Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Moriyama, Ayako; Nishizawa, Daisuke; Kasai, Shinya; Hasegawa, Junko; Fukuda, Ken‐ichi; Nagashima, Makoto; Katoh, Ryoji; Ikeda, Kazutaka

doi:10.1254/jphs.12159fp

Cited by 23 publications

(14 citation statements)

References 30 publications

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“…PCR amplification of G1165C was performed using primers mentioned in Table 1. Genotyping of G1165C was done as described previously by Moriyama et al (32). An Eppendorf gradient Master cycler (Hamburg, Germany) PCR machine was used as the thermal cycler.…”

Section: Sertralinementioning

confidence: 99%

Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients

et al. 2017

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-Purpose: The adrenoceptor family, as one of the main contributors in regulating the noradrenergic system, has been studied in involvement of depression and its treatment. A functional polymorphism of G1165C on beta adrenoceptor (βAR) enhances post receptor signalling and is assumed to be involved in pharmacotherapy of depression. The aim of the present study was to discern the influence of G1165C polymorphism in the β1AR gene on individual differences in response to sertraline. Methods: One hundred newly diagnosed patients completed 6 weeks of sertraline treatment. Response to treatment was defined as a 50% decrease in Hamilton Rating Scale for depression (HRSD). Results: The patients who carried CC genotype responded five times more to sertraline comparing with other variants (P=0.005; OR=5.7; 95%CI=1.4-23.9). Moreover, carriers of C allele responded three times more to sertraline than patients with the G allele (P=0.001; OR= 3.3; 95%CI= 1.72-6.50). Conclusion:In conclusion, our results support the hypothesis that genetic variation of β1AR might influence clinical response to sertraline.

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Section: Sertralinementioning

confidence: 99%

Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients

et al. 2017

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“…rs1801252 and rs1801253 are embedded single nucleotide polymorphisms (SNPs) in ADRB1 gene with clinical significance in hypertension, stroke, heart disease, pain and analgesic sensitivity. In Chinese population, different response according to variety of rs1801252 and rs1801253 SNPs to pain is reported, also Japanese population response to Fentanyl is affected by these SNPs [69][70][71].…”

Section: Enzyme Catechol-o-methyl Transferase (Comt)mentioning

confidence: 99%

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Kafshdooz

Kahroba

Kafshdooz

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Labour is considered to be one of the most painful procedures in human experience. The most effective technique for pain relief during labour is neuraxial labour analgesia which provides analgesia without maternal or fetal sedation. Genetic predisposition may be of importance for pain perception and women experience varying degrees of pain in labour. Genetic variations in opioid receptor (OPR) genes may influence the response to epidural opioid analgesia during labour. The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. Targeted drug delivery reduces toxic side effects. Liposomes, nano-particles, nanofibres hydrogel, have been suggested to deliver anaesthetic drugs.

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“…In the present study, except for OPRM1, ABCB1, UGT2B7, and P2RX7, we selected other 14 genes known to be involved in systems related to pain perception and modulation based on evidence in the literature. The selected genes have been related to the ion channels (SCN9A, SCN10A, SCN11A, KCNJ6, TRPV1, and CACN A1E) [15][16][17][18][19][20], dopaminergic system (COMT, DRD2) [21,22], purinergic receptor (P2RY12) [23], adrenergic receptor (ADRB1) [24], estrogen receptor (ESR1) [25], serine/ threonine kinase (TAOK3) [26], growth factors (TGFB1) [27], and transcription factor (CREB1) [28]. The aim of the present study was to evaluate the association of common SNPs among aforementioned genes with the inadequate analgesia after single-port VATS.…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population

et al. 2020

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Background: Postoperative inadequate analgesia following video-assisted thoracoscopic surgery (VATS) is a common and significant clinical problem. While genetic polymorphisms may play role in the variability of postoperative analgesia effect, few studies have evaluated the associations between genetic mutations and inadequate analgesia after single-port VATS. Methods: Twenty-eight single nucleotide polymorphisms (SNPs) among 18 selected genes involved in pain perception and modulation were genotyped in 198 Chinese patients undergoing single-port VATS. The primary outcome was the occurrence of inadequate analgesia in the first night and morning after surgery which was defined by a comprehensive postoperative evaluation. Multivariable logistic regression analyses were used to identify the association between genetic variations and postoperative inadequate analgesia. Results: The prevalence of postoperative inadequate analgesia was 45.5% in the present study. After controlling for age and education level, association with inadequate analgesia was observed in four SNPs among three genes encoding voltage-gated sodium channels. Patients with the minor allele of rs33985936 (SCN11A), rs6795970 (SCN10A), and 3312G > T (SCN9A) have an increased risk of suffering from inadequate analgesia. While the patients carrying the minor allele of rs11709492 (SCN11A) have lower risk experiencing inadequate analgesia. Conclusions: We identified that SNPs in SCN9A, SCN10A, and SCN11A play a role in the postoperative inadequate analgesia after single-port VATS. Although future larger and long-term follow up studies are warranted to confirm our findings, the results of the current study may be utilized as predictors for forecasting postoperative analgesic effect for patients receiving this type of surgery. Trial registration: This study was retrospectively registered in the ClinicalTrials.gov Registry (NCT03916120) on April 16, 2019.

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Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Cited by 23 publications

References 30 publications

Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients

Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population

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