Association between gastric myoelectric activity disturbances and dyspeptic symptoms in gastrointestinal cancer patients

Zygulska, Aneta L.; Furgała, Agata; Krzemieniecki, Krzysztof; Wlodarczyk, Beata; Thor, Piotr

doi:10.1016/j.advms.2018.08.004

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Our previous study investigated an association between gastric myoelectric activity disturbances in response to meal showed in colon, rectal and gastric cancer patients similarly lower percentages of normogastria time, lower percentages of ACSWC and higher values of DP than the controls in a fasted state. In response to meal no improvement in the percentage of normogastria time, DP, DF and ACSWC was observed in patients with GI malignancies (13). The response to meal was disturbed in gastrointestinal malignancies, but the analysis effect of the WLT better presented dysfunction of neurological regulation GI motility.…”

Section: Tab 2 Hemodynamic Parameters In Patients With Various Gastrointestinal Malignancies and Healthy Controls Determined In A Fasted mentioning

confidence: 83%

“…While EGG cannot be used to diagnose a specifi c disease, it provides information about upper gastrointestinal tract motility in many pathological conditions, such as gastroparesis in diabetic neuropathy, gastroesophageal refl ux disease, cyclic vomiting in children and functional dyspepsia (11,12). Abnormal results of EGG correlated with the severity of symptoms in patients with unresectable gastric cancer (13). Our previous studies showed that colorectal and gastric cancers affect gastric myoelectric activity, decreasing normogastria and slow wave coupling.…”

Section: Introductionmentioning

confidence: 99%

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The effect of visceral reception activation (water load test) on autonomic activity and gastric myoelectric activity in gastrointestinal malignancies

Zygulska¹,

Furgała²,

Krzemieniecki³

et al. 2021

BLL

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The aim of this study was to analyze the effect of water load test (WLT) on heart rate variability (HRV), blood pressure variability (BPV), hemodynamic parameters and gastric myoelectric activity in gastrointestinal (GI) cancer patients. BACKGROUND: WLT activates gastrointestinal mechanoreception and osmoreception, and hence, can indirectly modulate autonomic activity. METHODS: Eighty patients (mean age 61.2 years) were enrolled, along with the group of healthy controls. HRV, BPV and electrogastrography (EGG) were recorded at rest (in a fasted state) and after water uptake at 100 ml/min. RESULTS: WLT contributed to an increase in the percentages of normogastria time, from 37.3 % to 50.0 % (p=0.02) and from 42.3 % to 47.7 % (p=0.01), respectively in colon and rectal cancer. Cancer patients presented lower values of HRV indices determined on linear analysis at rest and after WLT. CONCLUSIONS: A slight predominance of the sympathetic component was observed in response to WLT, which was refl ected by changes in hemodynamic parameters. The response to WLT is a consequence of GI mechanoreception and osmoreception activation and resultant pressure reaction. This effect was disrupted by the neoplastic process within the GI tract, especially in gastric and colon malignancies, but not in rectal cancer (Tab. 2, Fig. 3, Ref. 40).

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Section: Tab 2 Hemodynamic Parameters In Patients With Various Gastrointestinal Malignancies and Healthy Controls Determined In A Fasted mentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

The effect of visceral reception activation (water load test) on autonomic activity and gastric myoelectric activity in gastrointestinal malignancies

Zygulska¹,

Furgała²,

Krzemieniecki³

et al. 2021

BLL

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show abstract

“…EGG is a noninvasive method for the measurement of gastric myoelectrical activity that uses abdominal surface electrodes 34 . While direct techniques examined gastric motility (by measuring gastric emptying time) can only be used to determine the postprandial motor status, the EGG accurately determines indirectly gastric motor function in both the preprandial and postprandial states 34 , 35 . In published studies the positive predictive value of EGG for normal gastric emptying ranges from 65 to 100% (average 85%) and from 50 to 81% for predicting abnormal gastric emptying (average 65%) 13 , 36 .…”

