Association Between Gestational Diabetes Mellitus and Future Risk of Kidney Stones

Mao, Yuanyuan; Hu, Wenbin; Liu, Li; Liu, Qin

doi:10.3389/fpubh.2022.843383

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…In addition, GDM history was based on self-report and misclassification may be of concern. Nevertheless, data from NHANES are considered valid for assessing the prevalence of GDM in the general population [ 42 – 44 ]. Finally, because the current study focused on women aged 20–49 years in the United States, the results cannot be generalized to all age groups.…”

Section: Discussionmentioning

confidence: 99%

Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Zeng,

Yin,

Yin

et al. 2024

BMC Public Health

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Objective The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating role of serum total cholesterol (TC). Methods In this cross-sectional study, 1809 women aged 20–49 years with at least one live birth between 2011 and 2018, drawn from the NHANES dataset, were analyzed. GDM history was identified through questionnaires. Using weighted multiple linear regression, we assessed the relationship between GDM history and lumbar BMD. Additionally, mediation analysis was performed to investigate the potential mediating role of TC. Results The fully adjusted linear regression model revealed a negative association between a history of GDM and lumbar BMD, indicating a reduction in lumbar BMD (β = -0.023, 95% CI: -0.043, -0.003, P = 0.0275). Subgroup analysis highlighted a more pronounced trend in individuals aged ≥ 35 years and with a body mass index ≥ 30 kg/m². Furthermore, mediation analysis demonstrated a significant direct effect of a history of GDM on lumbar BMD (P < 0.0001), with serum TC playing a partial mediating role in this interaction (5.33%, P = 0.028). Conclusions In women aged 20–49 years within the United States, a history of GDM was associated with diminished lumbar BMD, potentially mediated through serum TC.

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Section: Discussionmentioning

confidence: 99%

Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Zeng,

Yin,

Yin

et al. 2024

BMC Public Health

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“…Data on history of hypertension, hyperlipidemia, and diabetes mellitus was obtained from participants' self-reported health questionnaires [24,25] .…”

Section: Covariatesmentioning

confidence: 99%

Association of novel inflammatory markers with gestational diabetes mellitus in a representative U.S. sample: evidence from NHANES 2007-2018

Chen,

Zeng,

et al. 2024

Preprint

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Background Early detection of gestational diabetes mellitus (GDM) can lower the chance of occurrence. Recent years have seen a surge in research on novel inflammatory indicators, such as systemic immune inflammatory index (SII), lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR). Inflammation is linked to the pathophysiology of GDM and can be targeted for treatment. However, the relationship between GDM and these novel inflammatory markers is unclear. Methods We included participants with a diagnosis of GDM who were between the ages of 20 and 44, as well as complete blood counts from the US National Health and Nutrition Examination conducted between 2007 and 2018. SII, LMR, NLR, and PLR were among the novel inflammatory markers. First, we logarithmically transformed the exposure components to account for skewed distribution. We tested the relationship between GDM and novel inflammatory markers using a multiple logistic regression model and subgroup analyses to analyze the stability. And RCS curves were created to evaluate the non-linear connection. Results Following the inclusion of 3,722 women aged 20–44 years with GDM, multivariate logistic regression analysis revealed a positive correlation between log2-LMR and GDM (OR = 1.55, 95% CI = 1.20–2.01, p = 0.001), while negative correlations were observed between log2-SII, log2-PLR, and log2-NLR with GDM (OR = 0.84, 95% CI = 0.71–0.99, p = 0.04; OR = 0.73, 95% CI = 0.56–0.94, p = 0.01; OR = 0.65, 95% CI = 0.47–0.97, p = 0.03), and the correlation remained significant even after controlling for all confounders. Correlations were consistently shown by subgroup analyses. When the log2-LMR value was less than 1.79, the risk of GDM reduced with rising log2-LMR, and this tendency was reversed when larger than 1.79. Conclusions Elevated levels of new inflammatory markers are correlated with an increased risk of GDM and may offer clinicians with information to screen for GDM and identify GDM therapeutic targets. Further studies are required to investigate the causal relationship between the new inflammatory markers and GDM.

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“…Nevertheless, after controlling for these covariates, the correlation remained significant. The authors noted that the study's cross-sectional design made it impossible to determine a cause-and-effect relationship between variables (16).…”

Section: Gdm and Kidney Stonesmentioning

confidence: 99%

The adverse effects of gestational diabetes mellitus on maternal and neonatal kidneys

Hassanzadeh Rad,

Nazeri

2023

J Nephropharmacol

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Gestational diabetes mellitus (GDM) is a complication of pregnancy defined as any level of early or first detection of glucose intolerance in pregnancy. It is a prevalent metabolic disorder associated with several maternal and neonatal complications. On the other hand, chronic kidney disease is a leading cause of premature morbidity and mortality worldwide, and diabetic nephropathy accounts for approximately half of all cases of end-stage renal disease. Due to these two conditions’ high prevalence and significance, any possible association would be a public health concern requiring further investigation. To this end, the current study aimed to review the adverse effects of GDM on maternal and neonatal kidneys.

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Association Between Gestational Diabetes Mellitus and Future Risk of Kidney Stones

Cited by 5 publications

References 31 publications

Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Association of novel inflammatory markers with gestational diabetes mellitus in a representative U.S. sample: evidence from NHANES 2007-2018

The adverse effects of gestational diabetes mellitus on maternal and neonatal kidneys

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