Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan

Kobayashi, Minatsu; Otani, Tetsuya; Iwasaki, Motoki; Natsukawa, Shusuke; Shaura, Kozo; Koizumi, Yukio; Kasuga, Yoshio; Sanada, Hiromi; Yoshida, Teruhiko; Tsugane, Shoichiro

doi:10.1007/s10120-009-0523-x

Cited by 25 publications

(13 citation statements)

References 30 publications

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“…24 However, three Chinese studies [25][26][27] and one Japanese study 28 did not show any association. Moreover, Kobayashi et al 29 showed that the association was not found even after controlling for several potential confounding factors, such as tobacco smoking, in a Japanese case-control study. However, the exonic CYP1A1 (rs4646422) polymorphism has been found to replace glycine with aspartic acid by the missense allele at codon 45.…”

Section: Discussionmentioning

confidence: 97%

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CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Hidaka¹,

Sasazuki²,

Matsuo

et al. 2016

Intl Journal of Cancer

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Cytochrome P450 (CYP) 1A1 and glutathione S-transferases (GST) M1 and T1 are major enzymes in the carcinogen metabolizing pathway. We examined the association between single nucleotide polymorphisms (SNPs) of CYP1A1 (rs4646421, rs4646422 and rs1048943), GSTM1 and GSTT1 and gastric cancer risk in Japan. This is a nested case-control study (457 cases and 457 matched controls) of our population-based cohort involving 36,745 subjects who answered a baseline questionnaire and supplied blood samples. The odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated using conditional logistic regression models. We found that CYP1A1 (rs4646422) variant allele was associated with a statistically significant increased risk of gastric cancer compared with the homozygous wild-type genotype (OR 5 1.65; 95% CI 5 1.17-2.32). GSTM1 null, GSTT1 null and GSTM1/T1 both or either null genotypes were associated with increased risk, but not statistically significantly. Combination of the CYP1A1 (rs4646422) variant allele and GSTM1/T1 both or either null genotypes was associated with a statistically significant increased risk compared with the combination of the CYP1A1 homozygous wild-type genotype and the GSTM1/T1 both active genotypes. In addition, compared with CYP1A1 (rs4646422) homozygous wild-type genotypes in those who were never-smokers, CYP1A1 variant alleles in those who smoked 30 pack-years were associated with an increased risk; neither gene-gene nor gene-environment interactions were significant. The CYP1A1 (rs4646422) polymorphism might be involved in gastric carcinogenesis among the Japanese population.According to the International Agency for Research on Cancer, tobacco is classified as a carcinogenic agent; sufficient evidence of this exists in humans.1 Tobacco contains multiple chemical substances such as polycyclic aromatic hydrocarbons (PAHs), N-nitrosamines and heterocyclic amines. 2PAHs are also contained in polluted air (exhaust fumes) 3 and grilled food, 4 among others. The carcinogenetic effect of exposure to PAH was reported in in vivo and in vitro studies. 5 In a recent prospective study, higher concentrations of 1-hydroxypyrene glucuronide, which is a PAH metabolite, were associated with increased risk of gastric cancer among Chinese individuals.

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Section: Discussionmentioning

confidence: 97%

“…However, three Chinese studies and one Japanese study did not show any association. Moreover, Kobayashi et al . showed that the association was not found even after controlling for several potential confounding factors, such as tobacco smoking, in a Japanese case–control study.…”

Section: Discussionmentioning

confidence: 97%

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Hidaka¹,

Sasazuki²,

Matsuo

et al. 2016

Intl Journal of Cancer

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“…It is possible that low enzyme activity in the individuals with SULT1A1 His/His genotype may result in less detoxification of HCAs from high consumption of grilled/barbequed meat [39] . However, Kobayashi et al [40] did not find any interaction between the consumption of grilled or barbequed meat and polymorphisms in NAT2, CYP1A1, and CYP1A2. The authors assumed that the relatively low intake of HCAs among the Japanese might have affected the findings.…”