Section: Discussionmentioning

confidence: 99%

Postprandial effect of gastrointestinal hormones and gastric activity in patients with irritable bowel syndrome

Furgała

Ciesielczyk

Przybylska-Feluś

et al. 2023

Sci Rep

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Altered gut regulation, including motor and secretory mechanisms, is characteristic of irritable bowel syndrome (IBS). The severity of postprandial symptoms in IBS patients is associated with discomfort and pain; gas-related symptoms such as bloating and abdominal distension; and abnormal colonic motility. The aim of this study was to assess the postprandial response, i.e., gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant IBS. The study was conducted on 42 IBS patients (14 males, 28 females, mean age 45.1 ± 15.3 years) and 42 healthy participants (16 males, 26 females, mean age 41.1 ± 8.7 years). The study assessed plasma gut peptide levels (gastrin, CCK—Cholecystokinin, VIP—Vasoactive Intestinal Peptide, ghrelin, insulin) and gastric myoelectric activity obtained from electrogastrography (EGG) in the preprandial and postprandial period (meal–oral nutritional supplement 300 kcal/300 ml). Mean preprandial gastrin and insulin levels were significantly elevated in IBS patients compared to the control group (gastrin: 72.27 ± 26.89 vs. 12.27 ± 4.91 pg/ml; p < 0.00001 and insulin: 15.31 ± 12.92 vs. 8.04 ± 3.21 IU/ml; p = 0.0001), while VIP and ghrelin levels were decreased in IBS patients (VIP: 6.69 ± 4.68 vs. 27.26 ± 21.51 ng/ml; p = 0.0001 and ghrelin: 176.01 ± 88.47 vs. 250.24 ± 84.55 pg/ml; p < 0.0001). A nonsignificant change in the CCK level was observed. IBS patients showed significant changes in postprandial hormone levels compared to the preprandial state—specifically, there were increases in gastrin (p = 0.000), CCK (p < 0.0001), VIP (p < 0.0001), ghrelin (p = 0.000) and insulin (p < 0.0001). Patients with IBS showed reduced preprandial and postprandial normogastria (59.8 ± 22.0 vs. 66.3 ± 20.2%) compared to control values (83.19 ± 16.7%; p < 0.0001 vs. 86.1 ± 9.4%; p < 0.0001). In response to the meal, we did not observe an increase in the percentage of normogastria or the average percentage slow-wave coupling (APSWC) in IBS patients. The postprandial to preprandial power ratio (PR) indicates alterations in gastric contractions; in controls, PR = 2.7, whereas in IBS patients, PR = 1.7, which was significantly lower (p = 0.00009). This ratio reflects a decrease in gastric contractility. Disturbances in the postprandial concentration of gut peptides (gastrin, insulin and ghrelin) in plasma may contribute to abnormal gastric function and consequently intestinal motility, which are manifested in the intensification of clinical symptoms, such as visceral hypersensitivity or irregular bowel movements in IBS patients.

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Is Palliative Gastrojejunostomy for Malignant Gastric Outlet Obstruction an Optimal Choice for Very Elderly Patients? A Report from a Long-Lived Country

Yao

Kita²,

Ishikawa³

et al. 2022

Ann Surg Oncol

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Association between gastric myoelectric activity disturbances and dyspeptic symptoms in gastrointestinal cancer patients

Cited by 3 publications

References 32 publications

The effect of visceral reception activation (water load test) on autonomic activity and gastric myoelectric activity in gastrointestinal malignancies

The effect of visceral reception activation (water load test) on autonomic activity and gastric myoelectric activity in gastrointestinal malignancies

Postprandial effect of gastrointestinal hormones and gastric activity in patients with irritable bowel syndrome

Is Palliative Gastrojejunostomy for Malignant Gastric Outlet Obstruction an Optimal Choice for Very Elderly Patients? A Report from a Long-Lived Country

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