Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease among a Cognitively Healthy Population-based Cohort
Abstract:Background: Epidemiological evidence suggests air pollution adversely affects cognition and increases the risk of Alzheimer′s disease (AD), but little is known about the biological effects of fine particulate matter (PM2.5) on early predictors of future disease risk. Objectives: We investigated the association between 1, 3, and 5-year exposure to ambient and traffic-related PM2.5and cerebrospinal fluid (CSF) biomarkers of AD. Methods: We conducted a cross-sectional analysis using data from 1,113 cognitively he… Show more
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