Association between Epstein-Barr virus (EBV) and cervical carcinoma: A meta-analysis

Lima, Marcos Antônio Pereira de; Neto, Pedro Januário Nascimento; Lima, Lívia Peixoto Moreira; Júnior, Jucier Gonçalves; Teixeira, Antonio Gilvan; Teodoro, Ilara Parente Pinheiro; Facundo, Heberty T.; Silva, Cláudio Gleidiston Lima da; Lima, Marcos Venício Alves

doi:10.1016/j.ygyno.2017.10.005

Cited by 56 publications

(88 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27,28 Although cellular localization of EBV remains contested, previous reports are in agreement that EBV can infect cervical tissues and potentially influence the risk of progression to high-grade cervical lesions and cervical cancer. 15,16,29,30 Our present findings confirm previous studies including a metaanalysis which found that EBV infection was significantly and positively associated with lesion grade in cervical epithelia and was more prevalent in malignant lesions. 14,18,24,31 This meta-analysis also demonstrated an association with EBV proteins and integration of HrHPV DNA, though further studies were suggested to be performed before a firm link between EBV and cervical carcinoma can be established.…”

Section: Resultssupporting

confidence: 90%

“…Our present findings confirm previous studies including a meta‐analysis which found that EBV infection was significantly and positively associated with lesion grade in cervical epithelia and was more prevalent in malignant lesions . This meta‐analysis also demonstrated an association with EBV proteins and integration of HrHPV DNA, though further studies were suggested to be performed before a firm link between EBV and cervical carcinoma can be established.…”

Section: Discussionsupporting

confidence: 91%

“…However, some studies have shown that EBV does not reside in the cervical epithelium but rather within infiltrating lymphoid cells adjacent to the tumor epithelium, potentially influencing the microenvironment . Although cellular localization of EBV remains contested, previous reports are in agreement that EBV can infect cervical tissues and potentially influence the risk of progression to high‐grade cervical lesions and cervical cancer …”

Section: Discussionmentioning

confidence: 99%

“…Positivity to HrHPV types (including HPV 16,18,31,33,35,39,45,51,52, 56, 59, 66, and 68) was determined using Aptima HPV messenger RNA Detection Assay according to the manufacturer's protocol (Hologic). Analyses were conducted blinded of EBV, CMV, and cytology results at Hologic Corporation testing laboratory (San Diego, CA).…”

Section: Hpv Detectionmentioning

confidence: 99%

See 3 more Smart Citations

Epstein‐Barr virus, but not human cytomegalovirus, is associated with a high‐grade human papillomavirus–associated cervical lesions among women in North Carolina

Kienka

Varga

Caves

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Statement of the problem Human papillomavirus (HPV) infection is known to contribute to cervical carcinogenesis, yet other cofactors that may contribute to oncogenesis are poorly understood. Herein, we examine whether the Epstein‐Barr virus (EBV) and human cytomegalovirus (CMV), two oncomodulatory viruses, are associated with HPV‐mediated cervical neoplastic progression. Methods Sixty patient cervical brush samples from a study of North Carolina women were obtained. HPV RNA positivity was determined by Aptima testing (Hologic Corporation, Marlborough, MA). The level of viral transcripts for EBV and CMV was quantified (reverse transcription polymerase chain reaction analysis), and the coinfection status with HPV was then compared with the patient's cervical cytology grade. Results Over one‐third (38.3%) of the study population was CMV positive, whereas 43.3% was EBV positive. When sample data were stratified by the cytology grade, 36.5% (19/52) of normal patients, 75% (3/4) of low‐grade squamous intraepithelial lesions (LSIL), and 100% (4/4) of patients with high‐grade SIL (HSIL) were EBV positive. Conversely, 35.2% (18/52) of normal patients, 25% (1/4) of patients with LSIL, and 50% (2/4) of patients with HSIL were CMV positive. When examining only HPV positive–associated HSIL, 100% (4/4) were positive for both HPV and EBV detection. This suggests that co‐viral detection with HPV and EBV is associated with more advanced HSIL cervical lesions, while CMV displayed no clear association with a higher grade of cervical cytology. Conclusions Co‐viral detection with EBV may increase the oncogenicity and/or serve as a viral marker of progression to HPV‐associated high‐grade cervical dysplasia.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Hpv Detectionmentioning

confidence: 99%

See 2 more Smart Citations

Epstein‐Barr virus, but not human cytomegalovirus, is associated with a high‐grade human papillomavirus–associated cervical lesions among women in North Carolina

Kienka

Varga

Caves

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Detection of HR-HPV DNA was based on a sensitive PCR, whereas a less sensitive sandwich ELISA assay was used to detect the E7 protein. Co-infection with other oncogenic viruses is considered a contributing factor in cervical cancer [24]. Drop and colleagues examined the co-presence of HPV (28 different genotypes), BKPyV, and Epstein-Barr virus (EBV) DNA in oral, oropharyngeal, and laryngeal squamous cell carcinomas in a Polish cohort ( n = 146) [21].…”

mentioning

confidence: 99%