Association between Exposure to Environmental Tobacco Smoke and Biomarkers of Oxidative Stress Among Patients Hospitalised with Acute Myocardial Infarction

Abstract

ObjectiveTo determine whether exposure to environmental tobacco smoke was associated with oxidative stress among patients hospitalised for acute myocardial infarction.DesignAn existing cohort study of 1,261 patients hospitalised for acute myocardial infarction.SettingNine acute hospitals in Scotland.ParticipantsSixty never smokers who had been exposed to environmental tobacco smoke (admission serum cotinine ≥3.0 ng/mL) were compared with 60 never smokers who had not (admission serum cotinine ≤0.1 ng/mL).InterventionNone.Main outcome measuresThree biomarkers of oxidative stress (protein carbonyl, malondialdehyde (MDA) and oxidised low-density lipoprotein (ox-LDL)) were measured on admission blood samples and adjusted for potential confounders.ResultsAfter adjusting for baseline differences in age, sex and socioeconomic status, exposure to environmental tobacco smoke was associated with serum concentrations of both protein carbonyl (beta coefficient 7.96, 95% CI 0.76, 15.17, p = 0.031) and MDA (beta coefficient 10.57, 95% CI 4.32, 16.81, p = 0.001) but not ox-LDL (beta coefficient 2.14, 95% CI −8.94, 13.21, p = 0.703).ConclusionsExposure to environmental tobacco smoke was associated with increased oxidative stress. Further studies are requires to explore the role of oxidative stress in the association between environmental tobacco smoke and myocardial infarction.

The Effects of Smoking on IgE, Oxidative Stress and Haemoglobin Concentration

“…According to the result of this study, the effect of smoke among passive smokers to elevate Malondialdehyde is clearly observed because of the concentration of Malondialdehyde in the sera of passive smokers higher than non-smokers. Our results were similar to that of Megson et al, (2013); Rodgman and Perfetti, (2013) ;Kalaiselvi, (2016).…”

Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease

“…Therefore, exposure to ETS leads to a risk of cardiovascular events associated with active smoking. The study of Megson et al [17] proved that patients with acute myocardial infarction (AMI) who were exposed to ETS and admitted to the intensive care unit had increased oxidative stress, as demonstrated by two independent plasma biomarkers (malondialdehyde and protein carbonyl). By this way they proved the role of ETS in the development of atherosclerosis and the occurrence of AMI.…”

Environmental Tobacco Smoke and Atrial Fibrillation

“…ETS exposure has been associated with increased levels of inflammatory biomarkers and decreased heart rate variability, a measure of cardiac autonomic dysfunction (5-8). Alterations in the inflammatory response have been linked to AF development (15).…”

“…A similar law in Arizona was associated with nearly 13% fewer admissions for MI, 33% fewer admissions for unstable angina, and 14% fewer admissions for stroke (24). Increased levels of inflammatory markers and oxidative stress have been observed in persons with ETS exposure and these abnormalities possibly lead to an increased risk for cardiovascular disease development (5). These data provide additional evidence of the harmful effects of ETS exposure and the substantial health benefits from comprehensive bans on smoking.…”

“…Other reports have implicated ETS exposure with an increased risk of cardiovascular-related mortality (4). Increased levels of inflammatory markers and oxidative stress have been observed in persons exposed to ETS and potentially contribute to the increased risk of adverse cardiovascular events in this population (5). …”