Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention

Sreedharan, Subhashaan; Чурилов, Леонид; Chan, Jianxiong; Todaro, Marian; Coulthard, Alan; Hocking, Jeffrey; Mahady, Kate; Mitchell, Peter; Dowling, Richard; Bush, Steven; Kwan, Patrick; Yan, Bernard

doi:10.1016/j.jstrokecerebrovasdis.2020.104901

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Several studies have reported this effect following the administration of the clopidogrel loading dose. [17][18][19][20][21][22][23][24] Factors such as; age, comorbidities, concomitant treatments, and body mass index, may explain less than 10% of this response variability. In this study population, demographic characteristics (age, Body Weight, Umbilical waist, body mass index), comorbidities (diabetes mellitus, lipid profile, hypertension, smoking) concomitant treatments (enoxaparin, statin, PPI, AEC inhibitor beta-blocker) were not associated with clopidogrel response.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies suggested an association of clopidogrel response with gene polymorphism involvement in clopidogrel metabolism and absorption. [20][21][22][23][24][25][26][27] Therefore, this study investigated the relationship between cytochrome P450 variants in CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, ABCB1, and clopidogrel response. Our data revealed that CYPs genotypes were not associated with clopidogrel response.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, CYP2C9 genotypes were also classified as PM (carriers of 2 mutated alleles), IM (carriers of *2 or *3 in heterozygosis), and NM (carriers of the *1/*1 genotype). 21 , 22 …”

Section: Methodsmentioning

confidence: 99%

“…Moreover, CYP2C9 genotypes were also classified as PM (carriers of 2 mutated alleles), IM (carriers of *2 or *3 in heterozygosis), and NM (carriers of the *1/*1 genotype). 21,22 For CYP2C19 genotypes were divided into three groups; NM (*1/*1), IM-PM (*1/*2, *2/*2, and *2/ *17), and UM (*1/*17 and *17/*17). CYP2C9 genotypes was also classified as NM (*1/*1), IM-PM (*1/*2, *1/*3, *2/*2 and *2/*3).…”

Section: Phenotypingmentioning

confidence: 99%

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Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Mouhrach,

Bouguenouch,

Kamal

et al. 2023

PGPM

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Introduction Clopidogrel is an antiplatelet prodrug primarily prescribed to prevent or treat acute coronary syndrome (ACS) or acute ischemic stroke (IS), polymorphisms of genes encoding cytochrome P-450 (CYP) and P-glycoprotein transporter, could affect the efficiency of clopidogrel absorption and biotransformation, especially during the first critical hours following its administration. Methods The present study was designed to investigate the potential association of clopidogrel responsiveness and 14 polymorphisms in the genes encoding the CYPs (CYP2C9, 2C19, 3A4, 3A5, 1A2, and 2B6), the ATP binding cassette subfamily B member 1 (ABCB1). Platelet aggregation activity was measured after 8h of 300mg clopidogrel administration for fifty-five ACS patients. Results There was no significant association between polymorphism of the studied CYPs and clopidogrel responsiveness (P>0.05). The frequency of the ABCB1 3435 T allele in clopidogrel non-responders was higher (78.9%) compared to responders (52.8%), but this difference was not significant (P=0.057). Demographic characteristics, comorbidities, concomitant treatments were not associated with clopidogrel response. Discussion There was no effect of the studied genetic variations and demographic factors on the platelet activity of clopidogrel in Moroccan ACS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Moreover, CYP2C9 genotypes were also classified as PM (carriers of 2 mutated alleles), IM (carriers of *2 or *3 in heterozygosis), and NM (carriers of the *1/*1 genotype). 21 , 22 …”

Section: Methodsmentioning

confidence: 99%

Section: Phenotypingmentioning

confidence: 99%

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Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Mouhrach,

Bouguenouch,

Kamal

et al. 2023

PGPM

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“… 7 A previous study reported a low risk of ischemic stroke for CYP2C but the underlying mechanisms were not discussed. 8 Additionally, there is evidence that polymorphisms in the CYP2CP gene are associated with stroke occurrence and recurrence in Spanish and Chinese populations. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Independent and Interactive Effects of Sex and CYP2C9 Variant rs4918758 on Ischemic Stroke Risk in Taiwan Biobank

Peng

Nfor

et al. 2022

IJGM

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Purpose Stroke is a complex health condition caused by multiple risk factors. We investigated whether the Cytochrome P450 2C9 ( CYP2C9 ) rs4918758 polymorphism and sex were independently and interactively associated with ischemic stroke risk among Taiwan Biobank (TWB) participants. Material and Methods We analyzed TWB data pertaining to 9197 female and 8625 male individuals. Data collected between 2008 and 2015 were linked to medical records in the National Health Insurance Database (NHIRD). Based on multiple logistic regression analyses, we estimated odds ratios (OR) and 95% confidence intervals (CI) for ischemic stroke. Results We found that 441 women and 468 men had ischemic stroke. There were no differences in the risk of ischemic stroke between individuals with the TC/CC genotype and those with the TT genotype [OR (95% CI) = 1.04 (0.90–1.21)]. When compared to women, men had an OR of 1.03 (95% CI = 0.87–1.22) for ischemic stroke. Based on further analysis, sex was found to interact with polymorphism rs4918758 (p for interaction = 0.0019). After categorizing by sex, men with TC/CC genotype showed significant ORs but not women [OR (95% CI) = 1.32 (1.07–16.33) vs 0.83 (0.68–1.00)]. Further stratification by genotype showed that in comparison with their female counterparts, men with the TT and TC/CC genotypes had ORs of 0.59 (95% CI = 0.44–0.80) and 1.36 (95% CI = 1.10–1.68), respectively. Conclusion According to our study, the TT genotype of rs4918758 was associated with a reduced risk of ischemic stroke in Taiwanese men when compared to women, whereas the TC/CC genotype was associated with a greater risk.

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Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: An ethnicity-based updated meta-analysis

Jafrin

Naznin

Reza

et al. 2021

European Journal of Internal Medicine

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Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention

Cited by 4 publications

References 35 publications

Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Independent and Interactive Effects of Sex and CYP2C9 Variant rs4918758 on Ischemic Stroke Risk in Taiwan Biobank

Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: An ethnicity-based updated meta-analysis

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