Association between Gene Polymorphism of Manganese Superoxide Dismutase and Prostate Cancer Risk

Abstract

Manganese superoxide dismutase (Mn-SOD) is the most effective antioxidant enzyme in mitochondria and protects cells from reactive oxygen species-induced oxidative damage. The aim of this study was to investigate the association between Mn-SOD Ala-9Val gene polymorphism and prostate cancer (PCa) risk in Turkish men with prostate cancer. 33 patients with PCa and 81 control individuals were included in the study. We observed an association between MnSOD Ala/Ala frequency and a higher PCa risk. In addition, we found that the increased risk of early-onset PCa (under age of 65) in the men homozygous for Ala allele was higher than the men homozygous for Val allele. However, we determined that MnSOD Ala-9Val genotype was not associated with the aggressiveness of the disease. The results of our study suggest that MnSOD Ala/Ala genotype may influence on early-onset of PCa patients, but no effect on subsequent development of the disease in Turkish men. However, our study has a limitation that is

Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

“…Overall, 88 studies with 33,098 cases and 37,831 controls were included in this meta-analysis. Of the 88 studies, 24 studies focused on breast cancer [ 9 – 11 , 16 , 38 , 60 , 61 , 68 , 69 , 71 , 72 , 77 , 88 , 93 , 96 , 97 , 100 , 105 , 109 , 114 , 119 , 122 , 127 ]; 17 on prostate cancer [ 37 , 66 , 74 , 79 , 82 , 85 , 86 , 89 , 95 , 106 , 111 , 113 , 120 , 125 , 128 ]; six for each of the following cancer types, such as lung cancer [ 7 , 17 , 18 , 65 , 92 , 118 ], bladder cancer [ 8 , 15 , 67 , 75 , 112 , 117 ], and pancreatic cancer [ 64 , 91 , 102 , 107 , 108 , 121 ]; five on colorectal cancer [ 13 , 63 , 73 , 94 , 101 ]; three for each of the following cancer types, such as ovarian cancer [ 70 , 81 , 87 ], hepatocellular carcinoma [ 98 , 99 , ...…”

Probing the molecular regulation of lipopolysaccharide stress in piglet liver by comparative proteomics analysis

“…SOD2, a key mitochondria manganese‐dependent SOD, which converts superoxide to hydrogen peroxide that is broken down further into water and oxygen by other enzymatic and non‐enzymatic antioxidant . SOD is of great importance in protecting cells from the damages induced by ROS . Souza et al showed that the combination of IL‐1β, TNF‐α and the pro‐inflammatory cytokine increased the level of SOD2 expression in both mRNA and protein levels .…”

Association between Manganese Superoxide Dismutase (MnSOD) Polymorphism and Prostate Cancer Susceptibility: A Meta-Analysis

“…A total of 15 case-control studies including 6,958 cases and 7,961 controls met the inclusion criteria and were involved in the current meta-analysis (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The details of each study are listed in Tables I and II.…”

“…Recently, it has been demonstrated that a T-to-C substitution in the SOD2 gene could result in a valine (Val) to alanine (Ala) amino acid change, thus causing higher MnSOD enzymatic activity. Moreover, a growing number of studies have discovered a connection between the MnSOD Val16Ala polymorphism (rs4880) and the risk of PCa (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Therefore, this single-nucleotide polymorphism might play an important role in prostate carcinogenesis.…”