Association Between Glycosylated Hemoglobin Level and 16-Year Incidence of Chronic Kidney Disease in Type 1 Diabetes

Shankar, Anoop; Klein, RW; Klein, Barbara E. K.; Moss, Scot E.

doi:10.1055/s-2007-956170

Cited by 10 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a prospective study of subjects with type 1 diabetes, retinal venular widening was found to be associated with incident CKD 11. However, subjects with younger onset type 1 diabetes may have a different baseline risk of kidney disease than the general population due to the presence of hyperglycemia, a risk factor for kidney disease, from a young age 13. Two other prospective studies conducted in general population samples reported mutually inconsistent findings 10…”

mentioning

confidence: 99%

Bidirectional Association of Retinal Vessel Diameters and Estimated GFR Decline: The Beaver Dam CKD Study

Sabanayagam

Shankar

Klein

et al. 2011

American Journal of Kidney Diseases

View full text Add to dashboard Cite

Background-Recent cross-sectional studies have reported an association between retinal vessel caliber and chronic kidney disease (CKD), but the direction of the association between these two processes is not clear. In a prospective study with multiple measurements of retinal vessel diameters and serum creatinine, we examined if baseline retinal vessel diameters are associated with future risk of CKD, or vice versa.

show abstract

mentioning

confidence: 99%

Bidirectional Association of Retinal Vessel Diameters and Estimated GFR Decline: The Beaver Dam CKD Study

Sabanayagam

Shankar

Klein

et al. 2011

American Journal of Kidney Diseases

View full text Add to dashboard Cite

show abstract

“…This is consistent with the fact that there were improvements in diabetes management strategies closely coinciding with period of diagnosis. Hyperglycemia has been associated with various stages of kidney disease (13,19,29). Glycemic control only explained a portion of the risk for ESRD, consistent with other reports (9,33,34).…”

Section: Discussionmentioning

confidence: 99%

“…HbA 1c was then determined at the 20- and 25-year exams by high-performance liquid chromatography (Tosoh Medics, Inc., San Francisco, CA) at the University of Minnesota laboratory, calibrated using standard values derived by the National Glycohemoglobin Standardization Program. At the 4–14-year visits, serum creatinine was measured using a modification of the Jaffe reaction (13) and at subsequent visits by an enzymatic rate reflectance spectrophotometric method found similar to the Jaffe method (regression equation R 2 = 0.94) (19). Jaffe method–based measures were converted to the spectrophotometric method values by the following equation: spectrophotometric value = 0.9435 × Jaffe method + 0.0435.…”

Section: Methodsmentioning

confidence: 99%

“…Estimated glomerular filtration rate (eGFR) was calculated using the creatinine-based equation developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) in mL/min/1.73 m 2 (20). Urine protein levels were determined on a casual urine sample using an agglutination inhibition assay and reagent strip test (19) (Labstix; Ames, Elkhart, IN) and categorized as gross proteinuria when ≥0.3 g/L.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Risk for End-Stage Renal Disease Over 25 Years in the Population-Based WESDR Cohort

et al. 2014

View full text Add to dashboard Cite

OBJECTIVEIn the population-based Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) cohort, we sought to examine whether a decline in the prevalence and incidence of end-stage renal disease (ESRD) was evident with increasing calendar year of type 1 diabetes diagnosis among people followed for 25 years. Factors associated with the hazard of incident ESRD that may mediate a decline were also investigated.RESEARCH DESIGN AND METHODSParticipants were examined at baseline in 1980 (n = 996) and at 4–25 years of follow-up. ESRD was defined by self-reported renal transplant or dialysis. Cumulative incidence with competing risk of death was determined. Incident ESRD was modeled by period of diagnosis, adjusting for other known risk factors using discrete time hazard models.RESULTSWhen diabetes was diagnosed during 1970–1980, the unadjusted cumulative incidence of ESRD at 25 years was 9.3%. The unadjusted hazard of ESRD was reduced by 70% (P < 0.001), compared with those diagnosed with diabetes in 1922–1969; however, the association was attenuated by glycosylated hemoglobin level (HbA1c), systolic blood pressure, and antihypertensive use (hazard ratio [HR] 0.89 [95% CI 0.55–1.45]). HbA1c, age, and male sex remained associated with ESRD hazard after adjustment for kidney function and proliferative retinopathy.CONCLUSIONSA lower incidence of ESRD among those more recently diagnosed with type 1 diabetes was explained by improvements in glycemic and blood pressure control over the last several decades. Intensive diabetes management, especially for glycemic control, remains important even in long-standing diabetes as it may delay the development of ESRD.

show abstract

“…1) is the final oxidation product of purine metabolism in humans and other higher primates. The concentration levels of uric acid in serum and urine are associated with various diseases, such as cardiovascular disease, renal disease, diabetes, and hypertension, [1][2][3][4][5][6][7][8][9] and are routinely determined especially in clinical and biomedical laboratories. Creatinine ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Creatinine and Uric Acid in Human Urine by High-Performance Liquid Chromatography

et al. 2008

View full text Add to dashboard Cite

An environmentally friendly reversed-phase HPLC method for simultaneous determination of creatinine and uric acid in human urine samples has been developed. Human urine samples were pretreated by dilution, protein precipitation, centrifugation and filtration, followed by HPLC separations using a reversed-phase C18 column with an aqueous mobile phase of phosphate buffer. The retention loss of a C18 column when using the highly aqueous mobile phases was avoided by employing a gradient elution using a small volume (<0.23 mL) of acetonitrile and phosphate buffer at pH 4.75. This developed method provides a simple, rapid separation and sensitive detection for the species of interest in 10 min with UV detection at 205 nm. Quantitation was carried out by relating the peak areas of the identified compounds to that of hypoxanthine as an internal standard. The detection limits for creatinine and uric acid were 0.045 and 0.062 mg mL -1 , respectively. The recoveries of the standards added to urine samples were 87.3 -102.2% for creatinine and 97.3 -108.6% for uric acid, and the relative standard deviation for both analytes was less than 1.0%. This method has been successfully applied to estimating of creatinine and uric acid in human urine.

show abstract

Association Between Glycosylated Hemoglobin Level and 16-Year Incidence of Chronic Kidney Disease in Type 1 Diabetes

Abstract: Higher baseline glycosylated hemoglobin levels are independently associated with incident CKD and ESRD, among individuals with type 1 diabetes.

Cited by 10 publications

References 11 publications

Bidirectional Association of Retinal Vessel Diameters and Estimated GFR Decline: The Beaver Dam CKD Study

Bidirectional Association of Retinal Vessel Diameters and Estimated GFR Decline: The Beaver Dam CKD Study

Risk for End-Stage Renal Disease Over 25 Years in the Population-Based WESDR Cohort

Simultaneous Determination of Creatinine and Uric Acid in Human Urine by High-Performance Liquid Chromatography

Contact Info

Product

Resources

About