Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma

Dan, Jeong; Li, Shengjin; Ho, In

doi:10.1002/hed.21507

Cited by 28 publications

(51 citation statements)

References 56 publications

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“…Therefore, we can postulate that the elevated expression of COX2 may have an important role in predicting the clinical outcome in oral cancer, and these many essential processes in carcinogenesis make COX2 an attractive therapeutic target. In consistence with our results, Cha et al detected the expression of COX2 via immunohistochemistry analyses of 103 OSCC samples indicating that the upregulated COX2 expression in oral cell lines may be a possible prognostic parameter for reduced overall survival [19]. Similarly, Sakurai et al also found that the expression of COX2 was related to lymph node metastasis and cell proliferative activity, as well as overall 5-year survival rate in oral carcinoma, and thereby this enzyme may be valuable in diagnostic and prognostic indices in oral carcinoma [11].…”

Section: Discussionsupporting

confidence: 90%

“…On the contrary, selective COX2 inhibitors suppress growth of cells by inducing G0/G1, cell-cycle arrest, and cellular proliferation; thus apoptosis could have a reversed effect on the development and progression of cancers [17]. Similar to the results of the present study on the expression of COX2 and the pathogenesis of human tumors, previous reports have suggested a correlation between the expression of COX2 and the occurrence of oral cancer [18, 19]. In general, COX2 may initially stimulate angiogenesis and vascular endothelial cell growth that are essential in tumor growth and spread, promoting the production of prostaglandin E2 and cyclin-dependent kinase inhibitor P21 expression [20].…”

Section: Introductionsupporting

confidence: 85%

“…Another 2 studies were also excluded due to lack of data integrity (Figure 1). Eventually, 12 clinical cohort studies with a total of 979 oral cancer patients met our inclusion criteria for quantitative data analysis [8, 11, 18, 19, 21–23, 27–31]. There were 5 independent analyses focused on the prognosis of oral cancer, some of which were divided into two groups, including COX2-positive group ( n = 157) and COX2-negative group ( n = 254).…”

Section: Resultsmentioning

confidence: 99%

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Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer: A Meta-Analysis

Wang

Liu

et al. 2014

BioMed Research International

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Background. The prognostic significance of COX2 for survival of patients with oral cancer remains controversial. Thus, the meta-analysis was performed in order to identify COX2 expression impact on prognosis of oral cancer. Method. Relevant literatures were searched using the following electronic databases without any language restrictions: Web of Science, the Cochrane Library Database, PubMed, EMBASE, CINAHL, and CBM. Version 12.0 STATA software (Stata Corporation, College Station, Texas, USA) was used for the current meta-analysis. Odds ratios (ORs) and hazard ratios (HRs) with their corresponding 95% confidence interval (95% CI) were also calculated to clarify the correlation between COX2 expression and prognosis of oral cancer. Results. Final analysis of 979 oral cancer patients from 12 clinical cohort studies was performed. The meta-analysis results show that COX2 expression in cancer tissues was significantly higher than those in normal and benign tissues (all P < 0.05). Combined HR of COX2 suggests that positive COX2 expression has a shorter overall survival (OS) than those of negative COX2 expression (P < 0.05). Conclusion. The meta-analysis study shows that elevated COX2 expression may be associated with the pathogenesis of oral cancer and with a worse prognosis in oral cancer patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

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Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer: A Meta-Analysis

Wang

Liu

et al. 2014

BioMed Research International

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“…Thus, cytoplasmic HuR expression can be useful as an independent prognostic parameter for the reduced overall survival of oral cancer patients. 25) Our data showed that HuR knockdown substantially lowered MMP-9 level in YD-10B cells with or without PMA stimulation, and KPS-A suppressed the cytoplasmic level of HuR peaked at 6 h after PMA exposure. These results suggest that KPS-A may reduce MMP-9 expression by blocking its HuR-mediated mRNA stabilization at the post-transcriptional level.…”

