

Cited by 35 publications

References 24 publications

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Relation between Physiological Variation of Renal Function and Carotid Intima Media Thickness in Non-Diabetic Individuals

Association of gene polymorphisms with chronic kidney disease in Japanese individuals

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