Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study

Shimizu, Yūji; Yamanashi, Hirotomo; Kitamura, Masayasu; Furugen, Reiko; Iwasaki, Takahiro; Fukuda, Hideki; Hayashida, Hideaki; Kawasaki, Koji; Kiyoura, Kairi; Kawashiri, Shin‐ya; Kawakami, Atsushi; Maeda, Takahiro

doi:10.1186/s12199-019-0836-2

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…Finally, a total of 57 articles (Moya et al, 2012; Figueiredo et al, 2013; Araya Vallespir et al, 2014; Jaafar et al, 2014; Juarez et al, 2014; Thanakun et al, 2014; Bhat et al, 2015; Eke et al, 2015; Giacaman et al, 2016; Khan et al, 2016; Holde et al, 2017; Ramírez et al, 2017; Shyagali et al, 2017; Silva‐Junior et al, 2017; Zaitsu et al, 2017; Balaji et al, 2018; Bhat et al, 2018; Eke et al, 2018; He et al, 2018; Iwasaki et al, 2018; Ortiz et al, 2018; Pinto‐Filho et al, 2018; Shariff et al, 2018; Skośkiewicz‐Malinowska et al, 2018; Wahlin et al, 2018; Botelho et al, 2019; Dhaifullah et al, 2019; Helmi et al, 2019; Lasta et al, 2019; J. B. Lee et al, 2019; K. Lee & Kim, 2019; Shimizu et al, 2019; Zhao et al, 2019; Bongo et al, 2020; Díaz‐Reissner et al, 2020; Ha et al, 2020; Nakamura et al, 2020; Romero‐Castro et al, 2020; Schmidt et al, 2020; Sekiguchi et al, 2020; Singh et al, 2020; Sun et al, 2020; Bilgin Çetin et al, 2021; Clauss et al, 2021; Costa et al, 2021; Germen et al, 2021; Ghassib et al, 2021; Goel et al, 2021; Gomes‐Filho et al, 2021; Han & Kim, 2021; Iwasaki et al, 2021; Jiao et al, 2021; Kocher et al, 2021; Oliveira et al, 2021; Sakurai et al, 2021; Song et al,…”

Section: Resultsmentioning

confidence: 99%

Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta‐analysis of epidemiological studies

Trindade

Carvalho

Machado

et al. 2023

J Clinic Periodontology

130

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Aim The aim of the study was to evaluate the prevalence of periodontitis in dentate people between 2011 and 2020. Materials and Methods PUBMED, Web of Science, and LILACS were searched up to and including December 2021. Epidemiological studies reporting the prevalence of periodontitis conducted between 2011 and 2020 were eligible for inclusion in this review. Studies were grouped according to the case definition of confidence as confident (Centers for Disease Control [CDC] AAP 2012; CDC/AAP 2007; and Armitage 1999) and non‐confident (community periodontal index of 3 or 4, periodontal pocket depth >4 mm, and clinical attachment level ≥1 mm). Random effects meta‐analyses with double arcsine transformation were conducted. Sensitivity subgroup and meta‐regression analyses explored the effect of confounding variables on the overall estimates. Results A total 55 studies were included. The results showed a significant difference, with confident case definitions (61.6%) reporting nearly twice the prevalence as non‐confident classifications (38.5%). Estimates using confident periodontal case definitions showed a pooled prevalence of periodontitis of 61.6%, comprising 17 different countries. Estimates reporting using the CDC/AAP 2012 case definition presented the highest estimate (68.1%) and the CDC/AAP 2007 presented the lowest (48.8%). Age was a relevant confounding variable, as older participants (≥65 years) had the highest pooled estimate (79.3%). Conclusion Between 2011 and 2020, periodontitis in dentate adults was estimated to be around 62% and severe periodontitis 23.6%. These results show an unusually high prevalence of periodontitis compared to the previous estimates from 1990 to 2010.

