Association Between Hypoglycemia and Fall-Related Events in Type 2 Diabetes Mellitus: Analysis of a U.S. Commercial Database

Kachroo, Sumesh; Kawabata, Hugh; Colilla, Susan; Shi, Lizheng; Zhao, Yingnan; Mukherjee, Jayanti; Iloeje, Uchenna H.; Fonseca, Vivian

doi:10.18553/jmcp.2015.21.3.243

Cited by 52 publications

(53 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The multiple and well-recognized complications of long-standing diabetes mellitus include peripheral neuropathy, diabetic retinopathy, autonomic neuropathy, and hypoglycemia from inappropriate glycemic control, all of which can significantly contribute to the risks of falls through multiple mechanisms (Morley, 1999). Recently, Kachoo et al (2015) showed that the risk of fall-related events increased 2-fold among elderly diabetic patients who experienced hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with falls in elderly patients with type 2 diabetes

Chiba

Kimbara

Kodera

et al. 2015

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Risk factors associated with falls in elderly patients with type 2 diabetes

Chiba

Kimbara

Kodera

et al. 2015

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

“…DM promotes peripheral nerve dysfunction and is a frequent cause of falls (29), although vitamin D 3 treatment reportedly plays a role in preventing falls (22). Thus, we hypothesized that Schwann cells were critical targets of DM and that vitamin D 3 might regulate their activity.…”

Section: High Glucose Concentrations Induce Schwann Cellmentioning

confidence: 97%

Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation

Tashiro

Hasegawa

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Factors that govern peripheral neuropathy associated with Schwann cell dysfunction are not fully understood. Results: Under hyperglycemic conditions, Schwann cells de-differentiate into immature cells via sorbitol accumulation and Igf1 down-regulation. Conclusion: Schwann cell de-differentiation promotes neuropathy development under hyperglycemic conditions. Significance: These findings reveal new mechanisms underlying neuropathy seen in diabetes mellitus via Schwann cell de-differentiation leading to de-myelination.

show abstract

“…Hypoglycaemia is one of the main complications of diabetes treatment and is associated with serious adverse events (12). The majority of studies exploring the association between hypoglycaemic events and fracture risk have used commercial health claims databases (13,14,15) or national hospital and psychiatric registers (16). The latter patients constitute a distinct subset and these findings may not be applicable to the general diabetic population.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study

Ntouva

Toulis

Keerthy

et al. 2019

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Type 2 diabetes is associated with an increased risk of fracture. Any factor that incrementally increases this risk should be taken into account when individualising treatment. Hypoglycaemia is a common complication of antidiabetes medications and suggested as a risk factor for fractures; yet, its real-life clinical impact is unclear. Design: A population-based, retrospective open cohort study using routinely collected data between 1st of January 1995 and 1st of May 2016 in The Health Improvement Network (THIN) database. Methods: Patients with type 2 diabetes mellitus with documented hypoglycaemic events were compared to randomly matched patients with type 2 diabetes mellitus without documented hypoglycaemic events matched to exposed patients on age, sex, duration of diabetes and BMI. The primary outcome was any incident fracture. Secondary outcome was incident fragility (osteoporotic) fracture. Results: A total of 41 163 patients with type 2 diabetes were included: 14 147 patients in the exposed cohort and 27 016 patients in the unexposed cohort. Patients with a documented hypoglycaemic event were significantly more likely to sustain any fracture compared to patients with no record of hypoglycaemic events: adjusted IRR = 1.20 (95% CI: 1.12-1.30; P < 0.0001). Patients who had a documented hypoglycaemic event were significantly more likely to suffer a fragility fracture compared to controls: adjusted IRR = 1.24 (95% CI: 1.13-1.37; P < 0.0001). Conclusions: Hypoglycaemic events are a significant risk factor for fractures in patients with diabetes mellitus. This observation is clinically relevant when individualising targets for glycaemic control and selecting antidiabetic agents. Clinical Study

show abstract

Association Between Hypoglycemia and Fall-Related Events in Type 2 Diabetes Mellitus: Analysis of a U.S. Commercial Database

Cited by 52 publications

References 36 publications

Risk factors associated with falls in elderly patients with type 2 diabetes

Risk factors associated with falls in elderly patients with type 2 diabetes

Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation

Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study

Contact Info

Product

Resources

About