Association between chronic stress and immune response to influenza vaccine in healthcare workers

Sacadura‐Leite, Ema; Uva, António de Sousa; Rebelo-de-Andrade, Helena; Ferreira, Sancha; Rocha, Regina

doi:10.1016/j.rpsp.2013.09.002

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…As expected, a high degree of anxiety, stress, and burnout was reported during the COVID-19 pandemic [23], and Sacadura-Leite et al reported a reduction in humoral immune response post-vaccine in healthcare personnel, explained mostly by the chronic stress and burnout. The paper reports a significant relationship between a reduction in hemagglutination-inhibition (HAI) antibodies six months after flu vaccine and chronic stress in HWs [24]. There is a close relationship between stress and the neuroendocrine system throughout the hypothalamic-pituitary-adrenal (HPA) axis, one of the major stresssignaling pathways [25].…”

Section: Health Problems Of Civilizationmentioning

confidence: 99%

ANTIBODY RESPONSE AFTER SARS-CoV-2 mRNA VACCINE IN NAÏVE AND PREVIOUSLY INFECTED HEALTHCARE WORKERS

Huţanu¹,

Dobreanu²

2022

hpc

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Authors' contributionWkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane -analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy SummaryBackground. Evaluating and monitoring plasma levels of anti-SARS-CoV-2 antibodies in healthcare workers, together with the vaccination of this at-risk population is important for maintaining the viability of the healthcare system, especially during the emergence of new viral variants. The aim of this study is to investigate plasma levels of anti-SARS-CoV-2 antibodies in healthcare providers following full vaccination, in both naïve and previously infected individuals. Material and methods. Complete data were available for 89 healthcare workers from the larger group of 102 initial participants. Plasma was collected at least one month, and no later than two months after the full dose of an mRNA vaccine, and analyzed by determining the total antibody concentration against the spike protein using an ECLIA kit. Results. The degree of humoral-specific immune response was at least 5-fold higher in previously infected healthcare workers compared to naïve persons that received the vaccine only. The highest titer was found in office-based staff, relative to those found in doctors and nurses. However, this difference lacks statistical significance. Among previously infected participants, nurses had significantly higher antibody titers, when compared to doctors. Conclusions. The study revealed a sustained immune response after mRNA vaccine among healthcare workers, with enhanced response in previously infected subjects, highlighting a boosting effect of the vaccine.

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Section: Health Problems Of Civilizationmentioning

confidence: 99%

ANTIBODY RESPONSE AFTER SARS-CoV-2 mRNA VACCINE IN NAÏVE AND PREVIOUSLY INFECTED HEALTHCARE WORKERS

Huţanu¹,

Dobreanu²

2022

hpc

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“…Interventional medicine uses fluoroscopic equipment to allow internal body visualization and to guide medical personnel during invasive procedures. That equipment is used in different kinds of procedures that include some surgeries (Sacadura-Leite et al, 2006) or interventional medical procedures (such as cardiologic, nephrologic and gastroenterologic intervention techniques) and staff is exposed, mostly to scatter radiation (Rehani & Ortiz-Lopez, 2006).…”

Section: Physical and Ergonomic Related Hazardsmentioning

confidence: 99%

International Symposium on Occupational Safety and Hygiene: Proceedings Book of the SHO2015

2015

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A Sociedade Portuguesa de Segurança e Higiene Ocupacionais realiza, em 12 e 13 de Fevereiro de 2015, a 11ª edição do Colóquio Internacional de Segurança e Higiene Ocupacionais - SHO 2015. Tal como nos 9 últimos anos, o evento tem lugar no Auditório Nobre da Escola de Engenharia da Universidade do Minho, em Guimarães. A edição de 2015 abrange as temáticas da Ergonomia e do Ambiente Físico, dos Riscos Químicos e Biológicos, da Segurança contra Incêndio e da Gestão da Prevenção, que são objecto de sessões plenárias, decorrendo ainda várias sessões paralelas de comunicações livres nas mais de 25 áreas temáticas previstas para o evento, bem como várias sessões com apresentação de posters.

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Nursing Burnout and Its Impact on Health

Sullivan

Hughes

Wilson

2022

Nursing Clinics of North America

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Association between chronic stress and immune response to influenza vaccine in healthcare workers

Cited by 5 publications

References 23 publications

ANTIBODY RESPONSE AFTER SARS-CoV-2 mRNA VACCINE IN NAÏVE AND PREVIOUSLY INFECTED HEALTHCARE WORKERS

ANTIBODY RESPONSE AFTER SARS-CoV-2 mRNA VACCINE IN NAÏVE AND PREVIOUSLY INFECTED HEALTHCARE WORKERS

International Symposium on Occupational Safety and Hygiene: Proceedings Book of the SHO2015

Nursing Burnout and Its Impact on Health

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