Association between Genetic Polymorphisms in Superoxide Dismutase Gene Family and Risk of Gastric Cancer

Eftekhari, Alireza; Peivand, Zahra; Saadat, Iraj; Saadat, Mostafa

doi:10.1007/s12253-018-0470-0

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…Association studies on the rs5746136 variants of SOD2 and BC remain unknown. However, this variant has been associated with a susceptibility of increased risk in smokers with gastric cancer [ 34 ] and with polycystic ovary syndrome [ 35 ]. It is also associated with a susceptibility of bladder cancer [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

Gallegos‐Arreola

Ramírez-Patiño

Sánchez-López

et al. 2022

CIMB

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The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the SOD2 gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the CT, TT, CTCC, and the T alleles (p < 0.05). The CT genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (p < 0.05). The rs4880 variant was associated with BC patients with CTTT genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (p < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (p < 0.05) in BC patients who carry TT, TC, and CTTT genotypes, respectively. The haplotype T/T (OR 1.98; 95% CI 1.20–3.26, p = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility.

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Section: Discussionmentioning

confidence: 99%

SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

Gallegos‐Arreola

Ramírez-Patiño

Sánchez-López

et al. 2022

CIMB

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“…[31] Another study showed that SOD2 polymorphisms were associated with an increased GC risk. [32] The results suggest that SOD has potential value in monitoring the degree of inflammatory injury to the gastric mucosa and gastric tumor formation.…”

Section: Observationsmentioning

confidence: 99%

Effects of oxidative stress regulation in inflammation-associated gastric cancer progression treated using traditional Chinese medicines: A review

Chen,

Dong,

Zhang

et al. 2023

Medicine

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Gastric cancer (GC) is a global public health concern that poses a serious threat to human health owing to its high morbidity and mortality rates. Due to the lack of specificity of symptoms, patients with GC tend to be diagnosed at an advanced stage with poor prognosis. Therefore, the development of new treatment methods is particularly urgent. Chronic atrophic gastritis (CAG), a precancerous GC lesion, plays a key role in its occurrence and development. Oxidative stress has been identified as an important factor driving the development and progression of the pathological processes of CAG and GC. Therefore, regulating oxidative stress pathways can not only intervene in CAG development but also prevent the occurrence and metastasis of GC and improve the prognosis of GC patients. In this study, PubMed, CNKI, and Web of Science were used to search for a large number of relevant studies. The review results suggested that the active ingredients of traditional Chinese medicine (TCM) and TCM prescriptions could target and improve inflammation, pathological status, metastasis, and invasion of tumor cells, providing a potential new supplement for the treatment of CAG and GC.

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“…SOD1 expression is significantly down-regulated under oxidative stress, for example it is decreased in morphine treated human SH-SY5Y cells ( 13 ), and in cells exposed to electromagnetic fields ( 14 ). SOD1 Ins/Del genetic variation is related with complex human diseases associated with oxidative stress, such as breast and gastric cancers, age of onset of bipolar disorder, and cardiovascular disease ( 15 , 16 , 17 , 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the <i>SOD1</i> gene

Namdari¹,

Saadat²

2021

J Turkish German Gynecol Assoc

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Objective: There is much evidence that oxidative stress is involved in the pathogenesis of preeclampsia (PE). A 50 bp insertion/deletion (Ins/Del) functional polymorphism in the promoter region of SOD1 has been reported. Due to a total lack of data, the aim of this study was to investigate the association between the SOD1 (Ins/Del) polymorphism and the risk of PE. Material and Methods: The current hospital-based case-control study included a total of 172 preeclamptic and 171 non-preeclamptic pregnancies. Genotyping was performed using the polymerase chain reaction method. Results: Statistical analysis revealed that the Del/Del genotype significantly correlated with susceptibility to PE [odds ratio (OR): 6.53, 95% confidence interval (CI): 1.43-29.7, p=0.015]. Since maternal body mass index, family history of PE in first degree relatives, and educational levels were statistically associated with the susceptibility to PE, further analyses were carried out in order to estimate the adjusted ORs. After adjustment for aforementioned variables, the Del/Del genotype increased the risk of PE (OR: 5.98, 95% CI: 1.21-29.5, p=0.028). Conclusion: The 50 bp Ins/Del in promoter region of the SOD1 gene could be an intriguing susceptibility factor for developing preeclampsia in Iranian Caucasians.

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Association between Genetic Polymorphisms in Superoxide Dismutase Gene Family and Risk of Gastric Cancer

Cited by 9 publications

References 30 publications

SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

Effects of oxidative stress regulation in inflammation-associated gastric cancer progression treated using traditional Chinese medicines: A review

Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the <i>SOD1</i> gene

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