Association between clinical features, treatment, and recurrence rate of adenoid cystic carcinoma of the palate: a 10-year retrospective study

Aliabadi, Ehsan; Maleki, Mohammad Javad; Barouj, Mehrdad Dehghanpour

doi:10.1016/j.bjoms.2016.03.023

Cited by 2 publications

(8 citation statements)

References 23 publications

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“…The palate, especially the hard palate, is the most frequent site of salivary gland ACC. 3 In this study, the tumor was located in the hard palate or junction of the hard and soft palate in >80% of patients. In general, palate tumors are slow growing and without obvious symptoms.…”

Section: Discussionmentioning

confidence: 66%

“…Thus, local failure in this area is high likely. 3 In this study, 8 out of the 21 patients who underwent LR experienced a recurrence in the upper boundary, including the base of the skull, floor of the orbit, and even the middle fossa of the skull, resulting in a loss of opportunities for reoperation. Therefore, great attention should be paid to resection of the upper part of the tumor during surgery.…”

Section: Discussionmentioning

confidence: 87%

“…11 Consistent with previous studies, positive margins were found to be an independent predictor of low LRFS and OS in this study. 3 In both univariate and multivariate analyses, positive margins were significantly associated with lower OS and LRFS. Furthermore, high histopathological grade is an independent predictor of poor overall survival.…”

Section: Discussionmentioning

confidence: 94%

“…The positive margin rate in this study (35.3%) was close to that in previous reports (38.6%-54.4%) on ACC of the head and neck. 11,21,22 Tabrizi et al 3 showed that, in ACC of the palate, close surgical margins-especially superior and posterior margins-influence local recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

“…Achieving negative margins can be challenging due to the growth characteristics of ACC and the complex anatomy of the palatal region. 3 Because evaluation of the resection margin of head and neck tumors is selective and ACC have a unique growth and invasion pattern, even if the margins are reported as negative, it does not mean that the tumor is completely removed. The National Comprehensive Cancer Network guidelines recommend the combination of surgery and radiotherapy to improve the local control rate in patients with ACC.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors of palatal adenoid cystic carcinoma: A single‐center analysis of 85 cases

Gu,

Chi,

et al. 2024

Laryngoscope Investig Oto

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ObjectiveThe purpose of this retrospective study was to describe the clinicopathological characteristics of primary adenoid cystic carcinoma (ACC) of the palate and to identify the factors affecting prognosis.MethodsThe medical records of 85 patients with primary ACC of the palate treated with surgery, with or without adjuvant radiotherapy/chemotherapy, from 2009 to 2019 were reviewed. The relationship of different clinical parameters with locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) were analyzed.ResultsMedian follow‐up time was 44.6 months. LR and DM rates were 24.7% and 25.9%, respectively, and the 5‐year OS and disease‐free survival (DFS) rates were 85.9% and 55.1%, respectively. Multivariate analysis showed that positive margins were independently associated with the risk of LR (p < .001). Positive margins (p = .001) and high histological grade (p = .031) were significantly associated with shorter OS.ConclusionPositive surgical margins are a strong adverse prognostic factor affecting LR and OS in patients with ACC; apart from that, high histopathological grade is an independent predictor of poor OS.Level of EvidenceLevel 3 (Prognosis – Cohort study).

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic factors of palatal adenoid cystic carcinoma: A single‐center analysis of 85 cases

Gu,

Chi,

et al. 2024

Laryngoscope Investig Oto

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Computed tomographic features of adenoid cystic carcinoma in the palate

Zhao

Liu

et al. 2019

Cancer Imaging

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BackgroundTo evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.MethodsFrom March 2016 to May 2018, 102 patients with palatal tumors and intact mucosa, including 28 patients with a pathological diagnosis of ACC after surgery, were enrolled in this study. The patients’ clinical symptoms, computed tomographic features and pathological diagnoses were recorded and analyzed. Independent predictors of ACC were determined by using univariate analysis and multivariate logistic regression, and the discrimination and calibration of the prediction model was evaluated, and internal validation was performed.ResultsUnivariate analysis of patients showed that ACC patients were more likely than non-ACC patients to be older (P = 0.019); to have palatine bone destruction (P<0.001) and greater palatine foramen (GPF) enlargement (P<0.001); to have involvement of the pterygopalatine fossa (P<0.001), foramen rotundum (P<0.001), nasal cavity (P<0.001) and maxillary bone (P<0.001); and to have numbness (P = 0.007) and pain (P<0.001). Multivariate logistic analysis showed that age and GPF enlargement were independent predictors of ACC in palatal tumors. The diagnostic prediction model showed good discrimination and calibration, as evaluated by the area under the receiver operating characteristic curve (0.98) and the Hosmer-Lemeshow goodness-of-fit test (P = 0.927).ConclusionsThe palate ACC prediction model based on age and GPF enlargement shows excellent discrimination with no evidence of poor calibration. Older patients with palatal tumors and intact mucosa should be considered for ACC when they have GPF enlargement.Electronic supplementary materialThe online version of this article (10.1186/s40644-019-0190-z) contains supplementary material, which is available to authorized users.

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Association between clinical features, treatment, and recurrence rate of adenoid cystic carcinoma of the palate: a 10-year retrospective study

Cited by 2 publications

References 23 publications

Prognostic factors of palatal adenoid cystic carcinoma: A single‐center analysis of 85 cases

Prognostic factors of palatal adenoid cystic carcinoma: A single‐center analysis of 85 cases

Computed tomographic features of adenoid cystic carcinoma in the palate

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