Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Bastiani, Rudi De; Gabrielli, Maurizio; Lora, L.; Napoli, Luigi De; Tosetti, Cesare; Pirrotta, Enzo; Ubaldi, Enzo; Bertolusso, L.; Zamparella, Maria; Polo, Manuela De; Nebiacolombo, C; Bortot, Mario; Mancuso, Maurizio; Bacchin, Paolo; Marsala, Valerio; Pinna, Roberto; Tursi, Antonio; Benedetto, Edoardo; Cuffari, Alfredo; Pati, Antonino; Di, Simona; Perenzin, G; Sala, Raffaella; Pinton, Giacomo Calzavara; Gasbarrini, Antonio

doi:10.1159/000369615

Cited by 56 publications

(62 citation statements)

References 23 publications

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“…We focused on anti-gliadin and anti-endomysial antibodies, but they were absent in both patients and control group. Research concerning Italian [24] and Kashmir population [25] suggests that there may be some genetic differences between populations as in these studies no correlations between AGA and the prevalence of psoriasis were found.…”

Section: Discussionmentioning

confidence: 68%

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Lesiak¹,

Bednarski²,

Pałczyńska³

et al. 2016

pdia

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IntroductionPustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. There is also evidence that anti-endomysial (anti-EMA) and anti-gliadin (AGA) antibodies are engaged in PPP development.AimTo assess IL-15, IL-17, IL-22 serum levels and evaluate the presence of anti-endomysial and anti-gliadin antibodies in patients with PPP.Material and methodsThe study group consisted of 20 females of the mean age of 51.8 suffering from PPP. Additionally 29 healthy individuals, age and sex matched, served as controls. ELISA was performed to evaluate serum IL-15, IL-17, IL-22 concentrations while an indirect immunofluorescence test (IIF) was used to determine anti-EMA and AGA presence.ResultsThe mean value of IL-15 and IL-22 serum concentrations was significantly higher in the study group than in the control group (IL-15: 6.48 vs. 4.88 pg/ml; IL-22: 81.47 vs. 4.90 pg/ml, respectively; p < 0.05 for all comparisons). The IL-17 serum level in the study group was higher when compared to the control group (2.0 vs. 0.75 pg/ml), however the results were not statistically significant (p = 0.26). There were no anti-EMA and AGA antibodies detected, both in the control and study group.ConclusionsThe results obtained may suggest involvement of IL-15 and IL-22 in the pathogenesis of PPP.

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Section: Discussionmentioning

confidence: 68%

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Lesiak¹,

Bednarski²,

Pałczyńska³

et al. 2016

pdia

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“…Several studies have documented celiac disease and psoriasis coexistence and the improvement of psoriatic lesions after starting a GFD [11, 12, 50]. The benefit of GFD has been shown to extend to patients who are antigliadin antibody-positive but without clinical and histological markers of celiac disease [13–15].…”

Section: Discussionmentioning

confidence: 99%

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Afifi

Danesh

Lee

et al. 2017

Dermatol Ther (Heidelb)

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IntroductionPsoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis patients and associated outcomes. This study aims to identify common dietary habits, interventions and perceptions among patients with psoriasis, and to examine patient-reported skin outcomes in response to these interventions.MethodsWe administered a 61-question survey to the National Psoriasis Foundation membership asking psoriasis patients about dietary habits, modifications, skin responses, and perceptions.ResultsA total of 1206 psoriasis patients responded to the survey. Compared to age- and sex-matched controls, psoriasis patients consumed significantly less sugar, whole grain fiber, dairy, and calcium (p < 0.001), while consuming more fruits, vegetables, and legumes (p < 0.01). Eighty-six percent of respondents reported use of a dietary modification. The percentage of patients reporting skin improvement was greatest after reducing alcohol (53.8%), gluten (53.4%), nightshades (52.1%), and after adding fish oil/omega-3 (44.6%), vegetables (42.5%), and oral vitamin D (41%). Specific diets with the most patients reporting a favorable skin response were Pagano (72.2%), vegan (70%), and Paleolithic (68.9%). Additionally, 41.8% of psoriasis respondents reported that a motivation for attempting dietary changes was to improve overall health.ConclusionThis national survey is among the first to report the dietary behaviors of patients with psoriasis. The data provided from this large cohort may benefit patients and clinicians as they discuss the role of diet in managing both psoriasis and associated cardiometabolic comorbidities.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-017-0183-4) contains supplementary material, which is available to authorized users.

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“…Based on the positive anti-transglutaminase antibodies which are a highly sensitive and specific marker of coeliac disease, we can confirm the association between coeliac disease and psoriasis. In other words, this result shows a higher prevalence of coeliac disease in patients with psoriasis than in the general population 1,2,4 . For this reason, dermatologists and general practitioners are advised to ask their psoriatic patients questions concerning bowel problems, and to perform tests for coeliac disease via thorough examination 2 .…”

Section: Discussionmentioning

confidence: 64%

“…An early diagnosis and adherence to a gluten-free diet for 3-6 months leads to an improvement of skin psoriatic lesions without any pharmacological treatment 3,4 and thus significantly improves the quality of life of these patients. The effect of a gluten-free diet on psoriatic lesions has not been clearly explained.…”

Section: Discussionmentioning

confidence: 99%

“…The results of some recent studies show an increased occurrence of psoriasis in patients with coeliac disease 1,2 . The association between coeliac disease and psoriasis is strongly suggested as a gluten-free diet leads to a clear improvement and disappearance of psoriatic skin lesions in some patients 3,4 . According to Aggarwal et al, the screening of coeliac disease in asymptomatic individuals suffering from an autoimmune disease is recommended 5 .…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Jůzlová¹,

Votrubová²,

Džambová³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. Methods. This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases. Results. There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis. Conclusion. Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.

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Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Cited by 56 publications

References 23 publications

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

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