Association between demyelinating disease and autoimmune rheumatic disease in a pediatric population

Caparroz, Ana Luíza Mendes Amorim; Cabral, Nádia Canale; Osaku, Fabiane Mitie; Len, Cláudio Arnaldo; Oliveira, Enedina Maria Lobato de; Terreri, Maria Teresa

doi:10.1016/j.rbre.2016.09.016

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After evaluating 423 reported NMOSD patients, Raynaud"s phenomenon was the most common associated skin disorder [143]. Other cutaneous disorders such as dermatomyositis [144][145][146], dermatitis herpetiformis [72,133,143], pemphigus foliaceus [147], psoriasis [73,139], bullous pemphigoid, pyoderma gangrenosum, vitiligo, atopic dermatitis, alopecia aerate [73,148], and limited scleroderma [29], have been reported to be associated with NMOSD.…”

Section: -2-3-skin Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi

Doosti

Shahmohammadi

et al. 2019

Multiple Sclerosis and Related Disorders

144

View full text Add to dashboard Cite

Section: -2-3-skin Disordersmentioning

confidence: 99%

“…Inflammatory myopathies such as polymyositis [64,148] and dermatomyositis with typical skin features and proximal weakness [144,145] without underlying neoplasm have been reported.…”

Section: -2-5-myopathiesmentioning

confidence: 99%

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi

Doosti

Shahmohammadi

et al. 2019

Multiple Sclerosis and Related Disorders

144

View full text Add to dashboard Cite

“…The monitoring and replacement of deficient levels of ANA, vitamin D, and folate are important for the course of autoimmune diseases such as multiple sclerosis. The screening test of ANA must first be evaluated in patients under suspicion of having an autoimmune disease [11,12]. The confirmatory tests are the extractable nuclear antigen (ENA) and anti-dsDNA tests, which are studied as an enzyme-linked immunosorbent assay (ELISA) in routine laboratories after the detection of ANA positivity.…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies and Vitamin Levels: Is A Player Or Not in Pathophysiology of Multiple Sclerosis Patients?

Türkoğlu¹,

Öğün²,

Karabörk³

et al. 2018

Arch Clin Biomed Res

View full text Add to dashboard Cite

Introduction and Aim: Multiple sclerosis is a demyelinating autoimmune disease of the central nervous system. ANA, anti-dsDNA, and ENA profiles have been used in the diagnosis and treatment of autoimmune diseases. Low vitamin D and B12, and folate levels, and high homocysteine levels are often detected in autoimmune diseases. In the present study, we aimed to investigate these parameters in patients with Multiple sclerosis and Multiple sclerosis like disease, as diagnosed in accordance with the revised McDonald criteria. Methods:The laboratory results of 161 (53Multiple sclerosis, 108 Multiple sclerosis like) patients who were examined for the differential diagnosis of vasculitis/Multiple sclerosis in the last 14 months were evaluated in this present retrospective, cross-sectional study. ANA, anti-dsDNA, ENA profile, vitamin D and B12, folic acid, and homocysteine levels were recorded.Results: ANA levels in 12 patients with Multiple sclerosis and in 34 patients with Multiple sclerosis like disease were positive; however, ANA levels were negative in 37 patients Multiple sclerosis, and 72 patients with Multiple sclerosis like disease. Anti-dsDNA levels in 4 patients Multiple sclerosis and in 23 with Multiple sclerosis like disease were positive; however, they were negative in 44 patients with Multiple sclerosis and 81 with Multiple sclerosis like disease. The mean vitamin B12 and D, and folate levels of 111 patients were found below the lower normal limit, whereas PTH and homocysteine levels were found over the upper normal limit.

show abstract

Pediatric Neuromyelitis Optica Spectrum Disorders

Gombolay

Chitnis

2018

Curr Treat Options Neurol

View full text Add to dashboard Cite

The aquaporin-4 antibody (AQP4 ab) is specific for NMOSD; however, recently another antibody, the myelin oligodendrocyte glycoprotein (MOG ab) has been found in a subset of AQP4 ab-negative patients including in children. Most treatment studies are reported in adults, but retrospective studies on efficacy and safety of mycophenolate mofetil, azathioprine, and rituximab in pediatric NMOSD are available. While some pediatric NMOSD-specific treatment studies are available, more research is needed in the mechanisms of early onset and specific treatment options in children, including whether different treatment considerations are needed for AQP4 ab as opposed to MOG ab-positive disease.

show abstract

Association between demyelinating disease and autoimmune rheumatic disease in a pediatric population

Abstract: Among patients with demyelinating diseases diagnosed in childhood included in this study there was a high frequency of antinuclear antibody positivity but a lower association with rheumatologic autoimmune diseases than that observed in studies conducted in adults.

Cited by 3 publications

References 19 publications

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Autoantibodies and Vitamin Levels: Is A Player Or Not in Pathophysiology of Multiple Sclerosis Patients?

Pediatric Neuromyelitis Optica Spectrum Disorders

Contact Info

Product

Resources

About