Association between genetic variants in the CD209 gene and susceptibility to COVID-19 in Iranian population

Nagozir, Sina; Khomartash, Mehdi Shakouri; Parsania, Masoud; Vahidi, Mahmoud; Ghorbani, Mahdi

doi:10.1016/j.humgen.2023.201215

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…The Human ortholog of Cd209c is implicated in Coronavirus infectious disease, 24 aspergillosis, 25 dengue disease, 26 and tuberculosis. 27…”

Section: Novel Complex Structural Variants Discovered From the Graph ...mentioning

confidence: 99%

“…21 In mice, Pilrb1l1 is abundantly expressed on myeloid cells, and required for cell movement out of the circulatory system and towards the site of tissue damage or infection. 22 Pilrb−/− mice have reduced serum or bronchoalveolar lavage fluid levels of tumor necrosis factor alpha (TNF-α) 23 suggesting that increased CGA expression and consequent TNF-α production might compensate the lack of function of Pilrb1l1. The relationship between increased CGA expression, and insulin concentration aligns with previous findings, chromogranin A regulates catecholamine storage and release, variation affecting CGA levels could impact catecholamines that can suppress insulin secretion and affect glucose metabolism.…”

Section: Novel Pangenome Variants Associated With Glucose Insulin And...mentioning

confidence: 99%

“…It contains a Lx8b_3end, a non-LTR retrotransposon in rodents (LINE). The Human ortholog of Cd209c is implicated in Coronavirus infectious disease, 23 aspergillosis, 24 dengue disease, 25 and tuberculosis. 26 9…”

Section: Novel Complex Structural Variants Discovered From the Pangenomementioning

confidence: 99%

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Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery

Villani,

Guarracino,

Ward

et al. 2024

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The HXB/BXH family of recombinant inbred rat strains is a unique genetic resource that has been extensively phenotyped over 25 years, resulting in a vast dataset of quantitative molecular and physiological phenotypes. We built a pangenome graph from 10x Genomics linked-read data for 31 recombinant inbred rats to study genetic variation and association mapping. The pangenome length was on average 2.4 times greater than the corresponding length of the reference mRatBN7.2, confirming the capture of substantial additional variation. We validated variants in challenging regions, including complex structural variants resolving into multiple haplotypes. Phenome-wide association analysis of validated SNPs uncovered variants associated with glucose/insulin levels and hippocampal gene expression. We propose an interaction between Pirl1l1, Cromogranine expression, TNF-α levels, and insulin regulation. This study demonstrates the utility of linked-read pangenomes for comprehensive variant detection and mapping phenotypic diversity in a widely used rat genetic reference panel.

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“…The Human ortholog of Cd209c is implicated in Coronavirus infectious disease, 24 aspergillosis, 25 dengue disease, 26 and tuberculosis. 27…”

Section: Novel Complex Structural Variants Discovered From the Graph ...mentioning

confidence: 99%

Section: Novel Pangenome Variants Associated With Glucose Insulin And...mentioning

confidence: 99%

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Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery

Villani,

Guarracino,

Ward

et al. 2024

Preprint

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Comparison of RT-LAMP and RT-qPCR assays for detecting SARS-CoV-2 in the extracted RNA and direct swab samples

Pourakbari,

Gholami,

Shakerimoghaddam

et al. 2024

Journal of Virological Methods

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SARS-CoV-2 and Environmental Changes: The Perfect Storm

Caldarelli,

Rio,

Giambra

et al. 2024

CIMB

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The COVID-19 pandemic has had a significant impact on the global economy. It also provided insights into how the looming global climate crisis might be addressed, as there are several similarities between the challenges proposed by COVID-19 and those expected from the coming climate emergency. COVID-19 is an immediate health threat, but climate change represents a more gradual and insidious risk that will lead to long-term consequences for human health. Research shows that climate change, air pollution and the pandemics have a negative impact on health. Recent studies show that COVID-19 mortality increases with climate extremes. The goal of our review is to analyze the clinical findings of COVID-19 and how they are affected by the climate change, while also providing insight into the emergence of new variants and their ability to evade the immune system. We selected and synthesized data from primary studies, reviews, meta-analyses, and systematic reviews. Selection was based on rigorous methodological and relevance criteria. Indeed, a new variant of SARS-CoV-2, named JN.1, has emerged as the dominant, first in the United States and then worldwide; the variant has specific mutations in its spike proteins that increase its transmissibility. According to the World Health Organization (WHO), JN.1 is currently the most reported variant of interest (VOI), having been identified in 132 countries. We highlight the link between climate change and pandemics, emphasizing the need for global action, targeted medical approaches and scientific innovation.

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Association between genetic variants in the CD209 gene and susceptibility to COVID-19 in Iranian population

Cited by 3 publications

References 26 publications

Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery

Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery

Comparison of RT-LAMP and RT-qPCR assays for detecting SARS-CoV-2 in the extracted RNA and direct swab samples

SARS-CoV-2 and Environmental Changes: The Perfect Storm

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