Section: Discussionsupporting

confidence: 51%

Kalopanaxsaponin A Inhibits the Invasion of Human Oral Squamous Cell Carcinoma by Reducing Metalloproteinase-9 mRNA Stability and Protein Trafficking

Hwang

Park

Chung

2012

Biological & Pharmaceutical Bulletin

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Key words Kalopanaxsaponin-A; oral cancer; anti-invasive effect; metalloproteinase-9; HuR; Ras-associated binding 1AOral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region, and it is the sixth most common cancer worldwide. In high-risk countries such as Sri Lanka, India, Pakistan, and Bangladesh, oral cancer may contribute up to 25% of all new cases of cancer, and in most countries, the five-year survival rates for cancers of the tongue, oral cavity and oropharynx are around 50%. 1)OSCC is characterized by a high degree of local invasiveness and a high rate of metastasis to the cervical lymph nodes. 2)Despite multidisciplinary treatment with surgery, chemotherapy and radiation, the overall survival rate has not improved significantly in patients with oral cancer. In addition, many patients who are successfully treated for oral cancer have to cope with devastating consequences in their appearance and function, including eating, drinking, swallowing and speaking.1) Consequently, controlling the invasiveness and metastasis of oral cancer represents an important therapeutic goal.OSCC progression is frequently associated with the acquisition of a more invasive phenotype and with proteinasedependent extracellular matrix (ECM) degradation.2) Invasive OSCC cells secrete matrix metalloproteinases (MMPs), which are mainly responsible for the degradation of environmental barriers such as ECM and the basement membrane. 3,4)

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“…Four studies reported no site-specific HNC [24, 54–57] and others recorded site-specific HNC. There were 7, 6 and 9 studies focused on oral cancer (OC) [22, 25, 27, 37–40], laryngeal cancer (LC) [41–46] and nasopharyngeal cancer (NPC) [23, 26, 47–53], respectively. The total number of patients was 2430, ranging from 20 to 301 cases per study.…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

et al. 2016

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Several studies have assessed the clinicopathological and prognostic value of cyclooxygenase-2 (COX-2) expression in patients with head and neck cancer (HNC), but their results remain controversial. To address this issue, a meta-analysis was carried out. A total of 29 studies involving 2430 patients were subjected to final analysis. Our results indicated that COX-2 expression was not statistically associated with advanced tumor stage (OR, 1.23; 95% CI, 0.98–1.55) but correlated with high risk of lymph node metastasis (OR, 1.28; 95% CI, 1.03–1.60) and advanced TNM stage (OR, 1.33; 95% CI, 1.06–1.66). Moreover, COX-2 expression had significant effect on poor OS (HR, 1.93; 95% CI, 1.29–2.90), RFS (HR, 2.02; 95% CI, 1.00–4.08) and DFS (HR, 5.14; 95% CI, 2.84–9.31). The results of subgroup analyses revealed that COX-2 expression was related with high possibility of lymph node metastasis in oral cancer (OR, 1.49; 95% CI, 1.01–2.20) and advanced TNM stage in oral cancer (OR, 1.58; 95% CI, 1.05–2.37) and no site-specific HNC (OR, 1.64; 95% CI, 1.02–2.62). However, subgroup analyses only showed a tendency without statistically significant association between COX-2 expression and survival. Significant heterogeneity was not found when analyzing clinicopathological data, but it appeared when considering survival data. No publication bias was detected in this study. This meta-analysis suggested that COX-2 expression could act as a prognostic factor for patients with HNC.

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Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma

Abstract: Our results indicate that the cytoplasmic expression of HuR is associated with COX-2 expression in OSCCs and HuR can regulate COX-2 expression in oral cancer cell lines.

Cited by 28 publications

References 56 publications

Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer: A Meta-Analysis

Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer: A Meta-Analysis

Kalopanaxsaponin A Inhibits the Invasion of Human Oral Squamous Cell Carcinoma by Reducing Metalloproteinase-9 mRNA Stability and Protein Trafficking

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

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