“…The association between D5D and D6D activities and metabolic syndrome may be explained by their role in the management of insulin sensitivity and insulin resistance , as well as inflammatory markers . A direct association between higher activities of D6D and insulin resistance , BMI , fasting blood glucose , waist circumference , liver fat accumulation and triglyceride concentrations has been observed. By contrast, a higher activity of D5D was inversely associated with insulin resistance , BMI , blood pressure , waist circumference , liver fat accumulation and triglyceride concentrations , as well as with higher insulin sensitivity .…”