2014
DOI: 10.1111/apt.12670
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Association between high dietary intake of the n−3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease

Abstract: SummaryBackgroundThere are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).AimTo conduct a prospective study to investigate the association between increased intake of DHA and risk of CD.MethodsOverall, 229 702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitore… Show more

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Cited by 80 publications
(50 citation statements)
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References 37 publications
(68 reference statements)
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“…High intakes of linoleic acid, 6 animal proteins, 7 as well as low intakes of docosohexaenoic acid (DHA) have been associated with a higher risk of UC. High intakes of animal protein 7 as well as low intakes of fiber and fruit 8,9 and DHA 10 have been associated with a greater risk of CD.…”
Section: Text Introductionmentioning
confidence: 99%
“…High intakes of linoleic acid, 6 animal proteins, 7 as well as low intakes of docosohexaenoic acid (DHA) have been associated with a higher risk of UC. High intakes of animal protein 7 as well as low intakes of fiber and fruit 8,9 and DHA 10 have been associated with a greater risk of CD.…”
Section: Text Introductionmentioning
confidence: 99%
“…A multicenter European study of 229,702 participants was the first to look at the relationship between dietary intake of the PUFA, docosahexaenoic acid (DHA), and CD. A significant inverse relationship between the development of CD and dietary intake of DHA was found [11]. However the Nurses' Health Study I and II did not find any association with long-term intake of total fat, saturated fats, or unsaturated fats with risk for CD [12].…”
Section: Prospective Studiesmentioning
confidence: 90%
“…Findings from the European Investigation into Cancer and Nutrition (EPIC) Study and the Nurses' Health Study (NHS) are particularly noteworthy because of their large well-characterized cohorts [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. These studies have investigated the involvement of dietary factors such as dietary patterns, vitamin D, dietary fibre, zinc, dairy products, n-3 and n-6 polyunsaturated fatty acids (PUFA), and protein, 3 of 15 particularly animal protein, in IBD development [14,[16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The increases in IBD seen in developing countries as they adopt a Western lifestyle [5], and the high incidence among immigrants coming from low to high incidence areas, strongly suggest the involvement of other environmental factors such as lifestyle factors in disease aetiology [31].…”
Section: Environmental Factors In Ibdmentioning
confidence: 99%