Association between APOE polymorphisms and lipid profile in Mexican Amerindian population

Abstract

BackgroundApolipoprotein E (ApoE) is a glycoprotein that plays an important role in lipid homeostasis at both cerebral and systemic levels. Moreover, the differential distribution of APOE gene alleles among different populations, means that ApoE isoforms could have different effects on lipids metabolism. The present study aims to evaluate the relationship between APOE gene alleles and the lipid profile in a Mexican Amerindian (MA) population.MethodsThis study included 1997 MA individuals of different ethnicities distributed throughout different states of Mexico. All individuals underwent anthropometric measurements as well as laboratory tests including fasting glucose (FG), total cholesterol (TC), triglycerides, low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C). TaqMan® probe genotyping assays were used to genotype APOE. The Kruskal–Wallis test was performed to determine the correlation between APOE gene alleles and genotypes and the biochemical variables measured.ResultsAmong the biochemical variables analyzed, only the HDL‐C and LDL‐C levels showed statistical differences (p‐value < .05) between individuals carrying different APOE alleles. For HDL‐C, individuals carrying the E2 allele had higher HDL‐C levels, followed by individuals carrying the E3 allele and carriers of the E4 allele presented the lowest levels of HDL‐C (E2 > E3 > E4). This relationship was inversed for LDL‐C levels (E2 < E3 < E4). Nevertheless, the difference of HDL‐C levels between APOE‐E3 and APOE‐E4 carriers remained only in obese individuals.ConclusionsOur results suggest that APOE gene genotypes play an important role in the differential modulation of lipid profiles in the MA population with obesity.

Association of APOE E2 and low-density lipoprotein with depressive symptoms in Chinese senile schizophrenia inpatients: A cross-sectional study

“…The mechanism may be that APOE E2 can bind to low-density lipoprotein receptor (LDLR) by cysteine at amino acid position 158, which will affect the up-regulation of the synthesis of LDLR and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), resulting in low serum LDL levels ( Lee et al, 2011 ). Previous studies showed that APOE E4 was associated with higher LDL levels ( Martínez-Magaña et al, 2019 ; Wang et al, 2019 ); however, in the present study, we did not find such a relationship.…”

Determination of Apoe Gene Expression in Multiple Sclerosis Patients

“…Our results are in agreement with the findings reported by several studies indicating decreased plasma and APOE gene expression in MS patients (11,12). It is reported that some studies indicated a positive association between ApoE gene polymorphism and the risk of MS progression whereas other studies generated negative results (5,(13)(14)(15)(16)(17). However, the results remain controversial.…”

“…It is reported that some studies indicated a positive association between ApoE gene polymorphism and the risk of MS progression whereas other studies generated negative results (5,(13)(14)(15)(16)(17). However, the results remain controversial.…”

“…The apolipoprotein E (ApoE) gene localized on the chromosome 19q13 region is found in three common allelic forms: the APOE gene (Apo e2, e3, e4). The frequency of the ε4 allele is approximately 10-23 % in the general population (4)(5)(6). Research on APOE polymorphisms has found Apo E genotype being involved in other neurodegenerative diseases and ApoE-ε4 allele carriers seem to have a worse prognosis (7).…”

APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population

“…Variations in other lipid metabolism‐related genes based on population genetic differences may influence differences in lipid spectrum regulation 29‐31 . In addition, one factor that may modulate the relationship between APOE gene variations and lipid levels is body mass index (BMI) 32 . BMI information was not collected and analyzed, which was one of the shortcomings of this study.…”