Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea

Uygur, Fırat; Tanrıverdi, Hakan; Çan, Murat; Erboy, Fatma; Altınsoy, Bülent; Atalay, Figen; Örnek, Tacettin; Damar, Murat; Köktürk, Fürüzan; Tor, Meltem

doi:10.1007/s11325-016-1315-2

Cited by 11 publications

(13 citation statements)

References 21 publications

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“…It also demonstrated that a low omentin level could be regarded as a specific diagnostic marker for the occurrence and deterioration of OSAS [ 61 ]. Uygur et al [ 106 ] reported that the lower serum omentin level in OSAS can be reversed by CPAP treatment, which also confirmed the previous observations. More investigations are required to understand the exact roles and mechanisms of omentin in OSAS.…”

Section: Roles Of Omentin In Pulmonary Diseasesupporting

confidence: 77%

“…Importantly, omentin increased endothelial NO expression, mitigated inflammation, and oxidation in human endothelial cells [ 70 , 71 ]. However, studies for determining omentin levels in OSAS patients have yielded contradictory results [ 61 , 62 , 63 , 106 ]. Two studies reported that omentin levels increased in patients with OSAS [ 62 , 63 ], whereas the levels of omentin in plasma were reduced to normal values after continuous positive airway pressure (CPAP) therapy for three months, [ 63 ]; unfortunately, the sample sizes used in these studies were small.…”

Section: Roles Of Omentin In Pulmonary Diseasementioning

confidence: 99%

“…A series of epidemiological studies highlighted that omentin levels were inversely correlated with obesity, T2DM, and hypertension [ 16 , 108 ]. Moreover, studies showed that omentin levels were extremely low in patients with OSAS and correlated with the severity of OSAS [ 61 , 106 ], which may ultimately induce PAH and RHF. Kazama et al [ 72 , 108 ] observed that omentin suppressed agonist-induced rise in blood pressure (BP) and monocrotaline-induced enhancement in PA pressure.…”

Section: Roles Of Omentin In Pulmonary Diseasementioning

confidence: 99%

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Omentin-A Novel Adipokine in Respiratory Diseases

Zhou

Zhang

Hao

et al. 2017

IJMS

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Adipokines, secreted by the adipose tissue, are extensively involved in the regulation and maintenance of various physiological and pathological processes, including insulin sensitivity, energy expenditure, glucose and lipid metabolism, inflammatory activity, neuroendocrine activity, immunity, cancer, homeostasis, angiogenesis, cardiovascular function, breeding and bone metabolism, and all functions of the endocrine-reproductive system axis. Omentin is a recently identified adipokine, which has become a research hotspot due to its pleiotropic effects on various diseases. However, the specific receptor for omentin has not been identified so far. In this study, we report that omentin levels fluctuate in various diseases. In addition, we have focused on the pleiotropic roles of omentin in pulmonary diseases, as it may act as a biomarker for malignant pleural mesothelioma (MPM) and is related to disease severity. Omentin may play significant roles in other pulmonary diseases, such as asthma, obstructive sleep apnea syndrome (OSAS), pulmonary arterial hypertension (PAH), acute respiratory distress syndrome (ARDS), and chronic obstructive pulmonary disease (COPD). This review summarizes the advances in current knowledge and future trends, which may provide a concise and general view on omentin and its effects on pulmonary biology.

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Section: Roles Of Omentin In Pulmonary Diseasesupporting

confidence: 77%

Section: Roles Of Omentin In Pulmonary Diseasementioning

confidence: 99%

Section: Roles Of Omentin In Pulmonary Diseasementioning

confidence: 99%

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Omentin-A Novel Adipokine in Respiratory Diseases

Zhou

Zhang

Hao

et al. 2017

IJMS

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“…On the other hand the reduced omentin levels are related with atherosclerosis, hypertension, cardiovascular disease and obstructive sleep apnea [26,28]. Omentin is inversely correlated with BMI, insulin resistance and positively with HDL and adiponectin [29].…”

Section: Discussionmentioning

confidence: 99%

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

Machura¹,

Ziora²,

Szczepańska³

et al. 2017

Pediatr. Endocrinol.

