Association between hematocrit and the 30-day mortality of patients with sepsis: A retrospective analysis based on the large-scale clinical database MIMIC-IV

Luo, Mengdi; Yang, Cheng-Fu; Cheng, Yuan; Li, Na; He, Qun

doi:10.1371/journal.pone.0265758

Cited by 30 publications

(21 citation statements)

References 24 publications

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“…Hemodilution can occur in patients who are edematous, hypervolemic, or who appear to be euvolemic on clinical examination [24]. A low hematocrit, especially when compounded with true anemia, results in higher mortality in patients with congestive heart failure [24] and sepsis [25]. In our case, a normal hematocrit level is associated with a protective factor of severe CAP.…”

Section: Discussionmentioning

confidence: 54%

“…Anemia has been found to increase children's susceptibility to contracting pneumonia [27] and increases the risk of death [18,28]. Although the biomolecular mechanism for a low hematocrit level contributing to increased death has yet to be fully elucidated, some theories exist [25]. Acute systemic infections cause inflammatory responses, which reduce the number of red blood cells entering circulation dramatically [29].…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with severe childhood community-acquired pneumonia: a retrospective study from two hospitals

Muljono

Halim

Heriyanto

et al. 2022

Egypt Pediatric Association Gaz

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Background Community-acquired pneumonia (CAP) is the leading cause of death in children globally. Indonesia is ranked 1st in South East Asia with the highest burden of pneumonia. Identification of risk factors is necessary for early intervention and better management. This study intended to describe CAP’s clinical signs and laboratory findings and explore the risk factors of severe CAP among children in Indonesia. Methods This was a retrospective study of childhood hospitalizations in Siloam General Hospitals and Siloam Hospitals Lippo Village from December 2015 to December 2019. Demographic data, clinical signs, and laboratory findings were collected and processed using IBM SPSS 26.0. Results This study included 217 participants with 66 (30.4%) severe pneumonia cases. Multivariate analysis shows that fever that lasts more than 7 days (ORadj = 4.95; 95%CI 1.61–15.21, Padj = 0.005) and increase in respiratory rate (ORadj = 1.05, 95%CI 1.01–1.08, Padj = 0.009) are two predictors of severe pneumonia. Meanwhile, a normal hematocrit level (ORadj = 0.9; 95%CI 0.83–0.98, Padj = 0.011) and children with normal BMI (ORadj = 0.7; 95%CI 0.57–0.84, Padj < 0.001) are significant independent predictors of severe pneumonia. The Hosmer-Lemeshow test shows that this model is a good fit with a P-value of 0.281. The AUC for this model is 0.819 (95%CI = 0.746–0.891, P-value < 0.001) which shows that this model has good discrimination. Conclusion Pediatric CAP hospitalizations with fever lasting > 7 days and tachypnea were at higher risk for progressing to severe pneumonia. A normal hematocrit level and a normal BMI are protective factors for severe pneumonia.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Factors associated with severe childhood community-acquired pneumonia: a retrospective study from two hospitals

Muljono

Halim

Heriyanto

et al. 2022

Egypt Pediatric Association Gaz

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“…Analyte-specific validation for Hct effect is particularly important because Hct levels can vary significantly among individuals and even within individuals at different times. 66 The accuracy and precision of glutathione and glutathione disulphide measurements using this approach were comparable to those of conventional liquid-blood analyses. However, technological advances are application-specific and must be validated to ensure comparable outcomes to conventional approaches.…”

