Association Between Epileptiform Discharges and the Sleep Cycle in 200 Epileptic Patients

Y, Lv; Wang, Zan; Ma, Dihui; Meng, Hongmei; Cui, Li

doi:10.3109/00207454.2012.746334

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…Markers of sleep fragmentation were higher than the control group, indicating an increase in the number of stage shifts, number of arousals and number of arousal indices in NREM and REM sleep (Table 2). Our data were consistent with previous reports on sleep fragmentation in patients with TLE [32,46,47].Yu-Dan et al (2013) previously showed that there was an association between epileptic form discharges and the sleep cycle in 200 patients with epilepsy [48]. This association was particularly higher in cases of temporal lobe epilepsy.…”

Section: Discussionsupporting

confidence: 93%

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Sleep Instability in Adults with NonRefractory Temporal Lobe Epilepsy

Trentin¹,

Costa²,

Lopes³

2017

SM J Sleep Disord

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The aim of this study was to analyze sleep instability using Cyclic Alternating Pattern (CAP) during NREM sleep in patients with non-refractory Temporal Lobe Epilepsy (TLE) compared to control subjects. Material and Methods:Our sample comprised 13 patients who underwent a neuroimaging examination and were diagnosed with non-refractory TLE, and 13 normal subjects. The sleep parameters and CAP analyses were assessed according to international criteria. We used the Mann-Whitney U-test with a significance level of 5%. Results:The age of our subjects were similar between patients and the control group (33.8 ± 8.5 y.o. vs 26.1 ± 9.2 y.o., respectively), and all of them showed normal sleep efficiency. Patients with non-refractory TLE showed an increase in the CAP rate and longer CAP time compared to the control group (p < 0.001). We found a higher arousal index during NREM sleep compared to normal controls (10.2 ± 2.9 versus 6.3 ± 1.7; p = 0.001, respectively). However, the arousal index during REM sleep was similar in both groups (p=0.075). A subgroup analysis performed on both genders showed no significant differences. Conclusion:Patients with non-refractory TLE showed an increased in CAP rate and arousal index compared to normal control subjects. Sleep instability might be associated with epilepsy itself and may reflect the relationship between the epileptic foci and systems responsible for sleep maintenance and stability. CAP may serve as a useful marker of endogenous circadian rhythms in mild disorders. Further studies are required to elucidate the role of sleep instability in TLE.

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Section: Discussionsupporting

confidence: 93%

“…This association was particularly higher in cases of temporal lobe epilepsy. In addition, these patients demonstrated longer mean sleep time during lighter sleep stages [48]. This data might explain the cognitive dysfunction and daytime symptoms observed in some patient cases, even though the seizures were under control.…”

Section: Discussionmentioning

confidence: 74%

Sleep Instability in Adults with NonRefractory Temporal Lobe Epilepsy

Trentin¹,

Costa²,

Lopes³

2017

SM J Sleep Disord

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“…First identified in the 1930s, IEDs are regarded as a hallmark of epilepsy and while researchers remain uncertain as to their significance they are widely believed to reflect cortical hyperexcitability. The frequency of IEDs increases after sleep deprivation and is higher during NREM sleep which also has the highest tendency for seizures during the sleep cycle [305][306][307][308][309][310][311]. Such heightened susceptibility, once again, is attributable to diminished amplitude of the electromagnetic wave function.…”

Section: Threshold and Susceptibilitymentioning

confidence: 99%

Energy Dynamics in Seizure Disorder: Reexamining the Sacred Disease

Thorp,

Northrup

et al. 2024

G Med Sci

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In this paper we explore the dynamic basis of epilepsy, the sacred disease, and show, surprisingly, that in all cases its manifest signs and symptoms correspond to the four-tier vertical framework –material, efficient, formal and final causes – advanced by Aristotle a half-century after the Hippocratic works surfaced. Specifically, impaired energy dynamics during the seizure state transiently disrupt the couplement between the material and formal causal layers of the body precipitating the behavioral alterations that define epilepsy.

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“…Sleep spindles are an electrographic signature of sleep that correlate in frequency with interictal spike-wave discharges ( 25 ) and may be biomarkers of epilepsy in humans ( 26 ). They are relevant in both generalized ( 27 ) as well as focal epilepsy ( 28 ) and display altered morphology in many epilepsy patients ( 29 ). Sleep spindles are also subject to regulation by circadian rhythms ( 30 ).…”

Section: Time Of Day and Sleep/wake Effects On Seizures In Epilepsymentioning

confidence: 99%

The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy

Batterman

Gerstner

et al. 2020

Front. Neurol.

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Seizure patterns observed in patients with epilepsy suggest that circadian rhythms and sleep/wake mechanisms play some role in the disease. This review addresses key topics in the relationship between circadian rhythms and seizures in epilepsy. We present basic information on circadian biology, but focus on research studying the influence of both the time of day and the sleep/wake cycle as independent but related factors on the expression of seizures in epilepsy. We review studies investigating how seizures and epilepsy disrupt expression of core clock genes, and how disruption of clock mechanisms impacts seizures and the development of epilepsy. We focus on the overlap between mechanisms of circadian-associated changes in SCN neuronal excitability and mechanisms of epileptogenesis as a means of identifying key pathways and molecules that could represent new targets or strategies for epilepsy therapy. Finally, we review the concept of chronotherapy and provide a perspective regarding its application to patients with epilepsy based on their individual characteristics (i.e., being a "morning person" or a "night owl"). We conclude that better understanding of the relationship between circadian rhythms, neuronal excitability, and seizures will allow both the identification of new therapeutic targets for treating epilepsy as well as more effective treatment regimens using currently available pharmacological and non-pharmacological strategies.

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Association Between Epileptiform Discharges and the Sleep Cycle in 200 Epileptic Patients

Abstract: Combination of long-term video EEG with polysomnography is a useful method to analyze associations between EDs and the sleep-wake cycle. This strategy can also help identify the nature of sleep disorders in epileptic patients, which may improve the treatment efficacy.

Cited by 6 publications

References 18 publications

Sleep Instability in Adults with NonRefractory Temporal Lobe Epilepsy

Sleep Instability in Adults with NonRefractory Temporal Lobe Epilepsy

Energy Dynamics in Seizure Disorder: Reexamining the Sacred Disease

The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy

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