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Introduction. Patients with cystic fibrosis (CF) present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentration. The aim of the study is to evaluate serum concentration of chemerin, omentin and vaspin in children with cystic fibrosis. Material and Methods. The study group included 21 children (mean age 11.3±0.4 years) with stable CF. The diagnosis of CF was established by sweat test and later confirmed by genetic examination in all subjects. Patients with pulmonary exacerbation were excluded from study. In all children history, physicalexamination, anthropometric parameters, sputum, blood samples, and lung function tests were assessed.The control group consisted of 22 healthy children (mean age 10.9 ±4.4years). Results. The mean serum levels of chemerin and omentin were higher (p<0.001) in CF children than in healthy children. The mean serum vaspin concentration was significantly lower than in controls (p<0.001). Concentrations of examined adipokines showed no correlation with BMI, BMI-SDS, Słowa kluczowe mukowiscydoza, chemeryna, omentyna, waspina, dzieci Streszczenie Wstęp. Pacjenci z mukowiscydozą (cysticfibrosis, CF) prezentują liczne patologiczne stany, jak niedożywienie, zmniejszenie masy tłuszczowej ciała, zaburzenia metaboliczne (zaburzony metabolizm glukozy, wzrost insulinooporności, przewlekły deficyt energii, miejscowe i chroniczne zapalenie), które mogą mieć związek z zaburzeniami stężeń adipokin. Celem badań jest ocena stężenia chemeryny, omentyny i waspiny w surowicy krwi u dzieci z mukowiscydozą. Materiał i metody. Badaniami objęto21 dzieci (średni wiek: 11,7± 1,59 lat) ze stabilną CF. Diagnozę CF u tych dzieci potwierdzono badaniem genetycznym. Pacjentów z zaostrzeniem choroby wykluczono z badań. U wszystkich dzieci przeprowadzono wywiad, badanie fizykalne i antropometryczne, zbadano plwocinę, pobrano krew, wykonano czynnościowe badania płuc. Grupę kontrolną stanowiło 22 zdrowych dzieci (średni wiek: 10,9 ± 4,4 lat). Wyniki. Średnie stężenie chemeryny i omentyny w surowicy krwi było istotnie wyższe (p<0.001), a waspiny znamiennie niższe (p<0,001) u dzieci z mukowiscydozą aniżeli u zdrowych. Nie stwierdzono znamiennych statystycznie korelacji pomiędzy stężeniem badanych adipokin we krwi a BMI, BMI-SDS, glukozą, cholesterolem całkowitym, LDL i HDL we krwi. FEV1 i FVC Praca oryginalna

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“…Zhang et al also found that plasma omentin-1 levels were significantly lower in 30 overweight male patients with severe OSA compared to 20 controls [86]. Besides, CPAP can restore omentin-1 levels in the serum, and effective 3-month CPAP treatment can reverse low omentin-1 levels in patients with OSA [87].…”

Section: Correlation Between Osa and Omentin-1mentioning

confidence: 94%

Effects of different obesity-related adipokines on the occurrence of obstructive sleep apnea

2020

Endocr J

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Obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea during sleep and daytime sleepiness, seriously affects human health and may lead to systemic organ dysfunction. The pathogenesis of OSA is complex and still uncertain, but multiple surveys have shown that obesity is an important factor, and the incidence of OSA in people with obesity is as high as 30%. Adipokines are a group of proteins secreted from adipocytes, which are dysregulated in obesity and may contribute to OSA. Here, we review the most important and representative research results regarding the correlation between obesity-related adipokines including leptin, adiponectin, omentin-1, chemerin, and resistin and OSA in the past 5 years, provide an overview of these key adipokines, and analyze possible intrinsic mechanisms and influencing factors. The existing research shows that OSA is associated with an increase in the serum levels of leptin, chemerin, and resistin and a decrease in the levels of adiponectin and omentin-1; the findings presented here can be used to monitor the development of OSA and obesity, prevent future comorbidities, and identify risk factors for cardiovascular and other diseases, while different adipokines can be linked to OSA through different pathways such as insulin resistance, intermittent hypoxia, and inflammation, among others. We hope our review leads to a deeper and more comprehensive understanding of OSA based on the relevant literature, which will also provide directions for future clinical research.

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Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea

Abstract: OSAS is associated with low serum omentin levels, and these levels can be reversed by effective CPAP treatment.

Cited by 11 publications

References 21 publications

Omentin-A Novel Adipokine in Respiratory Diseases

Omentin-A Novel Adipokine in Respiratory Diseases

Serum levels of chemerin, omentin and vaspin in children with cystic fibrosis

Effects of different obesity-related adipokines on the occurrence of obstructive sleep apnea

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