Association between genetic polymorphisms and deep vein thrombosis in a Chinese population

Jia, Jianjun; Jiao, Yang; Ding, Xiangjiu; Zhang, Bai-gen

doi:10.1016/j.thromres.2015.07.010

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…[27] There were 8 studies with 976 cases and 1780 controls for TFPI rs8176592 polymorphism. All were case-control studies, including 3 venous thromboembolism (VTE) studies, [27,28,34] 3 DVT studies, [29,35,36] 1 venous thrombosis study, [32] and 1 cerebral venous thrombosis (CVT) study. [33] Subjects were sampled from France, Australia, Denmark, Norway, India, Korean, and China.…”

Section: Resultsmentioning

confidence: 99%

“…For example, 5 studies report that TFPI rs8176592 polymorphism was related to the risk of venous thrombosis, [27,28,32,33,36] while 3 studies report it was not. [29,34,35] Amini reported that the TFPI rs10931292 polymorphism was related with venous thrombosis risk. [30] while 4 other studies reported that it was not related to the risk of venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

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Association of TFPI polymorphisms rs8176592, rs10931292, and rs10153820 with venous thrombosis

et al. 2019

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Background: Tissue factor pathway inhibitor ( TFPI ) polymorphisms are known to be involved in venous thrombosis; however, any correlation between the TFPI polymorphisms rs8176592, rs10931292, and rs10153820 and venous thrombosis remains controversial. This meta-analysis aimed to elucidate the relationship between these TFPI polymorphisms and the susceptibility to venous thrombosis. Methods: A literature search for relevant studies was conducted in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Med Online databases. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were calculated using fixed-effect/random-effect models by the STATA 12.0 software. Sources of heterogeneity were analyzed by subgroup analysis. Results: Eleven case-control studies involving 3740 subjects (1362 venous thrombosis patients and 2378 healthy controls) were included. The TFPI rs8176592 polymorphism was associated with increased risk of venous thrombosis in the whole population, while no significant association was found between rs10931292/rs10153820 and venous thrombosis. In subgroup analysis based on ethnicity, an increased risk was observed with rs8176592 polymorphism in Asians (Recessive model, OR = 1.48, 95% CI = 1.06–2.07, P = .023). An increased risk associated with rs10931292 was identified in non-Asians (Recessive model, OR = 1.42, 95% CI = 1.03–1.97, P = .033). No significant association was found in either Asians or non-Asians with the rs10153820 polymorphism. In subgroup analysis based on source of controls, increased risks were identified in the hospital-based group with rs8176592 polymorphism and in the population-based group with rs10931292 polymorphism, whereas decreased risk was identified in the hospital-based group with the rs10931292 and rs10153820 polymorphisms. Conclusion: Meta-analysis suggested that different TFPI polymorphisms may have different associations with venous thrombosis. TFPI rs8176592 polymorphism may increase the risk of venous thrombosis, especially in Asians and hospital-based patients. The TFPI rs10931292 polymorphism may increase the venous thrombosis risk for both non-Asians and population-based patients. Moreover, rs10931292 and rs10153820 polymorphisms of TFPI may decrease the risk of venous thrombosis for hospital-based patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of TFPI polymorphisms rs8176592, rs10931292, and rs10153820 with venous thrombosis

et al. 2019

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“…For example, factor V Leiden mutation is the most common hereditary thrombophilia, with a prevalence of 5% e 10%, although it is rarely seen in non-white populations. 66,67 Different types of recognised thrombophilia are presented in Table 5. The prevalence and relative risk of development of VTE of the most common hereditary and acquired haematological alterations related to clinical thrombophilia is shown in Table 20 in Chapter 4.4.1.…”

Section: Classmentioning

confidence: 99%

Editor's Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis

Kakkos

Gohel²,

Bækgaard

et al. 2021

European Journal of Vascular and Endovascular Surgery

443

323

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“…According to the inclusion and exclusion criteria, 12 literature 24,[26][27][28][29][30][31][32][33][34][35][36] were finally included after a rigorous screening process, including 2980 cases in the case group and 3649 cases in the control group. One of these studies, by Alkeksic et al, 36 was considered as two separate studies based on various populations because it included Caucasians and African Americans.…”

Section: Study Characteristicsmentioning

confidence: 99%

Effect of thrombomodulin gene polymorphisms on venous thromboembolism: An analysis of evidence involving 6,629 patients

et al. 2022

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Backgroud The association between thrombomodulin gene (THBD) c.1418 C>T polymorphisms and the risk of venous thromboembolism (VTE) is controversial. The purpose of this meta-analysis was to evaluate THBD c.1418 C>T polymorphisms and the risk of VTE. Methods Computer searches were performed on the CNKI, Wanfang database, VIP database, PubMed, Embase, Web of Science, and Cochrane Library databases. The retrieval time limit was from the establishment of the database to June 2022. Case-control studies and cohort studies of THBD c.1418 C>T polymorphisms associated with VTE were included. The literature was screened according to inclusion and exclusion criteria, data extraction and literature quality evaluation. Meta-analysis was performed using STATA 14.0 software. Results A total of 12 literature were included, including 2980 cases in the case group and 3649 cases in the control group. The meta-analysis results showed no significant association of the THBD c.1418 C> T polymorphisms with the occurrence of VTE (T vs C: OR = 1.17, 95%CI = 0.93–1.48; TT vs CT+CC: OR = 1.00, 95%CI = 0.75–1.33; TT+CT vs CC: OR = 1.22, 95%CI = 0.94–1.59). Subgroup analyses revealed an increased risk of VTE in Asian populations due to THBD c.1418 C>T polymorphisms (T vs C: OR = 1.48, 95%CI = 1.06–2.07; TT vs CT+CC: OR = 1.80, 95%CI = 1.13–2.85; TT+CT vs CC: OR = 1.58, 95%CI = 1.07–2.32). THBD c.1418 C>T polymorphisms increased the risk of DVT (T vs C: OR = 1.51, 95%CI = 1.24–1.85; TT vs CT+CC: OR = 1.85, 95%CI = 1.10–3.12; TT+CT vs CC: OR = 1.64, 95%CI = 1.28–2.11). THBD c.1418 C>T polymorphisms reduced the risk of VTE in non-Asian populations (TT vs CT+CC: OR = 0.66, 95%CI = 0.45–0.98). Conclusion THBD c.1418 C>T polymorphisms is associated with VTE in Asian population, which may be a factor in the occurrence of VTE in Asian population. THBD c.1418 C>T polymorphisms increases the risk of DVT. Given the limitations of this meta-analysis, the conclusions require being further supported by large-scale and high-quality studies.

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Association between genetic polymorphisms and deep vein thrombosis in a Chinese population

Cited by 5 publications

References 23 publications

Association of TFPI polymorphisms rs8176592, rs10931292, and rs10153820 with venous thrombosis

Association of TFPI polymorphisms rs8176592, rs10931292, and rs10153820 with venous thrombosis

Editor's Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis

Effect of thrombomodulin gene polymorphisms on venous thromboembolism: An analysis of evidence involving 6,629 patients

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