Section: Effect Of Carcinogen Metabolism-related Genetic Polymorphismmentioning

confidence: 99%

“…Alcohol drinking modified the association between MTHFR C677T and GC risk (P interaction = 0.09) Lacasaña-Navarro et al [21] , Alcohol drinkers carrying the variant allele of CYP2E1 (*5A or *6 alleles) had an increased GC risk compared to those drinking without the variant allele (P for heterogeneity = 0.001) Kobayashi et al [40] , 2009, Japan 149/296 (Hospital)…”

Section: Unknownmentioning

confidence: 99%

Gene-diet interactions in gastric cancer risk: A systematic review

Kim¹,

Cho²,

Choi³

et al. 2014

WJG

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AIM:To conduct a systematic review of the published epidemiological studies investigating the association of the interactions between gene variants and dietary intake with gastric cancer risk. METHODS:A literature search was conducted in PubMed, EMBASE, and MEDLINE for articles published between January 2000 and July 2013, and 38 studies were identified. Previous studies included various dietary factors (e.g. , fruits and vegetables, soybean products, salt, meat, and alcohol) and genetic variants that are involved in various metabolic pathways. RESULTS:Studies suggest that individuals who carry high-risk genetic variants and demonstrate particular dietary habits may have an increased risk of gastric cancer compared with those who do not carry high-risk genetic variants. Distinctive dietary patterns and variations in the frequency of genetic variants may explain the higher incidence of gastric cancer in a particular re-SYSTEMATIC REVIEWS 9600July 28, 2014|Volume 20|Issue 28| WJG|www.wjgnet.com gion. However, most previous studies have limitations, such as a small sample size and a retrospective casecontrol design. In addition, past studies have been unable to elucidate the specific mechanism in gene-diet interaction associated with gastric carcinogenesis. CONCLUSION:Additional large prospective epidemiological and experimental studies are required to identify the gene-diet metabolic pathways related to gastric cancer susceptibility. Key words: Gastric cancer; Gene; Diet; Interaction Core tip: Gene-diet interactions related to gastric carcinogenesis may provide a unique environment for cancer growth or suppression in each individual. Gene-diet interactions may explain the large variation in gastric cancer incidence in different populations and the inconsistent findings of previous gene or diet studies. Therefore, this review provides an overview of the published epidemiological studies that have investigated the interactions between gene variants and dietary factors associated with gastric cancer risk.

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“…Heterocyclic aromatic amines, in turn, are formed through the condensation of creatine/creatinine and the strecker degradation radicals (pyridines and pyrazines) generated from the reaction of sugars and amino acids during the Maillard reaction [49]. The present findings are worrisome, because meat-cooking habits have been linked with several forms of cancer [50,51,52,53]. In Argentina, for example, cooking meat at a high temperature and close to the cooking source has been linked with increased incidence of colorectal cancer [54].…”

Section: Discussionmentioning

confidence: 89%

Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals

Omoruyi

Ahamioje

Pohjanvirta

2014

IJERPH

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Food and drinking water are poorly delineated sources of human exposure to chemical food mutagens and endocrine-disrupting chemicals. In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in vitro assays. Commercially processed foods or snacks and various brands of pure water sachets were extracted by solid-phase extraction and liquid-liquid extraction, respectively. Mutagenicity was determined by the conventional Ames test and two complementary assays on two strains of Salmonella (TA 100 and TA 98), while the estrogenic activity was assessed by a yeast bioluminescent assay, using two recombinant yeast strains (Saccharomyces cerevisiae BMAEREluc/ERα and S. cerevisiae BMA64/luc). A third of the food varieties investigated (chin-chin, hamburger, suya and bean cake) were mutagenic in all three assays, either in the presence or absence of S9 mix. Of the packed water samples, five out of the sixteen investigated (31%), were found to be estrogenic, with estradiol and bisphenol A equivalents ranging from 0.79 to 44.0 ng/L and 124.2 to 1,000.8 ng/L, respectively. Hence, although the current situation in Nigeria does not appear to be substantially worse than, e.g., in Europe, regular monitoring is warranted in the future.

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Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan

Cited by 25 publications

References 30 publications

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Gene-diet interactions in gastric cancer risk: A systematic review

Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals

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