Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population

Abstract

Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3′ side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, P=0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations.

Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer

“…Several studies have explored the association between the XPG gene rs2094258 polymorphism and susceptibility to GC among Chinese populations. However, no association was revealed by the first case‐control study with 1125 GC cases and 1196 controls or the subsequent studies . It is worth noting that a Chinese study of 337 GC cases and 347 controls reported that individuals harboring the rs2094258 polymorphism and H .…”

“…For instance, a case‐control study of 1125 GC cases and 1196 controls does not imply any association . Another study with 1142 GC cases and 1173 controls replicates negative findings, but shows individuals carrying 3‐4 risk genotypes are at significantly higher risk of GC than those with 0‐2 risk genotypes, which indicate the interaction between rs2094258 polymorphism and other SNPs. Such disparity may be attributed to the clinical heterogeneity, small sample sizes, and different geographic locations.…”

Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

“…We carried out genotyping on the platform of the TaqMan real-time PCR method on a 7900 Sequence Detection System (Applied Biosystems, Foster City, CA). The technique details were described previously 40, 41, 42. Quality control was strictly executed; four duplicate positive controls and four negative controls (omitting DNA template) were loaded, along with samples in each of the 384-well plates.…”

LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four‐centre case‐control study

“…If a genotype of a SNP was shown to increase neuroblastoma risk (OR > 1), the genotype was regarded as a risk genotype. Carriers of 3 risk genotypes represented those carrying three risk genotypes of the four SNPs, while 1‐4 risk genotypes represented those carrying 1‐4 risk genotypes . The stratification analyses were also performed to identify the associations by age, gender, sites of origins and clinical stages.…”