Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis

Abstract

Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.

Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis

“…Patients with VL often have hypergammaglobulinemia and pancytopenia, with hypocholesterolemia and elevated triglycerides at the peak of symptomatic disease [8]. Plasma lipoproteins are coordinately regulated, with high VLDL (very low-density lipoprotein) and low levels of LDL (low-density lipoprotein), HDL and Apolipoprotein A1, compared with control subjects without VL [9].…”

Uso Do Plasma Rico Em Plaquetas Em Tratamentos Ortopédicos

“…Leishmaniasis is caused by an obligate intracellular parasite of the genus Leishmania that harbors several species responsible for different clinical forms(Hilaire et al 2022).Leishmania species are unicellular eukaryotes having a well-defined nucleus and other cell organelles including kinetoplasts and flagela(Ilıkçı Sağkan et al 2022). The most serious clinical form is the visceral, characterized by the reproduction of parasites inside the cells of the mononuclear phagocyte system, affecting the liver and causing morphofunctional changes with consequences for the functioning of the whole organism(Kaufer et al 2017, Moriconi M. et al 2017, Varela et al 2021. Some species of Leishmania are resistant to currently used chemotherapy drugs, making treatment difficult, contributing to leishmaniasis as the third-most lethal neglected disease, despite prevention and control efforts set by the Board of Directors of the Pan American Health Organization.…”

Gestão Da Inteligência Emocional No Processo De Formação Universitária Dos Estudantes De Fisioterapia

“…Leishmaniasis is caused by an obligate intracellular parasite of the genus Leishmania that harbors several species responsible for different clinical forms(Hilaire et al 2022).Leishmania species are unicellular eukaryotes having a well-defined nucleus and other cell organelles including kinetoplasts and flagela(Ilıkçı Sağkan et al 2022). The most serious clinical form is the visceral, characterized by the reproduction of parasites inside the cells of the mononuclear phagocyte system, affecting the liver and causing morphofunctional changes with consequences for the functioning of the whole organism(Kaufer et al 2017, Moriconi M. et al 2017, Varela et al 2021. Some species of Leishmania are resistant to currently used chemotherapy drugs, making treatment difficult, contributing to leishmaniasis as the third-most lethal neglected disease, despite prevention and control efforts set by the Board of Directors of the Pan American Health Organization.…”