Association between epithelial-mesenchymal transition markers, proliferative index, and oral epithelial dysplasia: an immunohistochemical study

Miguel, Andressa Fernanda Paza; Poletto, André Goulart; Embaló, Bubacar; Rivero, Elena Riet Correa

doi:10.1016/j.oooo.2023.03.005

Cited by 1 publication

(1 citation statement)

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“…As of today, despite recent modifications discarding the use of the term “carcinoma in-situ” in the last World Health Organization classification of oral epithelial dysplasia, the American Joint Committee on Cancer (AJCC) Cancer Staging Manual prevails as a pivotal clinical manual that still uses “carcinoma in- situ” instead of “severe epithelial dysplasia” to characterize the earliest form of OSCC in their definition of TNM grading for the oral cavity. Moreover, we recognize that conventional two-dimensional slide evaluation may overlook critical molecular processes related to epithelial-mesenchymal interactions ( 21 , 22 ). Correspondingly, the implications of using one term over the other remain misunderstood in oral, otorhinolaryngology and head and neck surgery medical practices, as these two diagnoses have been previously proposed as equivalent by the World Health Organization.…”

Section: Discussionmentioning

confidence: 99%

Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study

Saldivia-Siracusa,

Araújo,

Arboleda

et al. 2024

Med Oral

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Background To describe demographic and clinicopathological aspects of a South-American cohort of incipient oral squamous cell carcinoma patients. Material and Methods A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South-American institutions. Results One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in-situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), ≥ 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red. Conclusions To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians’ inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies. Key words: Mouth neoplasm, diagnosis, oral squamous cell carcinoma, microinvasive, carcinoma in-situ.

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Section: Discussionmentioning

confidence: 99%