Association between cognitive impairment and criteria for frailty syndrome among older adults

Brígola, Allan Gustavo; Ottaviani, Ana Carolina; Carvalho, Danilo Henrique Trevisan de; Oliveira, Nathalia Alves de; Souza, Érica Nestor; Pavarini, Sofía Cristina Iost

doi:10.1590/0004-282x20190138

Cited by 28 publications

(24 citation statements)

References 43 publications

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“…Our findings extend the literature by describing different patterns of association of MBI and its components with frailty, a pattern not previously established. Prior studies exploring the link between frailty and cognition have focused on individual functional abilities and assessed only global cognitive ability or limited cognitive domains [14,75]. The mechanisms for the association are not clear, but possibly involve abnormalities in biological processes related to aging [76].…”

Section: Discussionmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

et al. 2020

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Background Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a dementia risk syndrome characterized by later-life emergence of persistent neuropsychiatric symptoms, has yet to be elucidated. We aimed to evaluate the associations between MBI and frailty in older adults without dementia. Methods In this cross-sectional study, a consecutive series of 137 older adults without dementia in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist (MBI-C) at a cut-off point of > 8. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariable logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status. Results At baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariable logistic regression analysis demonstrated that compared to those without MBI (MBI- status), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49–37.21, p = 0.02). Frailty and MBI were both significantly associated with both MMSE and MoCA-BC score (p < 0.05). Conclusions Both frailty and MBI status were associated with higher odds of cognitive impairment. MBI was significantly associated with an increased risk of having frailty in the absence of dementia. This association merits further study to identify potential strategies for the early detection, prevention and therapeutic intervention of frailty.

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Section: Discussionmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

et al. 2020

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“…Our ndings extend the literature by describing different patterns of association of MBI and its components with frailty, a pattern not previously established. Prior studies exploring the link between frailty and cognition have focused on individual functional abilities and assessed only global cognitive ability or limited cognitive domains (14,77). The mechanisms for the association are not clear, but possibly involve abnormalities in biological processes related to aging (78).…”

Section: Discussionmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Fan

Liang

Yun

et al. 2020

Preprint

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Background: Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a dementia risk syndrome characterized by later-life emergence of persistent neuropsychiatric symptoms, has yet to be elucidated. We aimed to evaluate the associations between MBI and frailty in older adults without dementia.Methods: In this cross-sectional study, a consecutive series of 137 older adults without dementia in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist (MBI-C) at a cut-off point of >8. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariable logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status.Results: At baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariable logistic regression analysis demonstrated that compared to those without MBI (MBI- status), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49-37.21, p = 0.02). Frailty and MBI were both significantly associated with both MMSE and MoCA-BC score (p<0.05).Conclusions: Both frailty and MBI status were associated with higher odds of cognitive impairment. MBI was significantly associated with an increased risk of having frailty in the absence of dementia. This association merits further study to identify potential strategies for the early detection, prevention and therapeutic intervention of frailty.

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“…Our ndings extend the literature by describing different patterns of association of MBI and its components with frailty, a pattern not previously established. Prior studies of the link between frailty and cognition have focused on individual functional abilities and assessed only global cognitive ability or limited cognitive domains (14,68). The mechanisms for the association are not clear, but possibly involves abnormalities in biological processes related to aging (69).…”

Section: Discussionmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Fan

Liang

Yun

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a neurobehavioral syndrome characterized by later-life emergence of sustained neuropsychiatric symptoms, has yet to be elucidated.We aimed to evaluate the associations between mild behavioral impairment and frailty in non-dementia older adults.Methods: This is a cross-sectional study. A consecutive series of 137 non-dementia older adults in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist at a cut-off point of >8 (optimizing sensitivity and specificity), which was developed to assess emergent neuropsychiatric symptoms in accordance with the MBI criteria. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariate logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status.Results: At baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariate logistic regression analysis demonstrated that compared to MBI- status (without MBI), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49-37.21, p = 0.02).Conclusions: MBI is significantly associated with an increased risk of having frailty before the presence of overt dementia. This association merits further study to identify strategies for the early detection, prevention and therapeutic intervention of frailty.

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Association between cognitive impairment and criteria for frailty syndrome among older adults

Cited by 28 publications

References 43 publications

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

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