Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine

García‐Martín, Elena; Navarro-Muñoz, Santiago; Rodriguez, Christopher; Serrador, Mercedes; Alonso‐Navarro, Hortensia; Calleja, Marisol; Turpín-Fenoll, Laura; Recio-Bermejo, Marta; Garcia-Ruiz, Rafael; Millán-Pascual, Jorge; Navacerrada, Francisco; Plaza-Nieto, José Francisco; E, García-Albea; Agúndez, José A. G.; Jiménez‐Jiménez, Félix Javier

doi:10.1038/s41397-019-0133-x

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…It is a complicated neurovascular disorder, which involves multiple cortical, subcortical and brainstem areas of the brain (1) . Previous experimental studies have suggested an important role for NO in migraine pathogenesis (4) . The trigeminovascular system inflammation, which occurs during migraine attacks, and also the dilation of cerebral vessels, has been attributed to the role of NO in the central nervous system (5) .…”

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confidence: 99%

Is there a relationship between dietary sodium and potassium intake and clinical findings of a migraine headache?

et al. 2021

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Aim: Few studies have assessed the association between sodium (Na) and potassium (K) and migraine headaches. In this study, we aimed to examine the relationship between 24-hour urine Na and K intakes and clinical findings of migraine in an Iranian sample. Methods: In this cross-sectional study, 262 participants, aged 20-50 years, were included with a body mass index (BMI) of 18.5-30 kg/m2 and a diagnosis of migraine. One 24-hour urine sample was collected from each subject to estimate the Na and K intakes. The clinical features of migraine, including frequency, duration, severity, Migraine Headache Index Score (MHIS), and Headache Impact Test (HIT) score, were assessed. Besides, a multiple linear regression analysis was performed, and beta estimates and the corresponding 95% confidence intervals (CIs) were reported. Results: Overall, 224 women and 38 men, with a mean age of 36.10 years and BMI of 25.55 kg/m2 comprised our study population. After controlling for potential confounders, the 24-hour urine Na was positively associated with a longer headache duration (β=0.29; 95% CI: 0.06, 0.53) in the group with the highest urine Na levels as compared to the group with the lowest levels. After adjustments for potential confounders, an increase of 13.05 in the MHIS was observed when the 24-hour urine Na level increased from the first to the third tertile (β=13.05; 95% CI: 1.70, 24.41). Conclusion: Our findings suggested that a higher 24-hour urine Na level was positively associated with a longer duration of migraine headaches and a higher MHIS.

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confidence: 99%

Is there a relationship between dietary sodium and potassium intake and clinical findings of a migraine headache?

et al. 2021

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“…The authors used the results of a meta-analysis by Dong et al [21] and studied SNV rs2070744 in representatives of the Caucasian race in Spain. However, the frequencies of alleles and genotypes did not differ significantly between the main and control groups (for the minor allele OR 0.91, CI 0.72-1.12, p = 0.418), although it was shown that homozygotes for the minor C allele were more common among patients with a burdened family history of M [22].…”

Section: Gene Nos3mentioning

confidence: 80%

“…- [10,14,18] -* [14,18] - [24,28] rs2070744 + [17,19,21] - [12,15,18,22] -* [15,18] + [35] - [30][31][32][33][34] +* [30,32] -* [31] rs207468799 - [18] -* [18] rs3918226 ± [10] - [12,15,17,18] -* [15,18] + [23,36,37] - [24,28] rs743506 + [12,15] - [18] +* [12] -* [15,18] rs7830 + [30] +* [30] VNTR 4 a/b - [12,15,16] -* [15] + [33,34] - [31,32,…”

Section: Discussionmentioning

confidence: 99%

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

et al. 2021

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Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype.

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“…In hemorrhoids, NOS, an enzyme that synthesizes nitric oxide from L-arginine, was reported to increase remarkably12. García-Martín et al 13 reported that the eNOS level was higher in people with migraines and had a history of migraines in their families and that eNOS inhibitors could be used in the treatment. There are publications revealing that a low level of eNOS is related to coronary artery disease14,15, essential hypertension16, and multiple sclerosis17.…”

Section: Discussionmentioning

confidence: 99%

The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease

Gökçe

Durmuş

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY AIM The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases (NOS), in the pathophysiology of hemorrhoidal disease. METHODS This study included 54 patients with grades 3 and 4 internal hemorrhoidal disease and 54 patients without the disease who attended the General Surgery Clinic. NOx, eNOS, and ADMA levels were measured with the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. RESULTS The patients had higher NO and eNOS levels and lower ADMA levels than the control subjects (p<0.001). A significant highly positive correlation was found between NO and eNOS (p<0.001). Nevertheless, there was a highly negative correlation between ADMA and NO-eNOS(p<0.001, p<0.001). CONCLUSION This preliminary study reveals that higher NOx and eNOS activities and lower ADMA levels in the rectal mucosa are observed in patients with hemorrhoidal disease than in those with normal rectal tissue. The imbalance between endothelium-derived relaxing factors, such as NO and endogenous competitive inhibitor of NOS, ADMA, may cause hemorrhoidal disease. Our study proposes that hemorrhoids display apparent vascular dilatation and present with bleeding or swelling. ADMA is an effective NOS inhibitor and may be a promising therapeutic option for hemorrhoidal disease.

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Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine

Cited by 13 publications

References 46 publications

Is there a relationship between dietary sodium and potassium intake and clinical findings of a migraine headache?

Is there a relationship between dietary sodium and potassium intake and clinical findings of a migraine headache?

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease

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