Association between developmental defects of enamel and celiac disease: A meta-analysis

Souza, Débora Souto; Soares, Maria Eliza da Consolação; Rezende, Vanessa Silva de; Dantas, Paulo César de Lacerda; Galvão, Endi Lanza; Falci, Saulo Gabriel Moreira

doi:10.1016/j.archoralbio.2017.12.025

Cited by 29 publications

(31 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Celiac disease (CD) is an immune-mediated enteropathy that affects genetically susceptible people following exposure to dietary gluten. 1 , 2 , 3 , 4 , 5 , 6 , 7 CD individuals may have gastrointestinal symptoms with a typical enteropathy, characterized by a malabsorption syndrome, extraintestinal symptoms or none of these. 6 , 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population

Macho

Manso

Silva

et al. 2020

Journal of Dental Sciences

View full text Add to dashboard Cite

Background/purpose Dental enamel defects are related to celiac disease and the dentists are in a perfect situation to identify and report suspected cases. The aim was to evaluate the symmetry of enamel defects in a pediatric Portuguese population with celiac disease and compare it with healthy controls. Materials and methods a case-control study was performed in 80 patients with celiac disease and 80 healthy individuals aged 6–18 years old as controls. Data was collected by a questionnaire and clinical observation. Colour, type, and site of enamel defects were recorded and classified according to Aine criteria. Data analysis was performed, and any p-value <0.05 was considered significant. Results Enamel defects were found in 55% of patients with celiac disease and 27.5% in the control individuals (p < 0.001). Grade I of Aine's classification was the most found in both groups, but it was higher in the celiac disease group, not only in the permanent dentition, but also in both dentitions with statistically significant difference (p = 0.002 and p = 0.001 respectively). Grade II was found only in the celiac disease group. It was observed that enamel defects in celiac disease were symmetric and the most affected teeth were the first permanent molars (p = 0.003) and the permanent incisors (p = 0.001). Conclusion Symmetric dental enamel defects in population with celiac disease are more predominant than in general population. Therefore, individuals with enamel defects, especially those with symmetric lesions, should be well evaluated and the possibility of having celiac disease in the clinical history must be taken into account.

show abstract

Section: Introductionmentioning

confidence: 99%

The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population

Macho

Manso

Silva

et al. 2020

Journal of Dental Sciences

View full text Add to dashboard Cite

show abstract

“…Dental enamel defects (DED) are reported to be more common in children and adults with CD compared to the general population, and may occur in the absence of gastrointestinal symptoms (3). In a recent systematic review of extra-intestinal manifestations of CD, including 2840 patients, the prevalence of dental enamel defects in people with CD was 50% (4). In a study by Wierink et al on 53 Dutch children with proven CD, 55% had enamel defects compared to 18% in control subjects (5).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Prevalence of Dental Enamel Defects and Other Oral Findings in Children with and Without Celiac Disease

et al. 2018

View full text Add to dashboard Cite

Background: Dental enamel defects and other oral manifestations are reported to occur more commonly in children with celiac disease (CD). Our aim was to investigate the frequency and distribution of enamel defects and dental caries, and the presence of other oral findings in children with CD and to compare them to a group of children without CD. Methods: From 200 index cases with CD, 65 cases aged between three to 16 years accepted to participated in the study after an oral explanation for the parents. In addition, 60 healthy, age, and sex matched subjects without CD were chosen as control group. Enamel defects were classified according to the Aine criteria and dental caries was recorded by calculation of DMFT/dmft indices. The presence of other oral findings, such as aphthous ulcers and xerostomia, were recorded. Chi-Square test and Mann-Whitney test were used for comparison of data. P values < 0.05 were considered statistically significant. Results: A total of 65 children with CD and 60 non-CD subjects were studied. There were significantly more enamel defects in children with CD compared to the control group (P = 0.01). Grade I was the most common enamel defect in both groups. Symmetric and non-specific enamel defects were observed in 45% and 14% of CD subjects and in 12% and 12% of the control group (P = 0.001). The location of enamel defects in permanent and deciduous teeth was more prominent in anterior teeth with a coronal distribution involving the incisor and middle parts of the teeth. The dmft index was significantly higher in the control group compared to the CD group (P = 0.003). With the exception of xerostomia, there was no difference in other oral manifestations between groups. Conclusions: Enamel defects are more common in children with CD compared to those without this disease. This finding should alert health care providers to consider testing for CD.

show abstract

“…Dental hard tissue manifestations in CD patients are various; we can find alterations on the enamel and teeth structure. Some studies report enamel hypoplasia, enamel defect or enamel and dental structure alterations [ 38 – 40 , 42 – 44 ], this condition puts CD patients in condition of discomfort, lowering their general conditions of oral health and expelling them to other debilitating diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies evaluated the oral health of patients through self-administered tests like the OHIP-14 test (Oral Health Impact Profile 14) or XI test (Xerostomia inventory). Studies reported abnormalities in general oral health like DMFT index (Decayed, Missing, Filled Teeth); some other studies reported anomalies like delayed eruption and parodontal disease [ 36 – 42 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oral Health Impact Profile in Celiac Patients: Analysis of Recent Findings in a Literature Review

Cervino

Fiorillo

Laino

et al. 2018

Gastroenterology Research and Practice

View full text Add to dashboard Cite

The increment of recording atypical oral manifestation in young patients often related to systematic disease is today a challenge for the therapists. Sometime, the presence of tooth enamel lesions correlated with soft tissue lesions is just a symptom or a trigger sign for a deeper and undetermined disease. Recently, high impact has been developed toward the influence of the diet as a controlled and modifiable factor in patients affected by celiac pathologies. The celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in genetically predisposed patients. Gluten is a proline-rich and glutamine-rich protein present in wheat (gliadin), barley (hordein), and rye (secalin). The gluten-free diet (GFD) seems to better influence the oral health status of the CD patients. For this reason, the main objective of this revision was to analyze the international data highlighting the relationship between celiac patients and the oral health impact profile. A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in the English language published from 2008 to 2018. The first analysis with filters recorded 67 manuscripts accordingly with the selected keywords. Finally, a number of 16 appropriate published papers were comprehended in the review. The studies were different in terms of the structure, findings, outcomes, and diet quality evaluation, and for this reason, it was not possible to accomplish a meta-analysis of the recorded data. This manuscript offers some observational evidence to justify the advantages of gluten-free diets related to a better oral health status in the patients involved.

show abstract

Association between developmental defects of enamel and celiac disease: A meta-analysis

Cited by 29 publications

References 47 publications

The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population

The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population

A Comparison of the Prevalence of Dental Enamel Defects and Other Oral Findings in Children with and Without Celiac Disease

Oral Health Impact Profile in Celiac Patients: Analysis of Recent Findings in a Literature Review

Contact Info

Product

Resources

About