Rhinology disorders, including sinusitis, rhinitis, allergic diseases, and structural problems, often go unnoticed and undertreated. Yet, these seemingly localized issues can have far-reaching effects. Over time, problems in the rhino-sinus and upper airway systems can impact the nervous system, social interactions, and psychological well-being. Patients may experience anxiety, depression, and difficulties with learning, memory, and social behavior. These hidden complications are crucial for healthcare professionals to recognize, as addressing them can significantly improve patients’ quality of life. This chapter will delve deeper into the intricate relationship between rhinology disorders and psychological impacts, exploring the possible underlying mechanisms. It will offer insights into effective management and treatment strategies, aiming to empower healthcare professionals to provide holistic care that encompasses the physical, psychological, and social aspects of their patients’ lives.