Association between colon diverticula and hemoglobin, triglyceride and uric acid levels

Abstract

Abstract. Colon diverticula cause bleeding and acute diverticulitis. The present study analyzed laboratory test variables, aiming to predict the presence of diverticula. Patient records from between April 2011 and March 2014 were analyzed retrospectively (1,520 patients) and a one-way analysis of variance was performed to analyze the association between the presence of diverticula and each variable. A χ 2 test was then used to assess the correlation between the prevalence of diverticula and the percentage of patients with uric acid (UA) levels ≥5.1 mg/dl. A receiver operating characteristic (ROC) analysis was performed to determine the threshold values required to predict the presence of diverticula. Hemoglobin (Hb) levels were lower in patients with diverticula than in those without diverticula (P=0.0027), and compared with patients without diverticula, UA and triglyceride (TG) levels were higher in patients with diverticula (P=0.0066 and P=0.0136, respectively). The patients were divided into two groups, as follows: Patients with UA levels ≥5.1 mg/dl (the median value) and those with UA levels <5.1 mg/dl. The prevalence of diverticula was significantly higher in patients with UA levels ≥5.1 mg/dl than in those with UA levels <5.1 mg/dl (P=0.0004). ROC analysis demonstrated that the threshold values of Hb, TG and UA were 12,400, 146 and 5.1 mg/dl, respectively. The sensitivity of the Hb and UA levels at the threshold values was 76.5 and 71.0%, respectively. The prevalence of diverticula was associated with low Hb levels, and high TG and UA levels.

Association between serum uric acid levels and colonic diverticulosis in terms of sex

“…Previous studies have shown that factors such as increasing age [ 6 ], male sex [ 7 ], and alcohol consumption [ 5 ] are correlated with colonic diverticulosis. Intense physical activity decreases the risk of colonic diverticulitis and colonic diverticular hemorrhage [ 21 , 22 ].…”

“…Data from other studies revealed a correlation between serum UA levels, CVD, CKD, and stroke [ 26 ]. However, few studies [ 7 ] have assessed the association between serum UA levels and colonic diverticulosis. Several studies have shown that patients with hyperuricemia are at a higher risk of developing colonic diverticular hemorrhage [ 27 ].…”

“…To the best of our knowledge, this research first showed a sex-specific association. A high UA level was found to be associated with a high prevalence of diverticulosis [ 7 ]. We calculated the AUCs according to sex (0.651 [95% CI: 0.596–0.707] in women and 0.55 [95% CI: 0.507–0.593] in men).…”

“…The etiopathogenesis of colonic diverticulosis and diverticular disease is not well understood [ 5 ]. The risk factors for colonic diverticulosis include increasing age, [ 6 ] male sex, [ 7 ] and physical inactivity. Some studies have revealed that excessive alcohol consumption [ 5 ] may be a risk factor for the different types of diverticulosis.…”