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Section: Resultsmentioning

confidence: 99%

Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta‐analysis of epidemiological studies

Trindade

Carvalho

Machado

et al. 2023

J Clinic Periodontology

130

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“…This is the first study to report that an angiogenesis-related genetic factor could influence the infectious capacity of HTLV-1. Asymptomatic HTLV-1 infection is positively associated with periodontitis [ 22 , 23 ]. Because disruption of the microcirculation is the main pathology in periodontitis [ 24 ], HTLV-1 infection could be associated with disruption of the microcirculation.…”

Section: Discussionmentioning

confidence: 99%

VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

et al. 2022

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Previous studies have reported a close correlation between vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, and human T-cell leukemia virus 1 (HTLV-1). However, an association between genetic characteristics related to VEGF and HTLV-1 infection has not yet been reported. Because the VEGF polymorphism rs3025039 is inversely associated with serum concentrations of VEGF, we focus on rs3025039 in the present study. To clarify the association between the VEGF polymorphism rs3025039 and HTLV-1 infection, a cross-sectional study of 1924 Japanese individuals aged 60–79 years who participated in general health check-ups was conducted. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) for HTLV-1 infection in relation to rs3025039 genotype were calculated with adjustment for known confounders. Compared with rs3025039 CC-homozygotes, (T) allele carriers had a significantly lower OR for HTLV-1 infection. The adjusted OR and 95% CI for HTLV-1 infection was 0.70 (0.54–0.91) (p = 0.009). Genetic characteristics related to lower angiogenesis activity might be associated with a lower chance of establishing HTLV-1 infection. Although further investigation is necessary, angiogenesis might play a crucial role in the establishment of HTLV-1 infection.

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“…The HTLV virus was discovered in the early 1980s in the United States and Japan. The first studies evaluated the profile of patients, the transmissibility pathways and the affinity of HTLV with host cells (Nishijima et al, 2019;Rosadas, 2019;Shimizu et al, 2019).…”

Section: Previous Investigationmentioning

confidence: 99%

“…transport, cell migration and diffusion of antibodies that are extremely important for fighting microorganisms, neutralizing bacterial adherence and inactivating toxins. (Nishijima et al, 2019;Shimizu et al, 2019). g) Although the majority of HTLV-1 seropositive individuals are asymptomatic, HTLV-1 infection aggravates chronic periodontitis associated with the virus, whether symptomatic or asymptomatic patients.…”

Section: Pathogenesismentioning

confidence: 99%

The Relevance of Situational Strategic Planning and Combat Human T-Cell Lymphotropic Virus Associated With Periodontal Disorders

Ferreira,

Torres

2023

JHS

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This literature review evaluates the relationship between periodontal disease (PD) and human T-cell lymphotropic virus type 1 (HTLV-1) and whether this interaction occurs in symptomatic and asymptomatic patients.We investigated whether periodontal problems are triggered by the exacerbated immune response caused by HTLV-1 infection or by complex treatments related to the clinical manifestations of this deltaretrovirus. Currently, worldwide, HTLV-1 affects 20 million people, a number that may be underreported. Brazil occupies 1st place in the world ranking, apparently, with 2.5 million patients. Late diagnosis and the lack of effective treatment generate systemic changes, but also oral changes that contribute to the development and/or worsening of periodontal disease, which is why dentists must be prepared to face a probable hyperendemia. Recent studies have shown that many professionals are unaware of the existence of the virus. Addressing the issue must adopt a situational strategic planning proposal instead of deterministic planning models, which are more concerned with the economic aspect than with identifying and attacking the problems and threats of social reality, a mistaken trend in public management that, however, is still adopted and has generated social setbacks for Public Health.

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Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study

Cited by 5 publications

References 41 publications

Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta‐analysis of epidemiological studies

Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta‐analysis of epidemiological studies

VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

The Relevance of Situational Strategic Planning and Combat Human T-Cell Lymphotropic Virus Associated With Periodontal Disorders

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