Association between HLA-A1, B8 in children with extrinsic asthma and IgA deficiency

Østergaard, Poul Aabel; Eriksen, Jeppe

doi:10.1007/bf00444347

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…The same haplotype was also associated with asthmatic children with an IgA deficiency [24] and nasal polyposis [30]. An increased frequency of Bw6 among patients with nonallergic asthma was also reported, suggesting an association with a recessive inheritance model.…”

Section: Introductionmentioning

confidence: 85%

“…The human leukocyte antigen (HLA) system has been indicated as a genetic factor that may be associated with the disease. The first studies described in the literature that addressed the association between asthma and the HLA system were performed with HLA class I [23,24,25,26,27] and subsequently with HLA class II [28,29] genes. Different criteria were used to characterize the patients in the studied populations, and their asthma phenotypes were not well established.…”

Section: Introductionmentioning

confidence: 99%

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Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

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Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

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“…Molecular typing of the selected HLA classes I and II allelic groups was performed by polymerase chain reaction using sequence‐specific primers (PCR‐SSP). We studied the allelic groups which have been reported previously to be associated with childhood asthma in various populations . The primer sequences of HLA class I allelic groups were taken from Bunce et al and of class II allelic groups were obtained from Zhu et al and Sacchetti et al .…”

Section: Characteristics Of Asthmatic and Control Subjectsmentioning

confidence: 99%

A study of the association of childhood asthma with HLA alleles in the population of Siliguri, West Bengal, India

2014

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Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. It is a complex disorder influenced by gene-environment interaction. Human leukocyte antigen (HLA) genes have been shown to be consistently associated with asthma and its related phenotypes in various populations. The aim of this study was to determine the frequency of the selected HLA classes I and II allelic groups in asthmatic and control groups. HLA typing was performed using polymerase chain reaction-sequence-specific typing (PCR-SSP) method. The allele frequency was estimated by direct counting. Frequency of each HLA allelic group was compared between asthmatic group and control group using χ(2) test. P-value was corrected by multiplying with the number of the allelic groups studied. Odds ratio (OR) and its corresponding 95% confidence interval (CI) for each allelic group were calculated using graphpad instat 3.10. The results of this study showed a significantly higher frequency of HLA-DRB1*03 in asthmatics than in controls (11.43% vs 3.64%, OR = 3.78, 95% CI = 1.61-8.85, P = 0.0025, Pcorr < 0.05). Analysis of HLA alleles in low and high total serum immunoglobulin E (IgE) level in asthmatics revealed no significant association. HLA-DRB1*03 may be implicated in the susceptibility to asthma in the pediatric population.

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“…Initial MHC studies demonstrated an association between IgA-D and the class I alleles HLA-A1 -A2 and -B8 (2,3). Subsequent studies reported associations with several class I and I1 alleles, including HLA-A1, -A28, -B8, -B40, -DR3 and -DR7 (4)(5)(6).…”

mentioning

confidence: 99%