Association between fatty liver index and risk of end-stage renal disease stratified by kidney function in patients with type 2 diabetes: A nationwide population-based study

Chung, Gyung Ho; Han, Kyungdo; Lee, Kyu-Na; Bae, Jung Ho; Yang, Sun Young; Choi, Seung Young; Yim, Jeong Yoon; Heo, Nam Ju

doi:10.1016/j.diabet.2023.101454

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…(2022) [61] longitudinal cohort study of 3,188 T2D patients with normal renal function followed for 8.3 ± 3.6 years. In NAFLD, advanced liver fibrosis was defined as a FIB-4 index ≥ 2.67 CKD was defined as an eGFR of < 60 L/min/1.73 m 2 for two consecutive times during follow-up visits Compared to the non-NAFLD controls, the NAFLD group did not have any higher risk of incident CKD, but among NAFLD patients, advanced liver fibrosis was associated with an increased risk of CKD Advanced hepatic fibrosis is a risk factor for incident CKD among NAFLD individuals with T2D Sun et al (2022) [62] Cross-sectional study comprising 13,915 participants to whom 1,734 additional individuals who had been followed annually for 5 years were added retrospectively CKD was defined as either kidney damage (i.e., pathologic abnormalities or markers of damage, including abnormalities in blood or urine tests or imaging results) or eGFR < 60 mL/min/ Utilizing population-based observational data from the KNHIS, a cohort of 1,900,598 T2D patients were followed for a median period of 7.2 years CKD was defined as eGFR < 60 mL/min/…”

Section: Pathomechanismsmentioning

confidence: 99%

Association of NAFLD/NASH, and MAFLD/MASLD with chronic kidney disease: an updated narrative review

Lonardo

2024

Metab Target Organ Damage

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Chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) account for substantial financial burden worldwide. These alarming features call for enhanced efforts to prevent and manage the development and progression of CKD. Accumulating evidence supporting a causal role of NAFLD/MAFLD/MASLD-in CKD opens new horizons to achieve this aim. Recent epidemiological studies and meta-analyses exploring the association of NAFLD/MAFLD/MASLD with CKD and the characteristics of NAFLD/MAFLD/MASLD associated with the odds of incident CKD are discussed. The involved pathomechanisms, including the common soil hypothesis, genetics, gut dysbiosis, and portal hypertension, are examined in detail. Finally, lifestyle changes (diet and physical exercise), direct manipulation of gut microbiota, and drug approaches involving statins, renin-angiotensin-aldosterone system inhibitors, GLP-1 Receptor Agonists, Sodium-glucose cotransporter-2, pemafibrate, and vonafexor are examined within the context of prevention and management of CKD among those with NAFLD/MAFLD/MASLD. The evolving NAFLD/MAFLD/MASLD nomenclature may generate confusion among practicing clinicians and investigators. However, comparative studies investigating the pros and contra of different nomenclatures may identify the most useful definitions among NAFLD/MAFLD/MASLD and strategies to identify, prevent, and halt the onset and progression of CKD.

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Section: Pathomechanismsmentioning

confidence: 99%

Association of NAFLD/NASH, and MAFLD/MASLD with chronic kidney disease: an updated narrative review

Lonardo

2024

Metab Target Organ Damage

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Fatty liver index and somatic composition in subjects receiving medical health checkup

Ushiro,

Matsui,

Fukuda

et al. 2024

Hepatology Research

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AimsTo elucidate the relationship between fatty liver index (FLI) and somatic composition among health checkup recipients (4533 men and 4877 women).MethodsFat (F) index, fat‐free (FF) index, and fat mass to fat‐free mass (F‐FF) ratio was measured by bioimpedance analysis. Skeletal muscle mass (SMM) loss was defined as FF index <18 kg/m2 in men and FF index <15 kg/m2 in women. The impact of FLI on the somatic composition (i.e., F index, FF index, and F‐FF ratio) was retrospectively investigated.ResultsThe median age in men and women was 54 and 52 years (p < 0.0001). The median body mass index in men and women was 23.4 and 21.1 kg/m2 (p < 0.0001). The prevalence of fatty liver on ultrasonography was 52.5% in men and 22.1% in women. The median FLI in men and women was 25.1 and 6.9 (p < 0.0001). Fatty liver index correlated significantly with F index (r > 0.5 in all analyses). In all analyses, the decreased SMM group had significantly lower FLI than the nondecreased SMM group. In receiver operating characteristic (ROC) curve analysis for the SMM decrease, in both genders, area under the ROCs of FLI were all over 0.80 (optimal cut‐off point: 19.7 in men and 8.4 in women). The FLI correlated significantly with F‐FF ratio (r > 0.5 in all analyses).ConclusionThe FLI can be a good indicator of not only fat mass but also FF mass and body composition balance in health checkup subjects. The FLI may not be just a marker of hepatic steatosis.

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Association between composite dietary antioxidant index and fatty liver index among US adults

Zheng,

Li,

et al. 2024

Front. Nutr.

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BackgroundThe potential beneficial health effects of dietary antioxidants have been reported. However, the association of a composite dietary antioxidant index (CDAI) with fatty liver index (FLI) remains unclear. This study aims to assess whether CDAI (including its components) is associated with FLI among US adults.MethodsThis population-based cross-sectional study used data on US adults from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 cycles. Weighted generalized linear regression models were used to analyze the association between CDAI (including vitamin A, C, E, zinc, selenium, and carotenoids) and FLI, which was calculated by using body mass index (BMI), waist circumference and levels of γ-glutamyl transferase and triglycerides.ResultsWeighted generalized linear regression models showed an inverse association between CDAI and FLI in the total population (β, −0.40; 95% CI, −0.59, −0.21), in women (β, −0.56; 95% CI, −0.94, −0.18), and in men (β, −0.32; 95% CI, −0.54, −0.10) after adjusting for various confounders. The restricted cubic splines showed the negative linear dose–response associations between CDAI and FLI (all P non_linear >0.05). The dietary selenium intake in women has an inverse U-shaped relationship with FLI, with an inflection point value of 110 μg. In model 3, intake of dietary antioxidants Vitamins A, C, E, and carotenoids were significantly negatively associated with FLI in female but only were vitamins A and E negatively associated with FLI in male. In subgroup analysis, CDAI showed a significantly negative relation to FLI among those aged 60 years or older (β, −0.57; 95% CI, −0.81, −0.33), among those who engaged in active physical activity (β, −0.46; 95% CI, −0.63, −0.29), among those without metabolic syndrome (β, −0.43; 95% CI, −0.62, −0.24), and those without hyperuricemia (β, −0.43; 95% CI, −0.60, −0.26). Additionally, CDAI was significantly negatively associated with male FLI, regardless of whether they had diabetes or not.ConclusionIn conclusion, our results indicate that higher CDAI may be associated with a lower FLI.

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Association between fatty liver index and risk of end-stage renal disease stratified by kidney function in patients with type 2 diabetes: A nationwide population-based study

Cited by 3 publications

References 54 publications

Association of NAFLD/NASH, and MAFLD/MASLD with chronic kidney disease: an updated narrative review

Association of NAFLD/NASH, and MAFLD/MASLD with chronic kidney disease: an updated narrative review

Fatty liver index and somatic composition in subjects receiving medical health checkup

Association between composite dietary antioxidant index and fatty liver index among US adults

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