Association Between Haptoglobin Phenotype and Microvascular Obstruction in Patients With STEMI

Abstract

Hp phenotype is an independent predictor of MVO. Therefore, Hp phenotyping could be used for risk stratification and may be useful in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI.

The Applications of Artificial Intelligence in Cardiovascular Magnetic Resonance—A Comprehensive Review

“…Cardiac magnetic resonance has demonstrated the ability to prognosticate various cardiovascular conditions [ 6 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ]. Cheng et al showed that greater heterogenicity of LGE in patients with HCM and systolic dysfunction was associated with adverse events [ 99 ].…”

Index of microcirculatory resistance predicts long term cardiac systolic function in patients with STEMI undergoing primary PCI

“…The target study population was eligible for participation if they were between 18 and 75 years of age, had anterior wall STEMI and chest pain within 12 h, received emergence PCI and presented TIMI grade 0-1 grade during invasive coronary angiography (CAG). The exclusion criteria were as follows: (1) patient undergoing cardiopulmonary resuscitation; (2) patient with heart function grade 3 or 4 (Killip classification) and systolic blood pressure < 90 mmHg; (3) with a history of old myocardial infarction or history of coronary artery bypass grafting (CABG); (4) LAD unsuited stent implantation; (5) patients had thrombolysis before pPCI; (6) had contraindication of adenosine triphosphate (ATP); (7) had a history of liver or renal function dysfunction; (8) had major bleeding events during the past 6 weeks; (9) unable to provide informed consent; and (10) had pregnancy or life span < 1 year. Heart failure was defined as hospitalization because of signs and symptoms of heart failure with noninvasive imaging findings and a discharge diagnosis of heart failure.…”

“…Author details 1 Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. 2 Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing 210008, China.…”

“…Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common causes of death in both the developed and developing world [1]. Immediate coronary revascularization by pPCI within 90 min is the gold standard reperfusion therapy for patients with acute STEMI [2]. Despite successful reperfusion of the epicardial coronary artery, a significant proportion of patients with STEMI treated with pPCI fail to achieve adequate myocardial reperfusion due to microvascular system injury and dysfunction [3].…”

Endothelial Microvascular Dysfunction and Its Relationship with Haptoglobin Levels in Patients with Different Phenotypes of Chronic Heart Failure

“…Количество гаптоглобина, циркулирующее в плазме крови здорового человека, является достаточным для связывания до 3 г свободного гемоглобина [11], в условиях воспаления его содержание значительно увеличивается. При нарушении данного механизма свободно циркулирующий гемоглобин, гем и железо начинают участвовать в окислительновосстановительных реакциях, что приводит к высвобождению свободных радикалов с мощной окислительной активностью, что, в свою очередь, способствует развитию иммуновоспалительного синдрома, повреждению эндотелия капилляров и циркуляторной гипоксии, которая взаимосвязана с микроциркуляторными нарушениями при ХСН [11][12][13]. Однако до настоящего времени отсутствуют исследования, посвященные изучению уровня гаптоглобина у больных ХСН и оценке его взаимосвязей с микроциркуляторной дисфункцией у больных ХСН, что и определило цель нашего исследования: изучить взаимосвязи уровня гаптоглобина и основных показателей микроциркуляции (МКЦ) у пациентов с разными фенотипами ХСН.…”