Association between hepatic lipase −514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference

Baylin, Ana; Ruiz-Narváez, Edward A.; Jensen, Majken K.; Rimm, Eric B.; Campos, Hannia

doi:10.1016/j.numecd.2009.05.006

Cited by 4 publications

(6 citation statements)

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“…9–11 These enzymes share sequence similarities (38%–44% identities) and are usually referred to as the vascular lipase gene family 7,12,13 because of their contributions to plasma lipoprotein, cholesterol, and triglyceride phenotypes and to the development of coronary heart diseases in human and animal populations. 14–21 …”

Section: Introductionmentioning

confidence: 99%

Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies

Holmes¹,

VandeBerg²,

Cox³

2011

OAB

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Hepatic lipase (gene: LIPC; enzyme: HL; E.C.3.1.1.3) is one of three members of the triglyceride lipase family that contributes to vascular lipoprotein degradation and serves a dual role in triglyceride hydrolysis and in facilitating receptor-mediated lipoprotein uptake into the liver. Amino acid sequences, protein structures, and gene locations for vertebrate LIPC (or Lipc for mouse and rat) genes and proteins were sourced from previous reports and vertebrate genome databases. Lipc was distinct from other neutral lipase genes (Lipg encoding endothelial lipase and Lpl encoding lipoprotein lipase [LPL]) and was located on mouse chromosome 9 with nine coding exons on the negative strand. Exon 9 of human LIPC and mouse and rat Lipc genes contained “stop codons” in different positions, causing changes in C-termini length. Vertebrate HL protein subunits shared 58%–97% sequence identities, including active, signal peptide, disulfide bond, and N-glycosylation sites, as well as proprotein convertase (“hinge”) and heparin binding regions. Predicted secondary and tertiary structures revealed similarities with the three-dimensional structure reported for horse and human pancreatic lipases. Potential sites for regulating LIPC gene expression included CpG islands near the 5″-untranslated regions of the mouse and rat LIPC genes. Phylogenetic analyses examined the relationships and potential evolutionary origins of the vertebrate LIPC gene family with other neutral triglyceride lipase gene families (LIPG and LPL). We conclude that the triglyceride lipase ancestral gene for vertebrate neutral lipase genes (LIPC, LIPG, and LPL) predated the appearance of fish during vertebrate evolution.

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Section: Introductionmentioning

confidence: 99%

Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies

Holmes¹,

VandeBerg²,

Cox³

2011

OAB

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“…Mean individual ancestry proportions in controls are 57.8% European, 38.3% Amerindian, and 3.8 West African (Ruiz-Narvaez et al 2010) (Figure 1). This study has generated numerous publications particularly on diet and lifestyle risk factors, as well as genetic markers for cardiovascular risk (Baylin et al, 2010; Baylin et al, 2007; Campos et al, 2008; Martinez-Ortiz et al, 2006). Admixture mapping has been used to find genes that underlie ethnic differences in disease risk among admixed populations (Mao et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In a study, Baylin et al (Baylin et al 2010) examined the association between the −514 C/T polymorphism of the hepatic lipase gene ( LIPC ) and nonfatal MI in total of 1940 pairs of cases and controls. The −514T variant was not associated with MI in the whole population.…”

Section: Introductionmentioning

confidence: 99%

Genetic Predictors for Cardiovascular Disease in Hispanics

Campos

2011

Trends in Cardiovascular Medicine

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A less favorable cardiovascular risk factor profile, but paradoxically lower cardiovascular morbidity and mortality have been observed in Hispanics, a pattern often referred to as the Hispanic Paradox. It was proposed the specific genetic susceptibility of this admixed population and gene-environment interactions may partly explain the paradox. The past few years have seen great advances in discovering genetic risk factors using genome-wide association studies (GWAS) for cardiovascular disease especially in Caucasians. However, there is no GWAS of cardiovascular disease that have been reported in Hispanics. In the Costa Rican Heart Study we reported both the consistency and disparity of genetic effects on risk of coronary heart disease (CHD) between Hispanics and other ethnic groups. We demonstrated the improvement in the identified genetic markers on discrimination of CHD in Hispanics was modest. Future genetic research in Hispanics would consider the diversities in genetic structure, lifestyle and socioeconomics among various sub-populations, and comprehensively evaluate potential gene-environment interactions in relation to cardiovascular risk.

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“…The C-514T SNP is associated with coronary artery disease, 17,18 nonalcoholic fatty liver, 27 and myocardial infarction. 16 Similarly, the G-250A polymorphism has been found to be associated with type 2 diabetes, 25,28 peripheral arterial disease, 14,15 and postprandial lipemic response. 29 The common link between these diseases and G-250A and C-514T polymorphisms could be because of their impact on HL activity.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13] Both C-514T and G-250A SNPs are associated with cardiovascular diseases (CVDs). [14][15][16][17][18] The distribution and clinical significance of LIPC C-514T and G-250A polymorphisms have been extensively investigated among the Europeans, Asians, and Americans, 12,13,15,17,[19][20][21][22][23][24][25] while they are still widely unknown among Arabs. Therefore, in this study, LIPC C-514T and G-250A polymorphisms and association with plasma lipid profile in young Jordanians were investigated.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Polymorphisms of Hepatic Lipase with Lipid Profile in Young Jordanian Adults

et al. 2014

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The human hepatic lipase (LIPC) gene encodes hepatic lipase, an enzyme involved in lipoprotein metabolism and regulation. Therefore, variants in LIPC gene may influence plasma lipoprotein levels. In this study, the association of LIPC C-514T and G-250A polymorphisms with plasma lipid profiles in 348 young Jordanians was investigated. Genotyping of C-514T and G-250A was performed by polymerase chain reaction and subsequent digestion with DraI and NiaIII restriction enzymes, respectively, while Roche analyzer was used to determine plasma total cholesterol, triglycerides, low-and high-density lipoprotein. The G-250 and C-514 alleles were most abundant in Jordanians with 79 and 80% frequencies, respectively. Additionally, no difference was found in the lipid–lipoprotein profile between the different genotype groups of C-514T or G-250A polymorphisms, even when males and females were examined separately (P > 0.05). In young Jordanian adults, the examined LIPC polymorphisms seem to play a limited role in determining the lipid profile.

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Association between hepatic lipase −514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference

Abstract: Background and aims-To examine whether the association between the -514C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist circumference.

Cited by 4 publications

References 37 publications

Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies

Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies

Genetic Predictors for Cardiovascular Disease in Hispanics

Lack of Association between Polymorphisms of Hepatic Lipase with Lipid Profile in Young Jordanian Adults

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