Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Abstract

BackgroundAssociation between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk.MethodsPubMed, Embase and CNKI data were researched to conduct a meta-analysis on the associations between CCND1 G870A polymorphism and cervical cancer risk. Ten published case–control studies including 2,864 patients with cervical cancer and 3,898 controls were collected in this meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the relationship; meta-regression, sensitivity analysis and cumulative analysis were also conducted to guarantee the strength of results.ResultsOverall, no significant association between CCND1 G870A polymorphism and cervical cancer risk were found in allele contrast (A vs. G: OR = 1.02, 95% CI = 0.88-1.19, P = 0.76 I2 = 74.5%), codominant model (GA vs. GG: OR = 0.98, 95% CI = 0.77-1.26, P = 0.90 I2 = 69.1%; AA vs GG: OR = 1.03, 95% CI = 0.75-1.41, P = 0.85 I2 = 75.9%), dominant model (GA + AA vs. GG: OR = 1.00, 95% CI = 0.78-1.28, P = 0.99 I2 = 72.3%) and recessive model (AA vs GG + GA: OR = 1.06, 95% CI = 0.85-1.23, P = 0.62, I2 = 70.1%). Similarly, in the stratified analysis by ethnicity, study design and genotyping type, no significant association detected in all genetic models either.ConclusionsOur meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_168

Association between Cyclin D1 G870A (rs9344) polymorphism and cancer risk in Indian population: meta-analysis and trial sequential analysis

“…In another study, no significant association was reported between the CCND1 SNP (rs9344) and overall risk for cervical cancer in the Asian population but on stratification analysis by race, individuals carrying the AA or AA/AG genotypes showed a significant higher risk in comparison with GG carriers [ 32 ]. In parallel to the findings from the present study, Hu et al (2014) [ 30 ], also did not find the association of CCND1 G870A polymorphism and cervical cancer risk amongst different ethnic groups including Asian, Caucasian, and mixed in a cumulative meta-analysis.…”

“…However, these reports are conflicting thus we performed meta-analysis on the literature available in order to provide more accurate information on the role of CCND1 G870A (rs9344) polymorphism and overall cancer risk in Indian population. Although, various meta-analyses on individual cancer susceptibility have been published globally [ 30–35 ]. Pabalan et al (2008) [ 51 ], performed a meta-analysis on role of CCND1 polymorphism in different types of cancers and populations.…”

“…The outcomes of these studies were inconsistent in different ethnic groups. To overcome this conflict, several meta-analyses have been performed worldwide to see the effect of CCND1 polymorphism and risk for different types of cancer [ 30–35 ]. To the best of our knowledge, no report is available from India addressing the impact of CCND1 SNP and overall cancer risk.…”

Computational analysis of Cyclin D1 gene SNPs and association with breast cancer

“…Only one SNPs (rs9344) have been reported to have clinical significance. rs9344 is a synonymous SNP and has been associated as a risk factor SNP for different types of cancer [20][21][22][23][24][25] in different population including breast cancer [22,26]. In Chinese population, this SNP did not show to have a major association with breast cancer.…”