Association Between Dietary Inflammatory Index and Mental Health: A Systematic Review and Dose–Response Meta-Analysis

Chen, Guoqiang; Peng, Chunling; Lian, Ying; Wang, Bowen; Chen, Pengyu; Wang, Gang-Pu

doi:10.3389/fnut.2021.662357

Cited by 26 publications

(27 citation statements)

References 90 publications

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“…Overall, the associations are consistently positive for depression and severe mental illness. They are not as consistent for anxiety (23). So, the results from this study are somewhat inconsistent with previous results.…”

Section: Discussioncontrasting

confidence: 99%

“…In addition to the positive association between the DII score and risk of cardiometabolic diseases ( 22 ), a comprehensive evaluation of current evidence indicated that higher DII was associated with an increased risk of common mental health outcomes, including depression, symptoms of anxiety, and distress, as well as schizophrenia in adults ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

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Higher Dietary Inflammatory Index Scores Are Associated With Stress and Anxiety in Dormitory-Residing Female University Students in the United Arab Emirates

et al. 2022

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Dormitory-residing university students are at-risk of mental health problems related to unhealthy diets. The purpose of this study was to assess the association between dietary inflammatory potential and mental health of dormitory-residing female university students. This cross-sectional study was comprised of 260 undergraduate females residing in dormitories of the largest university in United Arab Emirates during Spring 2019. The Energy-adjusted Dietary Inflammatory Index (E-DIITM) scores calculated from 37 food parameters were derived from two 24-h dietary recalls. The logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs for the E-DII score in relation to depression, anxiety, and stress. The E-DII scores (mean = 2.98 ± 1.17) were categorized into: tertile 1 (−1.96–2.62), tertile 2 (2.63–3.52), and tertile 3 (3.53–5.60), representing less to more proinflammatory diets. Students in the E-DII tertile 3 had significantly higher depression, anxiety, and stress scores. The logistic regression analysis showed that each point increase in the E-DII score was associated with symptoms of stress (OR = 1.41; 95% CI: 1.12–1.77; p = 0.003) and anxiety (OR = 1.35; 95% CI: 1.07–1.69; p = 0.01). Relative to students in the E-DII tertile 1, those students in the E-DII tertile 3 were more likely to be at higher risk of stress and anxiety ORE−DIItertile3vs1 = 2.89 (1.44–5.79) and 2.88 (1.49–5.56), respectively. Overall, stress and anxiety were associated with proinflammatory diets in dormitory-residing female university students, suggesting the need for targeted interventions to increase the anti-inflammatory capacity of diet and improve mental wellbeing in students on university campuses.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Higher Dietary Inflammatory Index Scores Are Associated With Stress and Anxiety in Dormitory-Residing Female University Students in the United Arab Emirates

et al. 2022

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“…Recent study has demonstrated that dietary inflammatory index (DII) is inversely associated with depression ( 7 ). One meta-analysis showed that a 1-unit increment in DII was associated with an increased risk of 6% for depressive symptoms ( 35 ). Previous research also indicated that increased risk of depression was associated with the Western diet, characterized by consumption of high red and processed meat and refined carbohydrates, and decreased risk of depression with the Mediterranean diet, represented by high amount of fruit, vegetables, and whole grains ( 36 , 37 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

et al. 2022

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Depressive symptoms are major public health problems. Leisure-time Physical activity (LPA) and dietary inflammatory preference are emerging factors that tends to affect the mental health status. There is limited evidence regarding the joint influence of LPA and dietary status on the prevalence of depression. This study was a cross-sectional study, which used a nationwide represented sample from the National Health and Nutrition Examination Survey (NHANES) to assess the relationship among LPA, diet status and depression. Depression and LPA status was reported by the 9-item Patient Health Questionnaire (PHQ-9) and Physical Activity Questionnaire (PAQ), respectively. To assess dietary inflammatory preferences, dietary inflammatory index (DII) was applied based on a 24-h dietary recall interview. A total of 11,078 subjects was included in this study and weighted participants were 89,682,020. Weighted multivariable linear regression showed that DII was negatively associated with LPA after full adjustment, with β (95% CI): −0.487 (−0.647, −0.327). Weighted multivariable logistic regression showed that LPA was significantly associated with depressive symptoms after full adjustment, with odds ratios OR (95% CIs): 0.986 (0.977, 0.995). By DII stratification analysis, this phenomenon was also existed in groups with anti-inflammatory diet. Mediation effect analysis was further performed, which showed that DII significantly mediating the association between LPA and depression with proportion mediated as 3.94%. Our findings indicated the mediating role of DII in the association between LPA condition and incident depression. More well-designed studies are still needed to validate the causal relationship.

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“…The finding indicated that a higher DII score was related to the higher risk of depressive symptoms, which in turn, led to sarcopenia independent of the direct effects of DII on sarcopenia. Similarly, our previous meta-analysis showed that a pro-inflammatory diet was associated with an increased risk of common mental health outcomes, such as depressive symptoms, anxiety, distress, and the association presented in a dose-response manner (32). Potential mechanisms underlying the association between DII and depressive symptoms may include oxidant-antioxidant imbalance and modified gut microbiota composition and activity (33,34).…”

Section: Discussionmentioning

confidence: 74%

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

2022

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BackgroundSarcopenia is a major public health problem. Depressive symptoms and dietary inflammatory potential play important roles in the development of sarcopenia. We aimed to disentangle the relationships between depressive symptoms, dietary inflammatory potential, and sarcopenia.MethodsA total of 6,082 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sarcopenia was defined according to the Foundation for the National Institutes for Health (FNIH) criteria. The Depressive symptoms were assessed using the nine-item Patient Health Questionnaire (PHQ-9). Dietary Inflammatory Index (DII) was calculated based on 24-h dietary recall interview. Two sets of mediation models were constructed separately.ResultsDepressive symptoms and DII were associated with sarcopenia, with odds ratios [ORs] (95% CIs) 2.54 (1.27, 5.13) and 1.17 (1.00, 1.37), respectively. DII score mediated the association of depressive symptoms with low muscle mass, explaining a total of 10.53% of the association (indirect effect = 0.004). Depressive symptoms had a significant mediating effects on the association between DII with low muscle mass, explaining a total of 12.50% of the association (indirect effect = 0.001).ConclusionsOur findings suggested that both depressive symptoms and dietary inflammatory potential had direct effects, and indirect effects on low muscle mass, handgrip strength, muscle mass, through each other. It provides important insights into integrated nutritional and psychological intervention strategies in preventing sarcopenia.

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Association Between Dietary Inflammatory Index and Mental Health: A Systematic Review and Dose–Response Meta-Analysis

Cited by 26 publications

References 90 publications

Higher Dietary Inflammatory Index Scores Are Associated With Stress and Anxiety in Dormitory-Residing Female University Students in the United Arab Emirates

Higher Dietary Inflammatory Index Scores Are Associated With Stress and Anxiety in Dormitory-Residing Female University Students in the United Arab Emirates

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

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