Association between High <i>miR-211</i> microRNA Expression and the Poor Prognosis of Oral Carcinoma

Chang, Kuo Wei; Liu, C.-J.; Chu, Ting; Cheng, Hui; Hung, Pei Shih; Hu, Wen; Lin, Shu Chun

doi:10.1177/154405910808701116

Cited by 130 publications

(147 citation statements)

References 23 publications

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“…Furthermore, let7a overexpression results in the inhibition of lung cancer cell growth (19), as well as the growth of human colon cancer cells (20). recent studies have shown an association between mirna expression, such as let7 and mir-205, and the severity and poor survival in patients with head and neck cancer (21,22). Our data did not confirm a tumor-suppressor role for let7a in the pathogenesis of OScc.…”

Section: Discussioncontrasting

confidence: 53%

Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging

Gomez¹

2009

Exp Ther Med

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Abstract. micrornas (mirnas) mir15a and let7a are important regulators of bcl-2, ras and c-myc proteins. considering that these mirnas are commonly altered in many human cancers and that these proteins are reported to be altered in oral squamous cell carcinoma (OScc), we investigated them in a set of OScc cases. the mirnas as well as the proteins were evaluated in the tumor and blood of 20 patients by real-time quantitative pcr and immunohistochemistry, respectively. the expression of mir15a and bcl-2 proteins in the tumors was not associated with each other or with tumor staging. On the other hand, we found reduced expression of this mirna in the blood of patients with an advanced stage of OScc and with lymph node metastasis. the expression of let7a in the tumor and blood was not associated with tumor size, lymph node metastasis, tumor staging and immunoexpression of ras and c-myc proteins. in conclusion, the present study shows that reduced expression of mir15a is associated with OScc staging.

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Section: Discussioncontrasting

confidence: 53%

Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging

Gomez¹

2009

Exp Ther Med

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“…Links have been found between miRNAs and numerous developmental and pathological processes [13,15] . In particular, miR-204 and miR-211 belong to the same miRNA sub-family and share the same seed sequence: miR-204 is embedded in intron 6 of the TRPM3 gene (transient receptor potential melastatin 3) and has been shown to be a key regulator in metabolism, cell death, and cardiovascular disease [16][17][18][19][20] , and miR-211 is encoded by intron 6 of the TRPM1 gene [17,21] and also been shown to play important roles in cell survival and cancer [22][23][24] . miR-204 is completely conserved between human and mouse.…”

Section: Introductionmentioning

confidence: 99%

Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells

et al. 2015

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Aim:The mitochondrial targeted 2C-type serine/threonine protein phosphatase (PP2Cm) is encoded by the gene PPM1K and is highly conserved among vertebrates. PP2Cm plays a critical role in branched-chain amino acid catabolism and regulates cell survival. Its expression is dynamically regulated by the nutrient environment and pathological stresses. However, little is known about the molecular mechanism underlying the regulation of PPM1K gene expression. In this study, we aimed to reveal how PPM1K expression is affected by miRNA-mediated post-transcriptional regulation. Methods: Computational analysis based on conserved miRNA binding motifs was applied to predict the candidate miRNAs that potentially affect PPM1K expression. Dual-luciferase reporter assay was performed to verify the miRNAs' binding sites in the PPM1K gene and their influence on PPM1K 3'UTR activity. We further over-expressed the mimics of these miRNAs in human and mouse cells to examine whether miRNAs affected the mRNA level of PPM1K. Results: Computational analysis identified numerous miRNAs potentially targeting PPM1K. Luciferase reporter assays demonstrated that the 3'UTR of PPM1K gene contained the recognition sites of miR-204 and miR-211. Overexpression of these miRNAs in human and mouse cells diminished the 3'UTR activity and the endogenous mRNA level of PPM1K. However, the miR-22 binding site was found only in human and not mouse PPM1K 3'UTR. Accordingly, PPM1K 3'UTR activity was suppressed by miR-22 overexpression in human but not mouse cells. Conclusion: These data suggest that different miRNAs contribute to the regulation of PP2Cm expression in a species-specific manner. miR-204 and miR-211 are efficient in both mouse and human cells, while miR-22 regulates PP2Cm expression only in human cells.

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“…miR-211 is predicted to target multiple genes, including genes involved in angiogenesis and apoptosis. An association was found between higher miR-211 expression and advanced nodal metastasis, vascular invasion, and poor prognosis of oral carcinoma [61]. Enforced miR-211 expression significantly increased the proliferation, migration, and anchorage-independent colony formation of oral carcinoma cells [61].…”

Section: Mirna Profile Of Oral Squamous Cell Carcinomamentioning

confidence: 90%

“…An association was found between higher miR-211 expression and advanced nodal metastasis, vascular invasion, and poor prognosis of oral carcinoma [61]. Enforced miR-211 expression significantly increased the proliferation, migration, and anchorage-independent colony formation of oral carcinoma cells [61]. The mir-211 expression may be associated with the progression of oral carcinoma and poor patient outcomes [61].…”

Section: Mirna Profile Of Oral Squamous Cell Carcinomamentioning

confidence: 99%

Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature

Tonchev¹,

Vladimirov²,

Sarafian³

et al. 2017

Int J Surg Med

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Oral squamous cell carcinoma (OSCC) is the most common cancer type arising in the oral cavity and belongs to the wider group of head and neck cancers (HNCs).MicroRNAs (miRNAs) in mature form are noncoding RNAs, that regulate posttranscriptional gene expression by relatively nonspecific binding.As a result a single miRNA may regulate/control the expression of several genes which are involved in a variety of cellular processes like regulation of cellular differentiation, proliferation and apoptosis thus playing a role in cancer development.The AIM of this review was to summarize current findings on the effect of HPV status and presence of risk factors -smoking and alcohol consumption on miRNA expression as cancer biomarkers in patients with OSCC.

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Association between High miR-211 microRNA Expression and the Poor Prognosis of Oral Carcinoma

Cited by 130 publications

References 23 publications

Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging

Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging

Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells

Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature

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