Association between glaucoma severity and driving cessation in subjects with primary open-angle glaucoma

Abstract

BackgroundThe aim of this study, which included a baseline cross-sectional study and a 3-year follow-up prospective study, was to investigate the association between glaucomatous visual field damage and driving cessation in subjects with primary open-angle glaucoma (POAG).MethodsA total of 211 POAG subjects divided into 3 groups according to POAG severity (mild, moderate, or severe) in the better eye were enrolled along with 148 control subjects; subjects were asked about changes in their driving status. In the 3-year follow-up study, 185 of the POAG subjects and 80 of the controls annually reported their driving status. Adjusted odds ratios and 95% confidence intervals for the prevalence and incidence of driving cessation were estimated with a multiple logistic regression model.ResultsIn the original cross-sectional study, 11/148 (7%) members of the control group reported having given up driving over the previous 5 years; the corresponding figures for the mild POAG, moderate POAG, and severe POAG groups were 9/173 (5%), 0/22 (0%), and 5/16 (31%), respectively (p = 0.001, Fisher’s exact test), with severe POAG found to be associated with driving cessation after adjustment for age, gender, systemic hypertension, and diabetes mellitus (odds ratio 11.52 [95% CI 2.87-46.35], ref. control, p = 0.001). In the follow-up study, the proportions of subjects who ceased driving were 1/80 (1.3%) in the control group, 8/152 (5.3%) in the mild POAG group, 5/22 (22.7%) in the moderate POAG group, and 2/11 (18.2%) in the severe POAG group (p = 0.001, Fisher’s exact test). Moderate POAG and severe POAG in the better eye were found to be associated with driving cessation after adjustment for age, gender, systemic hypertension, and diabetes mellitus (moderate POAG in the better eye: odds ratio 37.7 [95% CI 3.7-383.8], ref. control, p = 0.002, and severe POAG in the better eye: odds ratio 52.8 [95% CI 3.5-797.0], ref. control, p = 0.004).ConclusionModerate and Severe POAG in the better eye is associated with driving cessation.

Associations between vision impairment and vision-related interventions on crash risk and driving cessation: systematic review and meta-analysis

“…Raw data on studies reporting on MVCs15–81 and driving cessation70–73 82–115 can be found in online supplemental appendix 4A,B, respectively, with additional narrative summaries. Meta-analyses on associations are presented in online supplemental appendix 5A,B; only 25 studies could be meta-analysed.…”

“…There were 13 studies (n=21 939) investigating associations between glaucoma and the likelihood of driving cessation with estimates ranging from an increased risk of 1.3 to increased odds of 4 70–72 87 91 92 99 100 103 109–111 113. The meta-analysis in online supplemental appendix 5B suggests a diagnosis of glaucoma to increase the risk of driving cessation by 63% (95% CI 1.20% to 2.19%; p<0.01)87 91; however, this analysis only contained two studies.…”

Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital

“…A sample size of 94 was calculated by Rao soft calculator keeping confidence level 95 percent. POAG was diagnosed with at least two readings of IOP above 21 mm Hg by Goldmann tonometry, an open angle on gonioscopy or Visual field defects on Humphrey perimetry (14). Exclusion criteria included Patients presenting with secondary causes of glaucoma, normal tension glaucoma and acute angle closure glaucoma.…”

“…A thorough ophthalmic examination of POAG patients and controls was carried out by an experienced eye specialist. Glaucoma cases were graded as mild, moderate and severe based on visual field defects on Humphrey perimetry (14). A 7 ml venous blood sample was taken from POAG patients for pathology lab tests.…”

Performance na condução de automóvel por pacientes portadores de glaucoma primário de ângulo aberto: atenção dividida e discriminação de objetos

“…Diante desse contexto, uma espiral de sentimentos e comportamentos, como parar de conduzir, pode levar ao isolamento social e, em última análise, à depressão e à diminuição da mobilidade e QV (46,65,(80)(81)(82) .…”