Association Between Circulating Lymphocyte Populations and Outcome After Stereotactic Body Radiation Therapy in Patients With Hepatocellular Carcinoma

Zhuang, Yuan; Yuan, Binhang; Chen, Gen-wen; Zhao, Xiaomei; Hu, Yong; Zhu, Wenchao; Zeng, Zhao‐Chong; Chen, Yixing

doi:10.3389/fonc.2019.00896

Cited by 28 publications

(31 citation statements)

References 44 publications

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“…Emerging evidence showing radiation-induced lymphopenia (RIL) or PLC-related parameters are associated with poor survival outcomes in several solid tumors (9)(10)(11)(12)(13)(14). Cho et al reported RIL was a potential predictor for ipsilateral breast tumor recurrence in 216 patients with early breast cancer treated with breast-conserving therapy (BCT) (15).…”

Section: Introductionmentioning

confidence: 99%

Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy

Chen

Zhang

et al. 2021

Ann Transl Med

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Background: This study aimed to investigate radiation-induced lymphopenia and its potential risk factors in patients with breast cancer receiving adjuvant radiotherapy.Methods: Breast cancer patients received adjuvant radiotherapy (RT) at our hospital with peripheral lymphocyte counts (PLC) at pre-and immediately after RT (post-RT) were eligible. The primary endpoints were any grade of lymphopenia post-RT and nadir-PLC/pre-PLC <0.8. Patient characteristics, tumor factors, and treatment factors were collected for risk assessment. Data are presented as mean and 95% confidence interval (CI) unless otherwise specified. Matched analysis was used to compare the statistical significance between different RT techniques.Results: A total of 735 consecutive patients met the study criteria. The mean PLC was 1.58×10 9 /L before and 0.99×10 9 /L post-RT (P<0.001). At the end of RT, 60.5% of patients had lymphopenia. Univariate and multivariable logistic analyses showed that RT technique involving RapidArc, mean lung dose, and chemotherapy were significant risk factors (P<0.05) for lymphopenia. RT technique was the only significant risk factor (P<0.05) for nadir-PLC/pre-PLC <0.8. Patients treated with RapidArc had a significantly greater reduction of PLC along with greater V5 of the lungs, even after matching mean lung dose and radiated volume.Conclusions: Lymphopenia is common in patients with breast cancer after adjuvant RT. RT technique is the only significant factor for lymphopenia and nadir-PLC/pre-PLC <0.8, suggesting the significance of RT technique choice to minimize lymphopenia and improve treatment outcomes.

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Section: Introductionmentioning

confidence: 99%

Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy

Chen

Zhang

et al. 2021

Ann Transl Med

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“…At present, the impact of the follow-up period on circulating lymphocyte subsets following liver transplantation is unclear. Zhuang et al detected that the cell counts of T, TCD4, TCD8, B, and NK dropped profoundly shortly after stereotactic body radiation therapy and gradually recovered 2 months later ( 37 ). Similarly, we observed that the absolute numbers of lymphocyte subsets were reduced in LTR with short-term follow-up.…”

Section: Discussionmentioning

confidence: 99%

The Model for End-Stage Liver Disease Score and the Follow-Up Period Can Cause the Shift of Circulating Lymphocyte Subsets in Liver Transplant Recipients

Fang

Cao

et al. 2022

Front. Med.

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Little is known about the shift of lymphocytes under the condition of the model for end-stage liver disease score and the follow-up period. Then, we detected the peripheral blood from liver transplant recipients by flow cytometry and compared the results. The model for end-stage liver disease score affected the percentages of T-cell subsets and B cells during the short-term follow-up period, but failed to influence the lymphocyte subsets during the long-term follow-up period. In contrast, the follow-up period not only affected the absolute counts of T-cell subsets and natural killer (NK) cells in patients with the low model for end-stage liver disease scores, but also influenced the percentages and absolute counts of T-cell subsets in patients with the high model for end-stage liver disease scores. In the two-way ANOVA, we further revealed that the model for end-stage liver disease score was associated with the percentages of T cells and CD4+ T cells and the absolute numbers of T-cell subsets and B cells, while the follow-up period was associated with the percentages of T-cell subsets and the absolute numbers of lymphocyte subsets. Therefore, patients with either the low model for end-stage liver disease scores or the long-term follow-up period are in a relatively activated immune condition.

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“…Moreover, RT kills not only TILs but also peripheral blood lymphocytes passing through the irradiation field and may induce lymphopenia. Of note, there are emerging data revealing that severe lymphopenia is associated with a poor prognosis in patients with different tumors (53)(54)(55). Therefore, the size of the radiation field should be reasonably limited when investigating combination therapy (7).…”

Section: Discussionmentioning

confidence: 99%

Intracranial radiotherapy with or without immune checkpoint inhibition for brain metastases: a systematic review and meta-analysis

He¹,

Zhang²,

Tang³

et al. 2020

Transl Cancer Res TCR

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Background: With the development of immunotherapy in recent years, the prognosis of patients is expected to improve due to immune checkpoint inhibition (ICI) combined with radiotherapy (RT). However, studies on combination therapy (ICI + intracranial RT) have reported inconsistent results, and it is unclear whether the combination has increased toxicity. By analyzing the latest relevant literature, we performed a meta-analysis to further clarify the effectiveness and safety of intracranial RT combined with ICI in patients with brain metastases (BMs).Methods: We searched PubMed, Embase and the Cochrane Library for published studies that compared the efficacy and safety of intracranial RT combined with ICI versus intracranial RT alone in the treatment of BMs. Overall survival (OS), local brain failure (LBF), distant brain failure (DBF), and radiation necrosis (RN) were pooled with the use of the hazard ratio (HR) or odds ratio (OR).Results: A total of 26 retrospective observation cohort studies were included, and over 1,500 patients who received ICI and intracranial RT were evaluated. Compared with intracranial RT alone, RT combined with ICI significantly improved OS in patients with BMs [HR =0.55, 95% confidence interval (CI): 0.48-0.64, P<0.001 when OS was defined from the date of diagnosis of BMs; HR =0.45, 95% CI: 0.39-0.52, P<0.001 when OS was defined from the date of RT], though the risk of RN was similar to that of RT alone (HR

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Association Between Circulating Lymphocyte Populations and Outcome After Stereotactic Body Radiation Therapy in Patients With Hepatocellular Carcinoma

Cited by 28 publications

References 44 publications

Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy

Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy

The Model for End-Stage Liver Disease Score and the Follow-Up Period Can Cause the Shift of Circulating Lymphocyte Subsets in Liver Transplant Recipients

Intracranial radiotherapy with or without immune checkpoint inhibition for brain metastases: a systematic review and meta-analysis

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