Section: Sub-classificationmentioning

confidence: 73%

Blood microsampling technologies: Innovations and applications in 2022

Thangavelu

Wouters

Kindt

et al. 2023

Analytical Science Advances

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With the development of highly sensitive bioanalytical techniques, the volume of samples necessary for accurate analysis has reduced. Microsampling, the process of obtaining small amounts of blood, has thus gained popularity as it offers minimal‐invasiveness, reduced logistical costs and biohazard risks while simultaneously showing increased sample stability and a potential for the decentralization of the approach and at‐home self‐sampling. Although the benefits of microsampling have been recognised, its adoption in clinical practice has been slow. Several microsampling technologies and devices are currently available and employed in research studies for various biomedical applications. This review provides an overview of the state‐of‐the‐art in microsampling technology with a focus on the latest developments and advancements in the field of microsampling. Research published in the year 2022, including studies (i) developing strategies for the quantitation of analytes in microsamples and (ii) bridging and comparing the interchangeability between matrices and choice of technology for a given application, is reviewed to assess the advantages, challenges and limitations of the current state of microsampling. Successful implementation of microsampling in routine clinical care requires continued efforts for standardization and harmonization. Microsampling has been shown to facilitate data‐rich studies and a patient‐centric approach to healthcare and is foreseen to play a central role in the future digital revolution of healthcare through continuous monitoring to improve the quality of life.

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“…A recent research, however, discovered that fever alone did not consistently distinguish juvenile CAP from other respiratory infections [15,16]. A previous investigation reported that temperature of 39 °C was associated with pediatric pneumonia mortality at an adjusted risk ratio of 1.9 [17]. Furthermore, the length of illness, particularly fever, has been linked to a poor prognosis in children with pneumonia [18,19].…”

Section: Resultsmentioning

confidence: 98%

A Retrospective Study on Factors Associated with Severe Childhood Community-Acquired Pneumonia

Shahzad¹,

Rashid²,

Khan³

et al. 2023

PJMHS

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Background and Aim: Globally, community-acquired pneumonia (CAP) is the most common source of mortality among children. Early diagnosis and effective management need the identification of risk factors. The purpose of this study was to characterize the clinical symptoms and investigation of various risk factors for severe CAP in children. Patients and Methods: A retrospective study was conducted on 186 children in the Pediatric Department of Niazi Welfare Teaching Hospital, Sargodha from March 2022 to November 2022. Children with pneumonia who had radiological confirmation were included. Community-acquired pneumonia cases were categorized into two groups: Group-I composed of severe CAP cases whereas Group-II non-severe CAP cases. Baseline characteristics such as age, nutritional status, and gender were collected. Vital signs, fever, duration of symptoms, and physical findings such as chest retraction, cyanosis, wheezing, and nasal faring were clinical data recorded. Laboratory findings such as serum electrolyte, full blood count, and inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were recorded. SPSS version 27 was used for data analysis. Results: Of the total 186 children, there were 74 (39.8%) females and 112 (60.2%) male. Age-wise distribution of patients were as follows: 146 (78.5%) in 0-5 years, 26 (14%) in 6-10 years, and 14 (7.5%) in 11-15 years. Out of 186 children, the incidence of severe and non-severe CAP was 58 (31.2%) and 130 (68.8%) respectively. The most common clinical signs in both categories are fever and cough, followed by reduced appetite, vomiting, and shortness of breath. A seizure is present in 14 (24.1%) severe CAP cases. Based on physical examination, Rhonchi is found in 94 (72.3%) non-severe and 46 (79.3%) severe CAP patients. Among patients with severe pneumonia, over half have chest retractions, but only 22% have non-severe pneumonia. Tachypnea was experienced by approximately 33% of severe pneumonia patients against 14% of individuals with non-severe pneumonia. As inflammatory indicators, ESR and CRP are high in all groups. Conclusion: The present study concluded that a fever persisting for >7 days and an elevation in RR are risk factors for severe pneumonia. Severe pneumonia is also prevented by a normal hematocrit level and BMI. There was a higher rate of severe pneumonia in CAP hospitalizations in children who had fevers lasting longer than seven days as well as tachypnea. According to these findings, RR should be utilized to determine both the severity of pneumonia and the identification of pneumonia. Keywords: Sever community-acquired pneumonia, Risk factors, Childhood pneumonia

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Association between hematocrit and the 30-day mortality of patients with sepsis: A retrospective analysis based on the large-scale clinical database MIMIC-IV

Cited by 30 publications

References 24 publications

Factors associated with severe childhood community-acquired pneumonia: a retrospective study from two hospitals

Factors associated with severe childhood community-acquired pneumonia: a retrospective study from two hospitals

Blood microsampling technologies: Innovations and applications in 2022

A Retrospective Study on Factors Associated with Severe Childhood Community-Acquired Pneumonia

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