Association Between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis

Machado, Vanessa; Botelho, João; Viana, João; Pereira, Paula; Lopes, Luísa Bandeira; Proença, Luís; Delgado, Ana Sintra; Mendes, José João

doi:10.20944/preprints202011.0455.v1

Cited by 4 publications

(1 citation statement)

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“…Moreover, proinflammatory dietary patterns such as red meat, processed meat, etc. were found to be associated with an increased risk of periodontitis (Li et al, 2021;Machado et al, 2021). Among the younger population higher intake of added sugars may increase the risk of periodontitis (Lula et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Yang,

Wang,

Hong

et al. 2024

Front. Genet.

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BackgroundPeriodontitis, a complex inflammatory condition, has been associated with dietary habits and antioxidants. While the association between certain dietary patterns and periodontitis has been documented, the bidirectional relationship remains unclear. This study utilizes Mendelian randomization (MR) analysis to investigate the bidirectional associations between dietary factors comprising dietary antioxidants, and periodontitis.MethodsEmploying a two-sample MR approach, this study analyzed genome-wide association study (GWAS) data on diets and periodontitis from large databases and published literature. Instrumental variables (IVs) were selected and filtered based on genetic variants associated with dietary factors and periodontitis, respectively. Various MR methods, including Inverse Variance Weighted, MR-Egger, Weighted Median, Weighted Mode, and Simple Mode were applied to assess the bidirectional associations. Sensitivity analyses were conducted to validate the robustness of the findings.ResultsOur analysis revealed significant associations between certain dietary factors and the risk of periodontitis. Specifically, higher intake of filtered coffee, low-calorie drinks, and other cereals, as well as increased metabolic circulating levels of gamma-tocopherol, were associated with an elevated risk of periodontitis. Conversely, consumption of cheese, white rice, chocolate bars, unsalted peanuts, and higher absolute circulating levels of vitamin C were linked to a reduced risk. Additionally, the study suggests that periodontitis may influence dietary habits, indicating a bidirectional relationship.ConclusionThis study provides additional evidence of a bidirectional association between dietary factors and periodontitis. It highlights the importance of dietary interventions in the prevention and management of periodontitis. The findings underscore the need for incorporating dietary counseling into periodontal disease management protocols and suggest the potential of personalized dietary strategies for periodontitis patients. Further research is warranted to explore the mechanisms underlying these associations and to confirm these findings in diverse populations.

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Section: Introductionmentioning

confidence: 99%

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Yang,

Wang,

Hong

et al. 2024

Front. Genet.

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Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts

Lyra¹,

Botelho²,

Machado³

et al. 2022

npj Parkinsons Dis.

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Periodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has never been studied within Parkinson’s Disease (PD). The aim of this study is to compare hs-CRP levels of self-reported periodontitis cases versus cases without periodontitis in PD patients. Data from the National Health and Nutrition Examination Survey (2015–2016 and 2017–2018 waves) were analyzed. PD cases were identified through medication regimens and periodontitis cases through a validated self-report questionnaire. 51 participants were included (24 females, 27 males, with mean age of 62.96 (14.71)). While the self-reported periodontitis group presented elevated levels of circulating hs-CRP (5.36 vs. 1.99 mg/L, p = 0.031), the self-reported without periodontitis group presented higher lymphocyte levels (29.35 vs. 28.03%, p = 0.007). Blood levels of hs-CRP were significantly higher in PD cases with self-reported periodontitis. Apart from the lymphocyte levels, there were no other significant differences according to the self-reported periodontal status. Future studies shall explore this association using clinical measures.

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Self-Reported Measures of Periodontitis in a Portuguese Population: A Validation Study

Machado

Lyra²,

Santos³

et al. 2022

JPM

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Self-reported questionnaires have been developed and validated in multiple populations as useful tools to estimate the prevalence of periodontitis in epidemiological settings. This study aimed to explore the accuracy of self-reporting for predicting the prevalence of periodontitis in a Portuguese population. The questionnaires were given to patients at a university clinic. Thirteen self-reported questions on periodontal health were gathered in a patient-reported questionnaire. Then, self-reporting responses were validated using full-mouth periodontal examination as a comparison. Multivariable logistic regression was used to analyze sensitivity, specificity, accuracy, precision, and area under the curve-receiver operator characteristic (AUC-ROC). Self-reported answers from 103 participants (58 females and 45 males) were included. Self-reported gum health, loose teeth, tooth appearance, and use of dental floss were associated with different definitions of severe periodontitis. The self-reported questions on “having gum disease,” combined with “having gum treatment” and “having lost bone” were the items with higher performance for the 2018 case definition and the 2012 case definition, as well as for each respective severity staging. Categorization of tooth loss was only valuable for the prediction of periodontitis cases according to the 2012 case definition and its severe stage. Multiple self-reporting set-ups showed elevated performance levels for predicting periodontitis in Portuguese patients. These results may pave the way for future epidemiological surveillance programs using self-reporting approaches.

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Association Between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis

Cited by 4 publications

References 48 publications

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts

Self-Reported Measures of Periodontitis in a Portuguese Population: A Validation Study

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