Association between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and cancer risk: A meta-analysis and systematic review

Ge, Yu‐Zheng; Ge, Qian; Li, Minghao; Shi, Guomei; Xu, Xiao; Xu, Luwei; Xu, Zheng; Lu, Tian-Ze; Wu, Rongqian; Zhou, Lin; Wu, Jianping; Liang, Ke; Dou, Qingyu; Zhu, Jun; Li, Wencheng; Jia, Ru

doi:10.1016/j.humimm.2014.06.004

Cited by 31 publications

(20 citation statements)

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“…Regarding Asian populations, a study published in 2014 found a significant association between the presence of the ins/ins genotype and breast cancer susceptibility in this demographic (Ge et al, 2014). HLA-G pathological expression is well correlated to HCC.…”

Section: Discussionmentioning

confidence: 97%

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

et al. 2016

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Section: Discussionmentioning

confidence: 97%

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

et al. 2016

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“…While the majority of these studies have reported increased levels of HLA-G in patients (Chen et al, 2010;Eskandari-Nasab et al, 2013;Jeong et al, 2014;Ramos et al, 2014;Zidi et al, 2016), a few studies, however, did not find differences between patients and controls (Palmisano et al, 2002). A recent meta-analysis revealed that the HLA-G 14-bp ins/del polymorphism may contribute to BC susceptibility and overall cancer risk in Asian populations (Ge et al, 2014). They reported a significant association between the ins allele and the homozygous ins/ins genotype and reduced risk of BC.…”

Section: Discussionmentioning

confidence: 99%

Research Article Association of HLA-G 14-base pair insertion/deletion polymorphism with breast cancer in Saudi Arabia

Alomar¹,

Mansour²

2019

Genet. Mol. Res.

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Human leukocyte antigen-G (HLA-G) has been associated with various immune diseases, including malignancies. The 14-base pair (bp) insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene has been reported to influence HLA-G protein expression. We investigated the relationship between the 14-bp indel polymorphism and the occurrence of breast cancer in a Saudi population. The HLA-G 14-bp polymorphism was typed by PCR in 52 patients with breast cancer and 62 healthy control Saudi women. There was a highly significant association between the occurrence of breast cancer and the del allele (OR = 3.75; P < 0.001) and the del/del genotype (OR = 4.96; P < 0.001). Conversely, the 14-bp ins allele and ins/ins genotype exhibited protective effects against breast cancer (P < 0.00001). Remarkably, the genotype 14-bp ins/ins was missing among all patients. This is the first report showing a strong association between HLA-G 14-bp polymorphism and breast cancer in the Saudi population. The results are in agreement with previous reports showing similar association of HLA-G and breast cancer in other populations.

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“…3A). HLA-G contains in its 39 UTR 14-bp insertion polymorphism that was shown to play a role in regulation of HLA-G expression (23,24). To test whether a 14-bp insertion/deletion plays a role in HNRNPR regulation, we expressed HLA-G with its 39 UTR that includes either the 14-bp insertion or deletion in 721.221 cells.…”

Section: Hnrnpr Positively Regulates Mhc Class I Protein Expressionmentioning

confidence: 99%

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins

Reches¹,

Nachmani²,

Berhani³

et al. 2016

The Journal of Immunology

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MHC class I molecules, in addition to their role in specific activation of the CTL of adaptive immune system, function also as the main ligands for NK cell inhibitory receptors, which prevent NK cells from killing normal, healthy cells. MHC class I proteins are divided into classical and nonclassical proteins. The former group consists of hundreds of HLA-A, B, and C alleles, which are universally expressed, whereas several alleles of the latter group, such as HLA-G, manifest a restricted expression pattern. Despite the important role played by these molecules in innate and adaptive immune responses, their complex expression regulation is not fully known. In our study, we investigated the regulation processes controlling the expression of MHC class I molecules, with a particular focus on their 3′ untranslated regions. We identified heterogeneous nuclear ribonucleoprotein R (HNRNPR) as an important positive regulator of classical and nonclassical MHC class I molecules. HNRNPR is a RNA-binding protein belonging to the heterogeneous nuclear ribonucleoprotein family, which has a known role in processing of precursor mRNA. We demonstrated that HNRNPR binds MHC class I mRNAs in their 3′ untranslated regions and enhances their stability and consequently their expression. Furthermore, regulation by HNRNPR modulates the cytotoxic activity of NK cells. In conclusion, we show that HNRNPR acts as a general positive regulator of MHC class I expression.

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Association between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and cancer risk: A meta-analysis and systematic review

Cited by 31 publications

References 36 publications

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

Research Article Association of HLA-G 14-base pair insertion/deletion polymorphism with breast cancer in Saudi Arabia

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins

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