Association Between Epilepsy and Erectile Dysfunction: Evidence from a Population‐Based Study

Keller, Joseph J.; Chen, Yi Kuang; Lin, Herng Ching

doi:10.1111/j.1743-6109.2012.02670.x

Cited by 23 publications

(13 citation statements)

References 26 publications

(43 reference statements)

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“…Ascertained by GRADEpro, the rates of events of SD on average were 59.1% and 19.5% for female PWE and healthy individuals, respectively; and 58.6% and 9.8% for male PWE and the healthy controls, respectively. These results were in line with the findings of some other pertinent trials failing to meet our pre-defined eligibility criteria [13,[28][29][30][31], which showed the suspicious association between epilepsy and SD. Sensitivity analyses suggested that the quantification of the risk for the SD in PWE remained prominently high in nearly all of the studies, indicating our findings were robust.…”

Section: Discussionsupporting

confidence: 90%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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A B S T R A C TPurpose: Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD. Methods: PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/ PROSPERO). Results: Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I 2 = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I 2 = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE. Conclusions: Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.

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Section: Discussionsupporting

confidence: 90%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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“…22,23 Several factors including disease related, medicine related or psychological factors contribute to this problem in patients with epilepsy. 23 In our study there were only two patients with epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Use of neuro-psychiatry medicines in patients with sexual dysfunction: a retrospective study

Mutha

Kulkarni

Beldar

et al. 2017

Int J Basic Clin Pharmacol

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Background: The objective of the study was to understand the usage of neuro-psychiatry medicines in patients presenting with symptoms of sexual dysfunction.Methods: Medical records of adult patients consulting in the clinic out patients with symptoms of sexual dysfunction were screened for prescriptions of neuropsychiatry medicines. Common neuropsychiatric co-morbidities and prevalence of usage of medicines used for treating neuro-psychiatric disorders was calculated.Results: A total of 628 patients with sexual disorders were included of which 57 (9.1%) had received at least one neuro-psychiatry medicine at the time of presentation. Three most common sexual problems were unconsummated marriage 16 (28.1%), psychogenic ED 14 (24.6%) and organic erectile dysfunction 8 (14.0%). A total of erectile dysfunction 46 (7.3%) patients had psychiatric comorbidity. Five most common neuropsychiatric co-morbidities were anxiety 14 (30.4%), schizhophrenia 10 (21.7%), stress 7 (15.2%), depression 6 (13.0%) and epilepsy 2 (4.3%). The most commonly used neuro-psychiatry medicines were fluoxetine 15 (19.7%), risperidone 11 (14.5%), clonazepam 10 (13.2%), escitalopram 9 (11.8%), alprazolam 5 (6.6%), olanzapine 5 (6.6%) and gabapentin 4 (5.3%). Amisulpride was used in 3 (3.9%) patients whereas valproate, fluoxamine, diazepam and paroxetine were used in 2 (2.6%) patients each. Phenytoin, imipramine, carbamazepine, venlafaxine, haloperidol and sertarline were used in one patient each.Conclusions: Anxiety, schizophrenia and depression are the most common neuropsychiatric disorders in patients with sexual dysfunction. Many patients presenting with sexual dysfunction are already on neuropsychiatry medicines. Further studies are required to evaluate the association between neuropsychiatry medicines and sexual dysfunction in Indian patients.

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“…84.2%ii. 7.6%Erectile dysfunctionGTCSM (25)72%QuestionnaireNikoobakht et al (2007)PEM (16)32%Erectile dysfunctionPEM (418)25.8%Clinical interviewKeller et al (2012)IGEM (166)29.5% Reproductive i. Menstrual disordersii.…”

Section: Sexual Dysfunction In Epileptic Patientsmentioning

confidence: 99%

The relationship between epilepsy and sexual dysfunction: a review of the literature

2016

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Background and objectivesRegardless of the disease states that people suffer from, maintaining sexual function is an important indicator of quality of life. The objective of this review was to figure out the relationship between epilepsy, antiepileptic drugs (AEDs) and sexual dysfunction.ResultsIn various epidemiological and clinical studies, epilepsy has been correlated with a reduction in sexual function. This sexual dysfunction is not always detected in epileptic patients until systematic efforts are put in place, as part of the assessment and treatment process. Therefore, precise evaluations of the incidence of treatment related sexual dysfunction in epileptic patients is still lacking.ConclusionsThis literature review concluded that sexual function is influenced by the pathophysiology of epilepsy, as well as through the use of AEDs. To maximize quality of care in patients with epilepsy and those patients with other disease states who receive AEDs, it is important to address the status of the patient’s sexual function as part of the initial routine assessment and with any treatment related follow-up. Minimizing the effects of AED related sexual dysfunction can be achieved by raising awareness among patients, providing education and training for physicians regarding sexual dysfunction and obtaining a baseline sexual history from the patient so are important recommendations. In addition, systematic studies are needed to explore the risk and mechanism of such treatment related side effects on sexual function.

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Association Between Epilepsy and Erectile Dysfunction: Evidence from a Population‐Based Study

Cited by 23 publications

References 26 publications

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Use of neuro-psychiatry medicines in patients with sexual dysfunction: a retrospective study

The relationship between epilepsy and sexual dysfunction: a review of the literature

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