Association Between Eczema and Increased Fracture and Bone or Joint Injury in Adults

Abstract

The results of this study suggest that eczema in adulthood is a previously unrecognized risk factor for fracture and other injury causing limitation. Future studies are needed to confirm these associations. The findings may warrant the development of preventive measures for injury risk reduction in adult patients with eczema.

Assessment of atopic dermatitis using self-report and caregiver report: a multicentre validation study

“…Understanding the epidemiology of atopic dermatitis (AD or eczema) is essential for identifying at‐risk populations and potentially modifiable risk factors, and ultimately in developing interventions that could prevent eczema in the general population. Much of our knowledge of the epidemiology of eczema in the U.S.A. comes from a number of US population‐based studies, which analysed data from the National Survey of Children's Health (NSCH), National Health Interview Survey (NHIS) and National Health and Nutrition Examination Survey (NHANES) . These studies employed different approaches to identifying eczema, including caregiver‐ and self‐reported diagnosis of eczema ever (NHANES) or in the past year (NSCH and NHIS).…”

“…Much of our knowledge of the epidemiology of eczema in the U.S.A. comes from a number of US populationbased studies, which analysed data from the National Survey of Children's Health (NSCH), National Health Interview Survey (NHIS) and National Health and Nutrition Examination Survey (NHANES). [1][2][3][4][5][6][7][8][9][10][11][12] These studies employed different approaches to identifying eczema, including caregiver-and self-reported diagnosis of eczema ever (NHANES) or in the past year (NSCH and NHIS). While previous studies validated different questionnaires for self-and caregiver-reported eczema, 13,14 the validity of the particular questions employed by NSCH, NHIS and NHANES has not previously been investigated.…”

Long-term use of ciclosporin in a real-world setting

“…[1][2][3] Adults with moderate-to-severe AD have been shown to have poorer health status, 1 sleep disturbances, 1 higher rates of fractures and other injuries, 4 obesity and other cardiovascular disease risk factors, 5,6 and depression and other mental health comorbidities. 7 The mainstays of treatment for AD are emol-lients, topical corticosteroids, calcineurin inhibitors and avoidance of exacerbants.…”

“…For example, taurolidine 2% was shown to be active against Aspergillus fumigatus isolates and used for pleural decontamination during surgery for chronic pulmonary aspergillosis. 4 However, although the newer generation of surgical antiseptics is much safer, hydrogen peroxide has recently been attributed to causing a massive gas embolism during surgery. 5 Understanding the clinical significance of antiseptics in mycetoma management will determine potential for this previously unexplored therapeutic avenue to be formalized.…”

Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: A US population‐based study

“…A study of 27,556 children aged 0–5 yrs from the National Survey of Children's Health found that children with AD and/or allergic disease had higher odds of serious injury requiring medical attention, which was partially mediated by psychologic and behavioral disorders . Similarly, a study 27,556 adults from the National Health Interview Survey found that adults with eczema had higher odds of fractures, bone and joint injuries, particularly in those with sleep disturbances and psychologic and behavioral disorders . These studies suggest that patients with AD may have decreased BMD, thereby predisposing to increased fractures.…”