Association between Human Leukocyte Antigens (HLA-A, -B, and -DR) and end-stage renal disease in Kuwaiti patients awaiting transplantation

Mosaad, Youssef M.; Mansour, Merveet A; Al-Muzairai, I.; Al-Otabi, Turky; Abdul-Moneam, Mohamed; Al‐Attiyah, Rajaa; Shahin, Manal

doi:10.3109/0886022x.2014.937672

Cited by 22 publications

(28 citation statements)

References 32 publications

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“…Several reports have examined possible associations between HLA types and ESRD 182,183,184 . Most of these studies have studied waitlisted candidates for renal transplantation in fairly homogeneous ethnic populations.…”

Section: Hla and Disease-independent Risk Of Esrdmentioning

confidence: 99%

HLA and kidney disease: from associations to mechanisms

et al. 2018

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Since the first association between HLA and diseases of native kidneys was described almost 50 years ago, technological and conceptual advances in HLA biology and typing, together with better case ascertainment, have led to an improved understanding of HLA associations with a variety of renal diseases. A substantial body of evidence now supports the existence of HLA genetic associations in the field of renal disease beyond the role of HLA in allogeneic responses in transplant recipients. Allomorphs of HLA have emerged as important risk factors in most immune-mediated renal diseases, which, together with other genetic and environmental factors, lead to loss of tolerance and autoimmune-mediated renal inflammation. HLA associations have also been described for renal diseases that are less traditionally seen as autoimmune or immune-mediated. Here, we review essential concepts in HLA biology and the association of HLA with diseases of the native kidneys, and describe the current understanding of the epistatic and mechanistic bases of HLA-associated kidney disease. Greater understanding of the relationship between HLA and kidney function has the potential not only to further the understanding of immune renal disease at a fundamental level but also to lead to the development and application of more effective, specific and less toxic therapies for kidney diseases.

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Section: Hla and Disease-independent Risk Of Esrdmentioning

confidence: 99%

HLA and kidney disease: from associations to mechanisms

et al. 2018

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“…Few of these disorders are immune-mediated, while, in others, the pathogenesis is unclear or the relevance of HLA is not entirely understood. The end-stage renal disease (ESRD)-last stage of chronic renal failure-has become a global health problem [2] and has been investigated for HLA association [3][4][5]. In the majority of the previous works, ESRD patients waiting for kidney transplantation were examined.…”

Section: Introductionmentioning

confidence: 99%

Revisiting the association between human leukocyte antigen and end-stage renal disease

et al. 2020

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Multiple works have studied possible associations between human leukocyte antigen (HLA) alleles and end stage renal disease (ESRD) showing, however, contradictory and inconsistent results. Here, we revisit the association between ESRD and HLA antigens, comparing HLA polymorphism (at HLA-A,-B,-C,-DRB1,-DQB1 and DQA1 loci) in ESRD patients (n = 497) and controls (n = 672). Our data identified several HLA alleles that displayed a significant positive or negative association with ESRD. We also determined whether heterozygosity or homozygosity of the ESRD-associated HLA alleles at different loci could modify the prevalence of the disease. Few HLA allele combinations displayed significant associations with ESRD, among which A*3_26 combination showed the highest strength of association (OR = 4.488, P� 0.05) with ESRD. Interestingly, the age of ESRD onset was not affected by HLA allele combinations at different loci. We also performed an extensive literature analysis to determine whether the association of HLA to ESRD can be similar across different ethnic groups. Our analysis showed that at least certain HLA alleles, HLA-A*11, HLA-DRB1*11, and HLA-DRB1*4, display a significant association with ESRD in different ethnic groups. The findings of our study will help in determining possible protective or susceptible roles of various HLA alleles in ESRD.

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“…The role of the HLA system in the pathophysiology of ESRD is intriguing, but not completely resolved. Numerous associations and non-associations of HLA with ESRD have been reported in the medical literature, but with controversial results in Table 1 [82][83][84][85][86][87][88][89][90][91][92][93].…”

Section: Hla and End-stage Renal Diseasementioning

confidence: 99%

Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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Most of the genes in the major histocompatibility complex (MHC) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well -too well, in fact. Population studies carried out over the last several decades have identified a long list of human diseases that are significantly more common among individuals that carry particular HLA alleles including inflammatory, autoimmune and malignant disorders. HLAdisease association is the name of this phenomenon, and the mechanism underlying is still a subject of hot debate. Social behaviours are affected by HLA genes and preference for HLA disparate mates may provide 'good genes' for an individual's offspring. Also, certain HLA genes may be associated with shorter life and others with longer lifespan, but the effects depend both on the genetic background and on the environmental conditions. The following is a general overview of the important functional aspects of HLA in health and diseases.

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Association between Human Leukocyte Antigens (HLA-A, -B, and -DR) and end-stage renal disease in Kuwaiti patients awaiting transplantation

Cited by 22 publications

References 32 publications

HLA and kidney disease: from associations to mechanisms

HLA and kidney disease: from associations to mechanisms

Revisiting the association between human leukocyte antigen and end-stage renal disease

Clinical Role of Human Leukocyte Antigen in Health and Disease

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