Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Bazzi, Mohammad D.; Nasr, Fahd A.; Alanazi, Mohammad; Alamri, Abdullah; Turjoman, Abdullah Arif; Moustafa, Amr Soliman; Alfadda, Assim A.; Pathan, Akbar Ali Khan; Parine, Narasimha Reddy

doi:10.4238/2014.december.4.14

Cited by 36 publications

(20 citation statements)

References 26 publications

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“…There was no significant association between FTO SNP and the risk of diabetes as an independent variable. Another study on the Saudi population in the middle region was conducted on the same SNP showed no correlation with T2DM, similar to the current study [22]. However, contrary to our results, two Iraqi studies revealed a significant association of FTO rs9939609 variant with the risk of T2DM in obese patients [23,24].…”

Section: Discussionsupporting

confidence: 73%

“…These findings were followed by a series of studies that genotyped FTO rs9939609 in several populations with different ethnic backgrounds [18][19][20][21]. Previous association studies on Arab populations about the contribution of FTO rs9939609 to the risk of T2DM, one in the middle Saudi population [22] and two among the Iraqi population [23,24], showed divergent results. The mechanistic basis for the genetic association between FTO and obesity appears to be due to the disruption of AT-Rich Interaction Domain 5B repressor through the causal variants of FTO.…”

Section: Introductionmentioning

confidence: 99%

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The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

Bakhashab

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et al. 2020

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Type 2 diabetes mellitus (T2DM) is a common polygenic disease with associated comorbidities. Obesity is a major risk factor for the development of T2DM. The aim of this study is to determine the allele and genotype frequency of peroxisome proliferator-activated receptor-γ (PPARγ) rs1801282, fat mass and obesity-associated protein (FTO) rs9939609, and melanocortin 4 receptor (MC4R) rs2229616 polymorphisms and their association with risk of T2DM in the western Saudi population as mediators of adiposity phenotypes. In a cross-sectional prospective study, genomic DNA from control and T2DM patients were isolated and genotyped for these single-nucleotide polymorphisms. There was a significant association of the MC4R rs2229616 variant with T2DM, but no association with T2DM was detected with PPARγ rs1801282 or FTO rs9939609. The combination of C/C for PPARγ rs1801282, A/A for FTO rs9939609, and C/C for MC4R rs2229616 increased the risk of T2DM by 1.82. The A/T genotype for FTO rs9939609 was predicted to decrease the risk of T2DM when combined with C/C for PPARγ rs1801282 and C/C for MC4R rs2229616 or C/C for PPARγ rs1801282 and C/T MC4R rs2229616. In conclusion, our study showed the risk of the assessed variants for the development of T2DM in the Saudi population.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

Bakhashab

Filimban

Altall

et al. 2020

Genes

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“…A recent study by Kamura et al [25] suggested that the association between FTO variants and T2D is mediated through the lifetime maximum BMI at the time of or before diagnosis of T2D. Nevertheless, our lack of association with the T2D risk has also been reported in populations of similar genetic background to the Kuwaiti population [26, 27]. It is apparent that ethnicity plays a role in FTO rs9939609 and T2D risk among different populations, possibly under the influence of other T2D susceptibility factors of stronger effect.…”

Section: Discussioncontrasting

confidence: 49%

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

et al. 2018

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Objective: To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide. Subjects and Methods: Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait’s Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics. Results: The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16–2.26; p = 0.023). In concordance, the categorical BMI (normal vs. overweight/obese) also showed a significant association between the A allele and overweight/obesity (OR = 1.47; 95% CI = 1.01–2.12; p = 0.041). However, no association between the FTO variant was observed with cardiometabolic traits. Conclusion: We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. Our findings encourage further investigation of genetic variants to elucidate the mechanisms involved in the development of obesity in such an obesogenic population.

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“…In agreement to our results, a number of other studies also did not nd any association of this variant with diabetes and related metabolic disturbances. [74][75][76] Our study also reports no association of this variant with blood pressure in our population. In agreement to our study, Timpson and colleagues did not nd any association of this variant with blood pressure.…”

Section: Discussionsupporting

confidence: 43%

MC4R variant rs17782313 and manifestation of obese phenotype in Pakistani females

2018

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Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Cited by 36 publications

References 26 publications

The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

MC4R variant rs17782313 and manifestation of obese phenotype in Pakistani females

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